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个人简介

工作经历 2017.1-pres. 中国科学院化学研究所 研究员 中科院活体分析化学重点实验室 2009 - 2017 中国科学院高能物理研究所 研究员 中国科学院纳米生物效应与安全性重点实验室 2005 - 2008 英国牛津大学 化学生物学博士后 纳米孔传感技术;纳米孔DNA测序 教育背景 2002 - 2005 英国剑桥大学 有机化学专业博士 有机不对称催化机理研究;有机膦配体的合成 1998 - 2001 北京大学 有机化学专业硕士 (S)-高苯丙氨酸的合成;铜催化的不对称反应研究 1994 - 1998 北京大学 有机化学专业学士

研究领域

1. 纳米孔技术用于生物化学中的单分子检测研究 2. 基于碳管纳米孔的高分辨传感器的构建 3. 人工离子通道的构建和应用研究

近期论文

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Hu WH, Zhou K, Liu, L, Wu H-C*. Construction of a pH‐Mediated Single‐Molecule Switch with a Nanopore‐DNA Complex. Small, 2022: 2201650.DOI10.1002/smll.202201650 Sheng Y, Zhou K, Liu L, Wu H-C*. A Nanopore Sensing Assay Resolves Cascade Reactions in a Multienzyme System[J]. Angewandte Chemie International Edition, 2022, 61(20): e202200866.DOI10.1002/anie.202200866 Zhao CJ, Li KJ, Mou XY, Zhu YB, Chen C, Zhang M, Wang Y, Zhou K, Sheng YY, Liu H, Bai YJ, Li XQ, Zhou CS, Deng D, Wu JP, Wu H-C*, Bao R, Geng J. High-fidelity biosensing of dNTPs and nucleic acids by controllable subnanometer channel PaMscS. Biosensors and Bioelectronics, 2022, 200: 113894. Zhang Y, Song P, Guo BY, Hao WY, Liu L, Wu H-C*. A bifunctional DNA probe for sensing pH and microRNA using a nanopore. Analyst, 2020, 145(21): 7025-7029.DOI10.1039/d1an90106k Guo BY, Song P, Zhou K, Liu L, Wu H-C*. Simultaneous sensing of multiple Cancer biomarkers by a single DNA Nanoprobe in a Nanopore. Analytical Chemistry, 2020, 92(13): 9405-9411. Sheng YY, Zhou K, Liu Q, Liu L, Wu H-C*. Probing conformational polymorphism of DNA assemblies with nanopores. Analytical Chemistry, 2020, 92(11): 7485-7492.DOI10.1021/acs.analchem.9b05650 Sheng Y, Zhang S, Liu L, Wu H-C*. Measuring enzymatic activities with nanopores. ChemBioChem, 2020, 21(15): 2089-2097.DOI10.1002/cbic.202000079 Liu L, You Y, Zhou K, Guo B, Cao Z, Zhao Y, Wu H-C*. A dual‐response DNA probe for simultaneously monitoring enzymatic activity and environmental pH using a nanopore. Angewandte Chemie International Edition, 2019, 131(42): 15071-15076.DOI10.1002/anie.201907816 Zhao Y, Liu L, Tu Y, Wu H-C*. Investigating the effect of mono‐and multivalent counterions on the conformation of poly (styrenesulfonic acid) by nanopores. Electrophoresis, 2019, 40(16-17): 2180-2185. You Y, Zhou K, Guo B, Liu Q, Cao Z, Liu L, Wu H-C*. Measuring binding constants of cucurbituril-based host–guest interactions at the single-molecule level with nanopores. ACS Sensors, 2019, 4(3): 774-779.DOI10.1021/acssensors.9b00408 Zhang Z, Li T, Sheng Y, Liu L, Wu H-C*. Enhanced sensitivity in nanopore sensing of cancer biomarkers in human blood via click chemistry. Small, 2019, 15(2): 1804078.DOI10.1002/smll.201804078 L. Liu, T. Li, S. Zhang, P. Song, B. Guo, Y. Zhao, H-C Wu*. Simultaneous Quantification of Multiple Cancer Biomarkers in Blood Samples through DNA-Assisted Nanopore Sensing. Angewandte Chemie International Edition. 2018, 57, 11882.DOI10.1002/anie.201803324 Yao Z , Ge W , Guo M , Xiao K, Qiao Y, Cao Z, Wu H-C*. Ultrasensitive detection of thiophenol based on a water-soluble pyrenyl probe. Talanta, 2018:146-150. DOI10.1016/j.talanta.2018.03.068 Wu X, Guo B, Sheng Y, Zhang Y, Wang J, Peng S, Liu L, Wu H-C*. Multiplexed discrimination of microRNA single nucleotide variants through triplex molecular beacon sensors. Chemical Communications, 2018, 54(55): 7673-7676.DOI10.1039/c8cc03574a Sheng Y, You Y, Cao Z, Liu L, Wu H-C*. Rapid and selective DNA-based detection of melamine using α-hemolysin nanopore. The Analyst, 2018, 143(10):2411.DOI10.1039/c8an00580j Guo B, Sheng Y, Zhou K, Liu Q, Wu H-C*. Analyte-Triggered DNA-Probe Release from a Triplex Molecular Beacon for Nanopore Sensing[J]. Angewandte Chemie, 2018.DOI10.1002/anie.201711690 Cheng H, LiZ, Huang Y, Liu L, Wu H-C*. Pillararene-based aggregation-induced-emission-active supramolecular system for simultaneous detection and removal of mercury (II) in water. ACS Applied Materials & Interfaces, 2017, 9(13): 11889-11894.DOI10.1021/acsami.7b00363 Qiao Y, Yao Z, Ge W, Zhang L, Wu H-C*. Rapid and visual detection of heparin based on the disassembly of polyelectrolyte-induced pyrene excimers. Organic & Biomolecular Chemistry, 2017, 15(12): 2569-2574.DOI10.1039/c7ob00115k Hu G, Cheng H, Niu J, Zhang Z, Wu H-C*. A multi-responsive molecular switch based on a diarylethene derivative containing dinitrobenzenesulfonic amide groups. Dyes and Pigments, 2017, 136: 354-360.DOI10.1016/j.dyepig.2016.08.072 Liu, L.; Wu H-C*, DNA-Based Nanopore Sensing. Angew. Chem. Int. Ed., 2016, 55, 15216-15222. Guo, B.; Yao, Z.; Liu, L.; Wu H-C*, Revealing different aggregational states of a conjugated polymer in solution by a nanopore sensor. Chem. Sci., 2016, 7, 5287-5293. Yao, Z.*; Qiao, Y.; Liang, H.; Ge, W.; Zhang, L.; Cao, Z.; Wu H-C*, Approach Based on Polyelectrolyte-Induced Nanoassemblies for Enhancing Sensitivity of Pyrenyl Probes. Anal. Chem., 2016, 88, 10605-10610. Liu, L.*; Li, Y.; Li, T.; Xie, J.; Chen, C.; Liu, Q.; Zhang, S.; Wu H-C*, Selective Detection of 8-Oxo-2'-deoxyguanosine in Single-Stranded DNA via Nanopore Sensing Approach. Anal. Chem., 2016, 88, 1073-1077. Cheng, H.-B.; Hu, G.-F.; Zhang, Z.-H.; Gao, L.; Gao, X.; Wu H-C*, Photocontrolled Reversible Luminescent Lanthanide Molecular Switch Based on a Diarylethene-Europium Dyad. Inorg. Chem., 2016, 55, 7962-7968.

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