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个人简介

侯桂革,男,博士,副教授,硕士生导师,药学院副院长,药物化学教研室负责 人。烟台市药学会理事。主要从事医用抗菌材料的研究与开发、药物合成与活性 评价等研究工作。目前,主持烟台市重点研发项目 1 项,主持并完成国家自然科 学基金项目 1 项,参与省部级课题 5 项。受邀 Eur J Med Chem、Chem Biol Drug Des、Mini-Rev Med Chem 等杂志审稿人。研究成果在 Chemcomm、Chem Eur J、 Eur J Med Chem、Int J Biolog Macromol、Chem Biol Drug Des、Acta Crystal C、 CrystEngComm 等国际权威期刊发表 SCI 论文 40 余篇,影响因子之和超过 80 分。 申请国家发明专利 15 项,其中授权 7 项。研究成果获烟台市科技进步奖三等奖 1 项和高等学校科研成果奖三等奖 2 项。 学习经历: 2008 年 9 月至 2011 年 6 月,山东师范大学,物理化学专业,博士研究生 2005 年 9 月至 2008 年 6 月,山东师范大学,有机化学专业,硕士研究生 2001 年 9 月至 2005 年 6 月,山东师范大学,化学专业,本科 工作经历: 2013 年 12 月至今,药学院,药物化学教研室,副教授 2011 年 7 月至 2013 年 12 月,药学院,药物化学教研室,讲师

