赫荣乔 - 中国科学院生物物理研究所 -

个人简介

1982年3月，毕业于四川省泸州医学院，1986年9月，获中国科学院微生物研究所硕士学位，1989年12月，获中国科学院生物物理研究所博士学位。1989年12月至今，在中国科学院生物物理研究所工作，研究员。曾留学及访问英国剑桥大学、加拿大McGill大学、意大利Pisa大学、美国纽约州基础研究所、美国西北大学研究所等。

研究领域

1. 胚胎早期发育的分子机制。研究脊椎动物大脑及视网膜神经细胞发生的调控机制，通过神经细胞增殖分化和神经退行性疾病相关编码基因及非编码RNA的筛选和功能分析，研究认知疾病发生发展机制。 2. 醛糖代谢失调与认知损伤的关系。提出和研究了“内源甲醛代谢失是老年认知损伤的危险因素”学说，发现内源甲醛与老年性痴呆病情的严重性呈正相关；验证了合理饮水可以清除体内包括甲醛在内的水溶性代谢产物，从而干预内源甲醛及其代谢产物在体内的蓄积；发现和研究了“2型糖尿病的核糖代谢失调”，强调核糖代谢失调与糖尿病并发症的密切关系，包括糖尿病脑病与老年痴呆，该工作将为老年痴呆的病理机制、早期诊断、早期治疗提供了新的研究途径。 3. 亚磁环境对大脑功能和发育的影响和机制。承担中科院重点支持的国际合作项目“模拟空间亚磁环境对大脑功能和发育的影响”研究，并与中科院空间中心自主研制建立了一套完善的亚磁场细胞培养和动物实验平台用于模拟空间亚磁场生物学效应和生物磁响应机制研究

近期论文

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1. Yu LX, Chen Y, Xu Y, He T, Wei Y, He RQ. D-ribose is elevated in T1DM patients and can be involved in the onset of encephalopathy. Aging (Albany NY), 2019, 11(14):4943-4969. 2. Wu BB, Wang YJ, Shi CG, Chen Y, Yu LX, Li J, Li WW, Wei Y, He RQ. Ribosylation-Derived Advanced Glycation End Products Induce Tau Hyperphosphorylation Through Brain-Derived Neurotrophic Factor Reduction. J Alzheimers Dis, 2019, 71(1):291-305. 3. Chen Y, Yu L, Wang Y, Wei Y, Xu Y, He T, He RQ. D-Ribose contributes to the glycation of serum protein. Biochim Biophys Acta Mol Basis Dis, 2019, 1865(9):2285-2292. 4. Wu BB, Yu LX, Hu PD, Lu Y, Li J, Wei Y, He RQ. GRP78 protects CHO cells from ribosylation. Biochim Biophys Acta Mol Cell Res, 2018, 1865:629-637. 5. Tong ZQ, Wang WS, Luo WH, Li H, Luo HJ, Jia JP, He RQ. Urine formaldehyde predicts cognitive impairment in post-stroke dementia and Alzheimer’s disease. J Alzheimers Dis. 2017, 55(3):1031-1038. 6. Chen XX, Su T, Chen Y, He YG, Liu Y, Xu Y, Wei Y, Li J, He RQ. D-ribose as a contributor to glycated haemoglobin, eBioMed. 2017, 25:143-153. 7. Zhang HT, Zhang ZJ, Mo WC, Hu PD, Ding HM, Liu Y, Hua Q, He RQ. Shielding of the geomagnetic field reduces hydrogen peroxide production in humanneuroblastoma cell and inhibits the activity of CuZn superoxide dismutase. Protein Cell. 2017, 8(7): 527-537. 8. Gao Q, Zhang JF, Wang XM, Liu Y, He RQ, Liu XF, Wang F, Feng J, Yang DL, Wang ZQ, Meng AM, Yan XY. The signaling receptor MCAM coordinates apical-basal polarity and planar cell polarity during morphogenesis. Nat Com. 2017, 8:15279. 9. Li T, Su T, He YG, Lu JH, Mo WC, Wei Y, He RQ. Brain formaldehyde is related to water intake behavior. Aging Dis. 2016, 7(5):561-584. 10. Wei Y, Han CS, Wang YJ, Wu BB, Su T, Liu Y, He RQ. Ribosylation triggering Alzheimer’s disease-like Tau hyperphosphorylation via activation of CaMKII. Aging Cell. 2015, 14(5):754-63. 11. Tong ZQ, Han CS, Qiang M, Wang WS, Lv JH, Zhang SZ, Luo WH, Li H, Luo HJ, Zhou HN, Wu BB, Su T, Yang X, Wang XM, Liu Y, He RQ. Age-related formaldehyde interferes with DNA methyltransferase function on causing memory loss in Alzheimer's disease. Neurobiol Aging. 2015, 36(1):100-10. 12. Han CS, Lu Y, Wei Y, Wu BB, Liu Y, He RQ. D-Ribosylation induces cognitive impairment through RAGE-dependent astrocytic inflammation. Cell Death Dis. 2014, 5, e1117. 13. Qiang M, Xiao R, Su T, Wu BB, Tong ZQ, Liu Y, He RQ. A Novel Mechanism for Endogenous Formaldehyde Elevation in SAMP8 Mouse. J Alzheimers Dis. 2014, 40(4):1039-53. 14. Yang MF, Lu J, Miao JY, Rizak J, Yang JZ, Zhai RW, Zhou J, Qu JG, Wang JH, Yang SC, Ma YY, Hu XT, He RQ. Alzheimer's Disease and Methanol Toxicity (Part 1): Chronic methanol feeding led to memory impairments and tau hyperphosphorylation in mice. J Alzheimers Dis. 2014, 41(4):1117-1129. 15. Yang MF, Miao JY, Rizak J, Zhai RW, Wang ZB, Huma T, Li T, Zheng N, Wu SH, Zheng YW, Fan XN, Yang JZ, Wang JH, Yang SC, Ma YY, Lv LB, He RQ, Hu XT. Alzheimer's Disease and Methanol Toxicity (Part 2): Lessons from Four Rhesus Macaques (Macaca mulatta) Chronically Fed Methanol. J Alzheimers Dis. 2014, 41(4):1131-47. 16. Qiang M, Xiao R, Su T, Wu BB, Tong ZQ, Liu Y, He RQ. A novel mechanism for endogenous formaldehyde elevation in SAMP8 mouse. J Alzheimers Dis. 2014. 40(4):1039-53. 17. Lu Y, He HJ, Zhou J, Miao JY, Lu J, He YG, Pan R, Wei Y, Liu Y, He RQ. Hyperphosphorylation results in tau dysfunction in DNA folding and protection. J Alzheimers Dis. 2013. 37:551-63. 18. Tong ZQ, Zhang JL, Luo WH, Li H, Luo HJ, Wang WS, Lu J, Zhou JN, Wan Y, He RQ. Urine formaldehyde level is inversely correlated to mini mental state examination scores in senile dementia. Neurobiol Aging. 2011, 32:31–41. 19. Liu YY, Qiang M, Wei Y, He RQ. A novel molecular mechanism for nitrated alpha-synuclein-induced cell death. J Mol Cell Biol. 2011, 3, 239–249. 20. Liu KL, Liu Y, Mo WC, Qiu R, Wang XM, Wu Y, He RQ. MiR-124 regulates early neurogenesis in the optic vesicle and forebrain by targeting NeuroD1. Nucleic acids Res. 2010, 39(7):2869-79.