王春华 - 滨州医学院

个人简介

王春华，女，中共党员，教授，硕士生导师，药学院院长。全国卫生产业企业管理协会抗菌产业分会专家委员会委员，山东医药生物技术协会常务理事，“方剂效应与临床评价”国家中医药管理局重点研究室主任，“中药现代化与新剂型开发”山东省中医药科研重点实验室主任，荣获山东省第三届“新世纪巾帼发明家” 称号。《药学教育》期刊特邀编委。主要从事医用抗菌材料的研究与开发、药物合成与活性评价、天然药物活性成分筛选与评价等研究工作。目前，主持山东省本科高校教学改革研究面上项目 1 项，主持并完成山东省自主创新及成果转化专项 1 项，山东省重点研发计划项目 1 项、山东省自然科学基金项目面上项目 1 项和烟台市科技发展计划项目 1 项，主持烟台市重点研发计划 1 项。相关研究成果在 Org Lett、Eur J Med Chem、Int J Biolog Macromol、Chem Biol Drug Des、 Acta Crystal C、Polymer Journal和Biochem Bioph Res Co等国际权威期刊发表SCI 论文 30 余篇。申请专利 15 项，其中授权 9 项。研究成果首位获得山东省科技进步奖三等奖 2 项、山东省高等学校优秀科研成果奖（自然科学类）三等奖 2 项和烟台市科技进步奖三等奖 1 项。学习经历： 2004 年 9 月至 2007 年 6 月，山东大学，有机合成专业，理学硕士研究生 1988 年 9 月至 1989 年 7 月，北京师范大学化学系有机化学助教进修班学习 1982 年 9 月至 1986 年 6 月，山东师范大学，化学专业，本科工作经历： 2012 年 7 月至今，药学院，教授 1986 年 7 月至 2012 年 7 月，鲁东大学，化学与材料科学学院，教授