研究领域

1. 医用抗菌材料的研究与开发 2. 药物合成与活性评价

近期论文

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(1) Ning Li, Wen-Yu Xin, Bin-Rong Yao, Chun-Hua Wang, Wei Cong, Feng Zhao, Hong-Juan Li, Yun Hou, Qing-Guo Meng* , Gui-Ge Hou* . Novel asymmetric 3,5-bis(arylidene)-4-piperidones as potential antitumor agents with biological evaluation in vitro and in vivo. European Journal of Medicinal Chemistry, 2018, 147, 21-33. (SCI 收录,影响因子 4.816) (2) Ning Li, Wen-Yu Xin, Bin-Rong Yao, Wei Cong, Chun-Hua Wang*, Gui-Ge Hou* . N-phenylsulfonyl-3,5-bis(arylidene)-4-piperidone derivatives as activation NF-kB inhibitors in hepatic carcinoma cell lines. European Journal of Medicinal Chemistry, 2018, 155, 531-544. (SCI 收录,影响因子 4.816) (3) Binrong Yao, Ning Li, Chunhua Wang,* Guige Hou,* Qingguo Meng and Ke Yan. Novel asymmetric 3,5-bis(arylidene)piperidin-4-one derivatives: synthesis, crystal structures and cytotoxicity. Acta Cryst. 2018. C74, 659–665. (SCI 收录,影响因子 8.678) (4) Ning Li, Binrong Yao, Chunhua Wang, Qingguo Meng and Guige Hou*. Synthesis, crystal structure and activity evaluation of novel 3,4-dihydro-1-benzoxepin-5(2H)-one derivatives as protein–tyrosine kinase (PTK) inhibitors. Acta Cryst. 2017. C73, 1003–1009. (SCI 收录,影响因子 8.678) (5) Xianrui Xie, Wei Cong, Feng Zhao, Hongjuan Li, Wenyu Xin, Chunhua Wang* , Gui-Ge Hou* , Synthesis, physiochemical property and antimicrobial activity of novel quaternary ammonium salts. J Enzyme Inhib Med Chem. 2017, 33(1):98-105. (SCI 收 录,影响因子 3.638) (6) Chun-Hua Wang* , Xian-Rui Xie, Wen-Shuai Liu, Gui-Ge Hou* , Ju-Feng Sun, Feng Zhao, Wei Cong, Hong-Juan Li, Wen-Yu Xin, Quaternary ammonium salts substituted by 5-phenyl-1,3,4-oxadiazole-2-thiol as novel antibacterial agents with low cytotoxicity. Chemical Biology & Drug Design, 2017, 90(5), 943-952. (SCI 收 录,影响因子 2.328) (7) Chun-Hua Wang* , Wen-Shuai Liu, Ju-Feng Sun, Gui-Ge Hou* , Qin Chen, Wei Cong, Feng Zhao, Non-toxic O-quaternized chitosan materials with better water solubility and antimicrobial function, International Journal of Biological Macromolecules, 2016, 84, 418-427. (SCI 收录,影响因子 3.671) (8) Qin Chen, Yun Hou, Gui-Ge Hou* , Ning Li, Wei Cong, Feng Zhao, Hong-Juan Li, Chun-Hua Wang, Ju-Feng Sun Synthesis, anticancer activity and cytotoxicity of novel double Schiff-base condensed α,β-unsaturated keto derivatives. Journal of Chemical Research, 2016, 40(7): 400-403. (SCI 收录,影响因子 0.668) (9) Qin Chen, Yun Hou, Gui-Ge Hou* , Ju-Feng Sun, Ning Li, Wei Cong, Feng Zhao, Hong Juan Li, Chun-Hua Wang* . Design, synthesis, anticancer activity and cytotoxicity of novel 4-piperidone/cyclohexanone derivatives. Research on Chemical Intermediates, 2016, 42(12): 8119-8130. (SCI 收录,影响因子 1.369) (10) Wen-Shuai Liu# , Chun-Hua Wang#* , Ju-Feng Sun, Gui-Ge Hou* , Yu-Peng Wang, Rong-Jun Qu. Synthesis, characterization and antibacterial properties of dihydroxy quaternary ammonium salts with long chain alkyl bromides. Chemical Biology & Drug Design, 2015, 85(1), 91–97. (SCI 收录,影响因子 2.802) (11) Hong-Juan Li, Lei Wang, Juan-Juan Zhao, Ju-Feng Sun, Ji-Liang Sun, Chun-Hua Wang, Gui-Ge Hou* . Synthesis, structure and luminescence of novel co-crystals based on bispyridyl-substituted α,β-unsaturated ketones with conformers. J Mol Struct, 2015, 1079, 414-422. (SCI 收录,影响因子 2.011) (12) Ju-Feng Sun* , Shu-Ping Zhang, Chen Yu, Gui-Ge Hou* , Xiao-Fan Zhang, Ke-Ke Li, Feng Zhao. Design, Synthesis and bioevaluation of novel N-substituted-3,5-bis(arylidene)-4-piperidone derivatives as cytotoxic and antitumor agents with fluorescent properties. Chem. Biol. Drug. Des. 2014, 83, 392-400. (SCI收 录,影响因子 2.802) (13) Xian-Ping Dai, Gui-Ge Hou* , Ju-Feng Sun, Dong Lin, Jing-Tian Han* . Synthesis, structure and luminescence of novel 2D co-crystals based on asymmetric 5-substituted pyrimidines and isophthalic acid: Alternate arrangement and π-π interactions. J Mol Struct, 2013, 1035, 203-208. (SCI 收录,影响因子 2.011) (14) Gui-Ge Hou* , Hui-Juan Zhao, Ju-Feng Sun, Dong Lin, Xian-Ping Dai, Jing-Tian Han, Hui Zhao. Synthesis, Structure and Luminescence of Co-crystals with Hexagonal Channels: Arranging Disposition and π-π Interactions. CrystEngComm, 2013, 15, 577-585. (SCI 收录,影响因子 3.849) (15) Gui-Ge Hou* , Chun-Hua Wang, Ju-Feng Sun, Mei-Zi Yang, Dong Lin, Hong-Juan Li. Rhodamine-based “turn-on” fluorescent probe with high selectivity for Fe2+ imaging in living cells. Biochem Biophys Res Co. 2013, 439, 459-463. (SCI 收 录,影响因子 2.559) (16) Gui-Ge Hou* , Ju-Feng Sun, Chun-Hua Wang* , Feng Zhao, Xian-Ping Dai, Hong-Juan Li, Jing-Tian Han. Synthesis, structural characterization and luminescence studies of three novel complexes of asymmetric 5-(1-imidazolyl)pyrimidine ligand. J Mol Struct, 2013, 1048, 295-300. (SCI 收录,影响因子 2.011) (17) Gui-Ge Hou, Yue Liu, Qi-Kui Liu, Jian-Ping Ma and Yu-Bin Dong* . NbO lattice MOFs based on octahedral M(II) and ditopic pyridyl substituted diketonate ligands: structure, encapsulation and guest-driven luminescent property. Chemcomm. 2011, 47, 10731-10733. (SCI 收录,影响因子 6.29)

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