石磊 - 重庆大学 - 生命科学学院

个人简介

2001-2005 上海交通大学学士学位 2005-2010 中国科学院生物物理研究所博士学位

研究领域

研究肿瘤形成和迁移的分子机制，及其与机体免疫系统的互作关系。

近期论文

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Shi, L.*, Yu, L., Zou, F., Hu, H., Liu, K., & Lin, Z.* (2017). Gene expression profiling and functional analysis reveals that p53 pathway-related gene expression is highly activated in cancer cells treated by cold atmospheric plasma-activated medium. Peerj, 5:e3751. *Corresponding author Shi L*, Zhang W, Zou F, Mei L, Wu G, Teng Y*. KLHL21, a novel gene that contributes to the progression of hepatocellular carcinoma. BMC Cancer. 2016 Oct 21;16(1):815. *Corresponding author Shi L, Wu L, Wang S, Fan Z. Granzyme F induces a novel death pathway characterized by Bid-independent cytochrome c release without caspase activation. Cell Death and Differentiation 2009 Dec;16(12):1694-706. Zhang H, Zhong C, Shi L, Guo Y, Fan Z. Granulysin induces cathepsin B release of lysosomes of target tumor cells to target mitochondria through processing of Bid. Journal of Immunology 2009; 182(11):6993-7000. D Hu, S Liu, L Shi, L Wu, C Li, Z Fan. Cleavage of survivin by Granzyme M triggers degradation of the survivin-XIAP complex to free caspase activity leading to cytolysis of target tumor cells. Journal of Biological Chemistry 2010 Jun 11;285(24):18326-35. Guo Y*, Chen J*, Shi L, Fan Z. Valosin-containing protein cleavage by granzyme K accelerates an endoplasmic reticulum stress leading to caspase-independent cytotoxicity of target tumor cells. Journal of Immunology 2010; 185(9):5348-59. (*equal contribution) Wang S, Xia P, Shi L, Fan Z. FADD cleavage by NK cell granzyme M enhances its self-association to facilitate procaspase-8 recruitment for auto-processing leading to caspase cascade. Cell Death and Differentiation 2011; 19(4): p.605-15. Shi, GQ, QY Yu, L Shi, Z Zhang*. Molecular cloning and characterization of peroxiredoxin 4 involved in protection against oxidative stress in the silkworm Bombyx mori. Insect Mol Biol 2012; 21: 581-92