研究领域

1. 医用抗菌材料的研究与开发 2. 药物合成与活性评价 3. 天然药物活性成分筛选与评价

近期论文

查看导师最新文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

(1) Ning Li, Wen-Yu Xin, Bin-Rong Yao, Wei Cong, Chun-Hua Wang*, Gui-Ge Hou* . N-phenylsulfonyl-3,5-bis(arylidene)-4-piperidone derivatives as activation NF-kB inhibitors in hepatic carcinoma cell lines. European Journal of Medicinal Chemistry, 2018, 155, 531-544. (SCI 收录，影响因子 4.816) (2) Ning Li, Wen-Yu Xin, Bin-Rong Yao, Chun-Hua Wang, Wei Cong, Feng Zhao, Hong-Juan Li, Yun Hou, Qing-Guo Meng* , Gui-Ge Hou* . Novel asymmetric 3,5-bis(arylidene)-4-piperidones as potential antitumor agents with biological evaluation in vitro and in vivo. European Journal of Medicinal Chemistry, 2018, 147, 21-33. (SCI 收录，影响因子 4.816) (3) Binrong Yao, Ning Li, Chunhua Wang,* Guige Hou,* Qingguo Meng and Ke Yan. Novel asymmetric 3,5-bis(arylidene)piperidin-4-one derivatives: synthesis, crystal structures and cytotoxicity. Acta Cryst. 2018. C74, 659–665. (SCI 收录，影响因子 8.678) (4) Ning Li, Binrong Yao, Chunhua Wang, Qingguo Meng and Guige Hou*. Synthesis, crystal structure and activity evaluation of novel 3,4-dihydro-1-benzoxepin-5(2H)-one derivatives as protein–tyrosine kinase (PTK) inhibitors. Acta Cryst. 2017. C73, 1003–1009. (SCI 收录，影响因子 8.678) (5) Xianrui Xie, Wei Cong, Feng Zhao, Hongjuan Li, Wenyu Xin, Chunhua Wang*, Gui-Ge Hou* , Synthesis, physiochemical property and antimicrobial activity of novel quaternary ammonium salts. J Enzyme Inhib Med Chem. 2017, 33(1):98-105. (SCI 收录，影响因子 3.638) (6) Chun-Hua Wang*, Xian-Rui Xie, Wen-Shuai Liu, Gui-Ge Hou* , Ju-Feng Sun, Feng Zhao, Wei Cong, Hong-Juan Li, Wen-Yu Xin, Quaternary ammonium salts substituted by 5-phenyl-1,3,4-oxadiazole-2-thiol as novel antibacterial agents with low cytotoxicity. Chemical Biology & Drug Design, 2017, 90(5), 943-952. (SCI 收录，影响因子 2.328) (7) Chun-Hua Wang*, Wen-Shuai Liu, Ju-Feng Sun, Gui-Ge Hou* , Qin Chen, Wei Cong, Feng Zhao, Non-toxic O-quaternized chitosan materials with better water solubility and antimicrobial function, International Journal of Biological Macromolecules, 2016, 84, 418-427. (SCI 收录，影响因子 3.671) (8) Qin Chen, Yun Hou, Gui-Ge Hou* , Ju-Feng Sun, Ning Li, Wei Cong, Feng Zhao, Hong Juan Li, Chun-Hua Wang*. Design, synthesis, anticancer activity and cytotoxicity of novel 4-piperidone/cyclohexanone derivatives. Research on Chemical Intermediates, 2016, 42(12): 8119-8130. (SCI 收录，影响因子 1.369) (9) Wen-Shuai Liu, Chun-Hua Wang*, Ju-Feng Sun, Gui-Ge Hou* , Yu-Peng Wang, Rong-Jun Qu. Synthesis, characterization and antibacterial properties of dihydroxy quaternary ammonium salts with long chain alkyl bromides. Chemical Biology & Drug Design, 2015, 85(1), 91–97. (SCI 收录，影响因子 2.802) (10) Hong-Juan Li, Lei Wang, Juan-Juan Zhao, Ju-Feng Sun, Ji-Liang Sun, Chun-Hua Wang, Gui-Ge Hou* . Synthesis, structure and luminescence of novel co-crystals based on bispyridyl-substituted α,β-unsaturated ketones with conformers. J Mol Struct, 2015, 1079, 414-422. (SCI 收录，影响因子 2.011) (11) Wei-Zhong Liu, Li-Ying Ma, De-Sheng Liu, Yu-Ling Huang, Chun-Hua Wang,* Shou-Sen Shi, Xiao-Hong Pan, Xiao-Dong Song, and Rong-Xiu Zhu, Peniciketals A−C, New Spiroketals from Saline Soil Derived Penicillium raistrichii. Org. Lett. 16, 90−93, 2014. (SCI 收录，影响因子 6.324). (12) Gui-Ge Hou* , Hui-Juan Zhao, Ju-Feng Sun, Dong Lin, Xian-Ping Dai, Jing-Tian Han, Hui Zhao. Synthesis, Structure and Luminescence of Co-crystals with Hexagonal Channels: Arranging Disposition and π-π Interactions. CrystEngComm, 2013, 15, 577-585. (SCI 收录，影响因子 3.849) (13) Gui-Ge Hou* , Chun-Hua Wang, Ju-Feng Sun, Mei-Zi Yang, Dong Lin, Hong-Juan Li. Rhodamine-based “turn-on” fluorescent probe with high selectivity for Fe2+ imaging in living cells. Biochem Biophys Res Co. 2013, 439, 459-463. (SCI 收录，影响因子 2.559) (14) Gui-Ge Hou* , Ju-Feng Sun, Chun-Hua Wang* , Feng Zhao, Xian-Ping Dai, Hong-Juan Li, Jing-Tian Han. Synthesis, structural characterization and luminescence studies of three novel complexes of asymmetric 5-(1-imidazolyl)pyrimidine ligand. J Mol Struct, 2013, 1048, 295-300. (SCI 收录，影响因子 2.011)