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个人简介

經歷: 2019國立清華大學副教授 2013~2019國立清華大學助理教授 2008~2013博士後研究:美國史克利普斯研究所 2001~2002中央研究院研究助理 2000~2001中華民國陸軍

研究领域

醣化學、生物有機化學、化學生物學

近期论文

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1.Wen HC, Lin CH, Huang JS, Tsai CL, Chen TF, Wang SK*.Selective targeting of DC-SIGN by controlling the oligomannose pattern on a polyproline tetra-helix macrocycle scaffold.Chem Commun. 2019, 55, 9124-9127. 2.Lin CH, Wen HC, Chiang CC, Huang JS, Chen Y, Wang SK* Polyproline Tri-Helix Macrocycles as Nanosized Scaffolds to Control Ligand Patterns for Selective Protein Oligomer Interactions.Small. 2019, 15, e1900561. 3.Tseng WH, Li MC, Horng JC, Wang SK* Strategy and Effects of Polyproline Peptide Stapling by Copper(I)-Catalyzed Alkyne-Azide Cycloaddition Reaction.ChemBioChem. 2019, 20, 153-158. 4.Huang KW, Lai YT, Chern GJ, Huang SF, Tsai CL, Sung YC, Chiang CC, Hwang PB, Ho TL, Huang RL, Shiue TY, Chen Y*, Wang SK*Galactose Derivative-Modified Nanoparticles for Efficient siRNA Delivery to Hepatocellular Carcinoma.Biomacromolecules. 2018, 19, 2330-2339. 5.Huang SF, Lin CH, Lai YT, Tsai CL, Cheng TR, Wang SK* Development of Pseudomonas aeruginosa Lectin LecA Inhibitor by using Bivalent Galactosides Supported on Polyproline Peptide Scaffolds. Chem Asian J. 2018, 13, 686-700. 6.Liu CH, Chern GG, Hsu FF, Huang KW, Sung YC, Huang HC, Qiu JT, Wang SK, Lin CC, Wu CH, Wu HC, Liu JY, Chen Y.* A multifunctional nanocarrier for efficient TRAIL-based gene therapy against hepatocellular carcinoma with desmoplasia.Hepatology. 2018, 67, 899-913. 7.Lin TH, Lin CH, Liu YJ, Huang CY, Lin YC, Wang SK* Controlling Ligand Spacing on Surface: Polyproline-Based Fluorous Microarray as a Tool in Spatial Specificity Analysis and Inhibitor Development for Carbohydrate-Protein Interactions. ACS Appl Mater Interfaces. 2017, 9, 41691-41699. 8.Wang SK,* Cheng CM.* Glycan-based diagnostic devices: current progress, challenges and perspectives.Chem Commun2015, 51, 16750-16762. 9.Doores KJ, Huber M, Le K, Wang SK, Doyle-Cooper C, Cooper A, Pantophlet R, Wong CH, Nemazee D, and Burton DR.2G12-expressing B cell lines inform HIV carbohydrate vaccine design strategies. J Virol2013, 87, 2234-2241. 10.Al-Shareffi E, Chaubard JL, Leonhard-Melief C, Wang SK, Wong CH, Haltiwanger RS. 6-Alkynyl fucose is a bioorthogonal analogue for O-fucosylation of epidermal growth factor-like repeats and thrombospondin type-1 repeats by protein O-fucosyltransferases 1 and 2. Glycobiology2013, 23, 188-198. 11.Pejchal R, Doores KJ, Walker LM, Khayat R, Huang PS, Wang SK, Stanfield RL, Julien JP, Ramos A, Crispin M, Depetris R, Katpally U, Marozsan A, Cupo A, Maloveste S, Liu Y, McBride R, Ito Y, Sanders RW, Ogohara C, Paulson JC, Feizi T, Scanlan CN, Wong CH, Moore JP, Olson WC, Ward AB, Poignard P, Schief WR, Burton DR, Wilson IA. A potent and broad neutralizing antibody recognizes and penetrates the HIV glycan shield. Science2011, 334, 1097-1103 12.Walker LM, Huber M, Doores KJ, Falkowska E, Pejchal R, Julien JP, Wang SK, Chan-Hui PY, Hammond PW, Olsen OA, Ramos A, Phung P,Wrin T, Simek MD, Fling S, Wong CH, Phogat S, Koff WC, Wilson IA, Burton DR, Poignard P. Redefining potency and breadth in antibody neutralization of HIV.Nature2011, 477, 466-470. 13.Liang CH,†Wang SK†(equal contribution), Lin CW, Wang CC, Wong CH, Wu CY, Effects of neighboring glycans on antibody-carbohydrate interaction.Angew Chem Int Ed. 2011, 50, 1608-1612. 14.Astronomo RD, Kaltgrad E, Udit AK, Wang SK, Doores KJ, Huang CY, Pantophlet R, Paulson JC, Wong CH, Finn MG, Burton DR. Defining criteria for oligomannose immunogens for HIV using icosahedral virus capsid scaffolds. Chem Biol. 2010,17, 357-370. 15.Wang SK, Liang PH, Astronomo RD, Hsu TL, Hsieh SL, Burton DR, Wong CH.Targeting the carbohydrates on HIV-1: Interaction of oligomannose dendrons with human monoclonal antibody 2G12 and DC-SIGN.Proc Natl Acad Sci USA2008,105, 3690-3695. 16.Liang PH, Wang SK, Wong CH.Quantitative analysis of carbohydrate-protein interactions using glycan microarrays: determination of surface and solution dissociation constants.J Am Chem Soc.2007,129, 11177-11184. 17.Hsu TL, Hanson SR, Kishikawa K, Wang SK, Sawa M, Wong CH.Alkynyl sugar analogs for the labeling and visualization of glycoconjugates in cells.Proc Natl Acad Sci USA. 2007, 104, 2614-2619. 18.Sanna MG†, Wang SK† (equal contribution), Gonzalez-Cabrera PJ, Don A, Marsolais D, Matheu MP, Wei SH, Parker I, Jo E, Cheng WC, Cahalan MD, Wong CH, Rosen H.Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo.Nat Chem Biol2006,2, 434-441. 19.Wu CY, Brik A,Wang SK, Chen YH, Wong CH. Tetrabutylammonium fluoride-mediated rapid alkylation reaction in microtiter plates for the discovery of enzyme inhibitors in situ.ChemBioChem2005, 6, 2176-2180. 20.Wei SH, Rosen H, Matheu MP, Sanna MG,Wang SK, Jo E, Wong CH, Parker I, Cahalan MD. Sphingosine 1-phosphate type 1 receptor agonism inhibits transendothelial migration of medullary T cells to lymphatic sinuses.Nat Immunol2005, 6, 1228-1235. 21.Liang FS,Wang SK, Nakatani T, Wong CH. Targeting RNAs with tobramycin analogues.Angew Chem Int Ed2004,43, 6496-6500.

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