丁劲松 - 中南大学 - 湘雅药学院

个人简介

教育经历： 1990-1994年，华西医科大学药学院（现四川大学华西药学院）药学专业，获学士学位。1997-2000年，华西医科大学药学院（现四川大学华西药学院）药剂学专业，获硕士学位。2003-2007年，中南大学药学院药理学专业（生物药剂学方向），获博士学位。工作经历： 1994-1995年，湖南医科大学湘雅医院（现中南大学湘雅医院），进修。1995-1997年，湖南医科大学附三院（现中南大学湘雅三医院）。2000-2004年，中南大学湘雅二医院。2004年-至今，中南大学药学院药剂学系。

研究领域

核酸适配体介导药物及诊断试剂纳米粒靶向传递系统研究；应用研究：缓控释制剂、药物经皮肤传递系统的研究，药物新剂型的研究与开发

近期论文

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[30]Li J, Mao J,Ding J*, et al. Surface spermidine functionalized PEGylatedpoly(lactide-co-glycolide) nanoparticles for tumor-targeted drug delivery[J].RSC Advances, 2017,7, 22954-22963. [29]Zhou W,Ding J, Liu J*. TheranosticDNAzymes[J].Theranostics, 2017, 7(4): 1010. [28]Zhou W,Ding J, Liu J*. 2-aminopurine-modified DNA homopolymers for robust and sensitive detection of mercury and silver[J].Biosensors and Bioelectronics, 2017, 87: 171-177. [27]Zhou W, Saran R, Huang P J J,Ding J, Liu J*. An Exceptionally Selective DNA Cooperatively Binding Two Ca2+ Ions[J].ChemBioChem, 2017, 18(6): 518-522. [26]Chen Y, Sun M,Ding J*, et al. SM-1, a novel PAC-1 derivative, activates procaspase-3 and causes cancer cell apoptosis[J].Cancer chemotherapy and pharmacology, 2016, 78(3): 643-654. [25]Zhou W,Ding J, Liu J*. A highly specific sodium aptamer probed by 2-aminopurine for robust Na+ sensing[J].Nucleic Acids Research, 2016,44(21):10377-10385. [24]Zhou W, Yu T, Vazin M,Ding J, Liu J*. Cr3+ Binding to DNA Backbone Phosphate and Bases: Slow Ligand Exchange Rates and Metal Hydrolysis[J].Inorganic chemistry, 2016, 55(16): 8193-8200. [23]Zhou W, Saran R, Chen Q,Ding J, Liu J*. A New Na+‐Dependent RNA‐Cleaving DNAzyme with over 1000‐fold Rate Acceleration by Ethanol[J].ChemBioChem, 2016, 17(2): 159-163. [22]Zhou W,Ding J, Liu J*. An Efficient Lanthanide‐Dependent DNAzyme Cleaving 2′–5′‐Linked RNA[J].ChemBioChem, 2016, 17(10): 890-894. [21]Zhou W, Zhang Y, Huang P J J,Ding J, Liu J*. A DNAzyme requiring two different metal ions at two distinct sites[J].Nucleic acids research, 2016, 44(1): 354-363. [20]Zhou W, Zhang Y,Ding J*, Liu J*. In Vitro Selection in Serum: RNA-Cleaving DNAzymes for Measuring Ca2+ and Mg2+[J].ACS Sensors, 2016, 1(5): 600-606. [19]Zhou W,Ding J, Liu J*. A Selective Na+ Aptamer Dissected by Sensitized Tb3+ Luminescence[J].ChemBioChem, 2016, 17(16): 1563-1570. [18]Zhou W, Vazin M, Yu T,Ding J, Liu J*. In Vitro Selection of Chromium‐Dependent DNAzymes for Sensing Chromium (III) and Chromium (VI)[J].Chemistry-A European Journal, 2016, 22(28): 9835-9840. [17]Qiu C, Wei W, Sun J, Zhang H,Ding J,et al. Systemic delivery of siRNA by hyaluronan-functionalized calcium phosphate nanoparticles for tumor-targeted therapy[J].Nanoscale, 2016, 8(26): 13033-13044. [16]Zhang Y, Tian D, Huang Y,Ding J*,et al. Pharmacokinetic evaluation of Shenfu Injection in beagle dogs after intravenous drip administration[J].ActaPharmaceuticaSinica B, 2016, 6(6): 584-592. [15]Zhou W,Ding J*, Liu J*. A platinum shell for ultraslow ligand exchange: unmodified DNA adsorbing more stably on platinum than thiol and dithiol on gold[J].Chemical