朱伟明 - 贵州医科大学

个人简介

正在承担或主持完成973、863、NSFC、国家“重大新药创制”专项等国家级研究课题25项，整合形成了以集成化学特性与生物活性为基础的药源微生物“Talented 菌株”的快速筛选技术体系；通过发酵优化和结构优化，发现新化合物700余个，其中8个新骨架化合物被Nat Prod Rep选为热点化合物；在《Journal of American Chemical Society》、《Organic Letters》、《Journal of Natural Products》、《Tetrahedron》等知名学术期刊上发表SCI收录的研究论文174篇，论文H-指数为41（Google Schoolar）、他引H-指数为32（Researchgate）；多次在国内外的学术大会上作大会报告、邀请报告或会议主持人；申请国家发明专利35件（授权14件、PCT2件）。获得2006中国药学会“施维雅青年药物化学奖”，入选贵州省2014年度“百人领军人才”，曾担任国家自然科学基金委员会（NSFC）第13、14届医学部药学学科专家组成员（“二审专家”），现任中国菌物学会菌物化学专业委员会副主任、中国海洋湖沼学会微生物海洋学分会常务理事、中国海洋生物化学与分子生物学分会理事、中国药学会海洋药物专业委员会委员、山东省药学会中药与天然药物专业委员会副主任委员、《中国抗生素》杂志编委、《中国海洋药物》杂志编委。

研究领域

天然药物化学与微生物药物化学研究，特别是特殊环境微生物中含氮和卤代天然产物的发现与优化。

近期论文

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1. Yiguang Zhu Qingbo Zhang, Sumei Li, Qinheng Lin, Peng Fu, Guangtao Zhang, Haibo Zhang, Rong Shi, Weiming Zhu*, and Changsheng Zhang*, Insights into caerulomycin A biosynthesis: a two-component monooxygenase CrmH-catalyzed oxime formation. J. Am. Chem. Soc., 2013, 135(50): 18750–18753（影响因子10.68） 2. Xia Li, Hongguang Ma, Lin Li, Yifan Chen, Xiao Sun, Zizheng Dong, Jing-Yuan Liu, Weiming Zhu,* Jian-Ting Zhang.* Novel synthetic bisindolylmaleimide alkaloids inhibit STAT3 activation by binding to the SH2 domain and suppress breast xenograft tumor growth. Oncogene 2018, 37(18): 2469–2480. doi:10.1038/s41388-017-0076-0（影响因子7.52） 3. Peng Fu, Yiguang Zhu, Xiangui Mei, Yi Wang, Haijian Jia, Changsheng Zhang*, Weiming Zhu*. Acyclic Congeners from Actinoalloteichus cyanogriseus Provide Insights into Cyclic Bipyridine Glycoside Formation. Org Lett 2014, 16(16): 4264–4267.（影响因子6.32） 4. Peng Fu, Fandong Kong, Xia Li, Yi Wang, Weiming Zhu*. Cyanogramide with a New Spiro[indolinone-pyrroloimidazole] Skeleton from Actinoalloteichus cyanogriseus. Org Lett 2014, 16(14): 3708–3711. 5. Peng Fu, Yibin Zhuang, Yi Wang, Peipei Liu, Xin Qi, Kangbo Gu, Daojing Zhang, Weiming Zhu*, New Indolocarbazoles from a mutant strain of the marine-derived actinomycete Streptomyces fradiae 007M135. Org Lett 2012, 14(24): 6194–6197. 6. Peng Fu, Chunli Yang, Yi Wang, Peipei Liu, Yiming Ma, Lei Xu, Mingbo Su, Kui Hong*, Weiming Zhu*, Streptocarbazoles A and B, two novel indolocarbazoles from the marine-derived actinomycete strain Streptomyces sp. FMA. Org Lett 2012, 14(9): 2422–2425. 7. Yiguang Zhu, Peng Fu, Qinheng Lin, Guangtao Zhang, Haibo Zhang, Sumei Li, Jianhua Ju, Weiming Zhu,* Changsheng Zhang*, Identification of caerulomycin A gene cluster implicates a tailoring amidohydrolase. Org Lett 2012, 14(11): 2666–2669. 8. Xiaoqiu Cui, Guoliang Zhu, Haishan Liu, Guoliang Jiang, Yi Wang*, Weiming Zhu*. Diversity and function of the Antarctic krill microorganisms from Euphausia superba. Sci. Rep. 2016, 6: 36496. （影响因子5.58） 9. Zhengbo Chen, Jiejie Hao, Liping Wang, Yi Wang*, Fandong Kong, Weiming Zhu*. New α-glucosidase inhibitors from marine algae-derived Streptomyces sp. OUCMDZ-3434. Sci Rep 2016, 6: 20004; 10. Yaqin Fan, Yi Wang, Peng Fu*, Arthit Chairoungdua, Pawinee Piyachaturawat, Weiming Zhu*. Secopaxilline A, an indole-diterpenoid derivative from an aciduric Penicillium fungus, its identification and semisynthesis. Org. Chem. Front. 2018, 5(19): 2835–2839. （影响因子5.46） 11. Yiguang Zhu, Jinxin Xu, Xiangui Mei, Zhan Feng, Liping Zhang, Qingbo Zhang, Guangtao Zhang, Weiming Zhu*, Jinsong Liu*, and Changsheng Zhang*. Biochemical and structural insights into the aminotransferase CrmG in caerulomycin biosynthesis. ACS Chem Biol 2016, 11(4): 943-952（影响因子5.33） 12. Miaomiao Wang, Shuyao Wang, Wei Wang*, Yi Wang, Hui Wang, Weiming Zhu*. Inhibition effects of novel polyketide compound PPQ-B against influenza A virus replication by interfering with the cellular EGFR pathway. Antiviral Research 2017, 143: 74–84.（影响因子4.91） 13. Liping Wang, Xiuli Han, Guoliang Zhu, Yi Wang, Arthit Chairoungdua, Pawinee Piyachaturawat, Weiming Zhu*. Polyketides from the endophytic fungus Cladosporium sp. isolated from the mangrove plant Excoecaria agallocha. Front. Chem. 2018, 6: 344. （影响因子4.16） 14. Haishan Liu, Guoliang Zhu, Yaqin Fan, Yuqi Du, Mengmeng Lan, Yibo Xu, Weiming Zhu*. Natural products research in China from 2015 to 2016. Front. Chem. 2018, 6: 45. 15. Dongyang Wang, Cong Wang, Pengyan Gui, Haishan Liu, Sameh M. H. Khalaf, Elsayed A. Elsayed, Mohammed A. M. Wadaan, Wael N. Hozzein*, Weiming Zhu*. Identification, bioactivity, and productivity of actinomycins from the marine-derived Streptomyces heliomycini. Front. Microbiol. 2017, 8: 1147. （影响因子4.02） 16. Tonghan Zhu, Zhenyu Lu, Jie Fan, Liping Wang, Guoliang Zhu, Yi Wang, Xia Li, Kui Hong, Pawinee Piyachaturawat, Arthit Chairoungdua, Weiming Zhu.* Ophiobolins from the mangrove fungus Aspergillus ustus. J Nat Prod 2018, 81(1): 2–9. （影响因子3.28） 17. Cong Wang, Lei Guo, Jiejie Hao, Liping Wang, Weiming Zhu*. α-Glucosidase inhibitors from the marine-derived fungus Aspergillus flavipes HN4-13. J Nat Prod 2016, 79(11): 2977-2981.