Communications, 2015, 51(60): 12084-12087. [14]Zhou W, Chen Q, Huang P J J,Ding J*,Liu J*. DNAzyme hybridization, cleavage, degradation, and sensing in undiluted human blood serum[J].Analytical chemistry, 2015, 87(7): 4001-4007. [13]Liu Z, Zhao H, He L, Yao Y, Zhou Y,Ding J*,Liu J*. Aptamer density dependent cellular uptake of lipid-capped polymer nanoparticles for polyvalent targeted delivery of vinorelbine to cancer cells[J].RSC Advances, 2015,5(22): 16931-16939. [12]Tang J, Liu Z, Zhang Y, Li D,Ding J*,Xuehua Jiang*. Fluorofenidone-loaded PLGA microspheres for targeted treatment of paraquat-induced acute lung injury in rats[J].RSC Advances,2015, 5(38): 30153-30159. [11]Zhou W, He S, Yang Y, Jian D, Chen X,Ding J*. Formulation, characterization and clinical evaluation of propranolol hydrochloride gel for transdermal treatment of superficial infantile hemangioma[J].Drug development and industrial pharmacy, 2015, 41(7): 1109-1119. [10]Liu Z, Chen S, Liu B, Wu J, Zhou Y, He L,Ding J*,Liu J*. Intracellular detection of ATP using an aptamer beacon covalently linked to graphene oxide resisting nonspecific probe displacement[J].Analytical chemistry, 2014, 86(24): 12229-12235. [9] Zhou W, Wang F,Ding J*,Liu J*. Tandem phosphorothioate modifications for DNA adsorption strength and polarity control on gold nanoparticles[J].ACS applied materials & interfaces, 2014, 6(17): 14795-14800. [8] Liu Z, Liu B,Ding J, Liu J*. Fluorescent sensors using DNA-functionalized graphene oxide[J].Analytical and bioanalytical chemistry, 2014, 406(27): 6885-6902. [7] Zhou W, Huang P J J,Ding J*,Liu J*. Aptamer-based biosensors for biomedical diagnostics[J].Analyst, 2014, 139(11): 2627-2640. [6] Zhou W, Zhou Y, Wu J, Liu Z, Zhao H,Ding J*,Liu J*.Aptamer-nanoparticle bioconjugates enhance intracellular delivery of vinorelbine to breast cancer cells[J].Journal of drug targeting, 2014, 22(1): 57-66. [5] Xu S,Peng J,Li Y, He L, Chen F, Zhang J,DingJ*, et al. Pharmacokinetic comparisons of rutaecarpine and evodiamine after oral administration of Wu-Chu-Yu extracts with different purities to rats[J].Journal of ethnopharmacology, 2012, 139(2): 395-400. [4] Chen F, Li S, Li D,Ding J*. Transdermal behaviors comparisons among Evodiarutaecarpa extracts with different purity of evodiamine and rutaecarpine and the effect of topical formulation in vivo[J].Fitoterapia, 2012, 83(5): 954-960. [3] Tang J, Tan Z R, Zhou Y B,Ding J*. High-performance liquid chromatography-tandem mass spectrometry for the determination of trospium chloride in human plasma and its application in a bioequivalence study[J].Analytical Letters, 2011, 44(4): 607-616. [2] Ding J, Gao R, Li D, Peng J, Ran L, Li Y*. Solid dispersion of rutaecarpine improved its antihypertensive effect in spontaneously hypertensive rats[J].Biopharmaceutics & drug disposition, 2008, 29(9): 495-500. [1] Ding J*, Zhou Y, He J, Song J, Tan Z. Quantification of teprenone in human plasma by HPLC coupled to mass spectrometry: Application to a bioequivalence study[J].Chromatographia, 2007, 65(9-10): 533-538.