个人简介
辛洪亮，男，药剂学博士，副教授，硕士研究生导师，药剂学副主任，中国药学会高级会员，中国药学会药剂专委会青年专家委员会委员，江苏省药剂专业委员会委员，Asian Journal of Pharmaceutical Sciences（AJPS）杂志青年编委，《南京医科大学学报》青年编委，国家自然科学基金通讯评审专家，Advanced Materials, Science Advances, ACS Nano, Advanced Functional Materials, JCR等杂志审稿专家，江苏省 “333”工程高层次人才，江苏省“六大人才高峰”，江苏省“双创计划”（科技副总），江苏省“青蓝工程” 优秀中青年学术带头人，南京医科大学优秀中青年学科（学术）带头人。江苏省“优青”获得者，2015.11-2016.11美国UNC&北卡罗莱纳州立大学联合生物医学工程系访问学者。近年来围绕脑部智能化药物递送策略及其制剂研究，主持国家自然科学基金面上项目、江苏省优青等各类纵向课题及横向课题十余项，在ACS Nano,Advanced Materials, Biomaterials, JCR等著名专业期刊发表高水平论文三十余篇，总引用2000余次，申请发明专利9项，已授权发明专利4项，已完成专利转让3项。
近期论文
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Keywords: borneol, blood-brain barrier penetration, paclitaxel, redox-responsive nanoparticles, CGKRK peptide. Citation: Lv L, Li X, Qian W, Li S, Jiang Y, Xiong Y, Xu J, Lv W, Liu X, Chen Y, Tang Y and Xin H (2020) Enhanced Anti-Glioma Efficacy by Borneol Combined With CGKRK-Modified Paclitaxel Self-Assembled Redox-Sensitive Nanoparticles. Front. Pharmacol. 11:558. doi: 10.3389/fphar.2020.00558
Enhanced Anti-Brain Metastasis from Non-Small Cell Lung Cancer of Osimertinib and Doxorubicin Co-Delivery Targeted Nanocarrier. Wang X, Mao W, Wang Z, Li X, Xiong Y, Lu H, Wang X, Yin H, Cao X, Xin H. International Journal of Nanomedicine 2020, 15:5491-5501
Sequentially Site-Specific Delivery of Thrombolytics and Neuroprotectant for Enhanced Treatment of Ischemic Stroke. Jianpei Xu, Xiaoqi Wang, Haoyuan Yin, Xiang Cao, Quanyin Hu, Wei Lv, Qunwei Xu, Zhen Gu*, and Hongliang Xin* ACS Nano 2019, 13, 8, 8577-8588
Bioengineered Boronic Ester Modified Dextran Polymer Nanoparticles as Reactive Oxygen Species Responsive Nanocarrier for Ischemic Stroke Treatment. Wei Lv, Jianpei Xu, Xiaoqi Wang, Xinrui Li, Qunwei Xu, and Hongliang Xin* ACS Nano 2018, 12, 6, 5417–5426
Sequentially Site-Specific Delivery of Thrombolytics and Neuroprotectant for Enhanced Treatment of Ischemic Stroke. Jianpei Xu, Xiaoqi Wang, Haoyuan Yin, Xiang Cao, Quanyin Hu, Wei Lv, Qunwei Xu, Zhen Gu*, and Hongliang Xin. doi: 10.1021/acsnano.9b01798
Jiang Yan, Wang Xiuzhen, Liu Xin, Lv Wei, Zhang Hongjuan, Li Xinrui, Xin Hongliang* , Xu Qunwei*. Enhanced Antiglioma Efficacy of Ultrahigh Loading Capacity Paclitaxel Prodrug Conjugate Self-Assembled Targeted Nanoparticles. ACS Appl Mater Interfaces. 2017, 9(1):211-217
Zhao Yue , Jiang Yan, Wei Lv, Wang Zhongyuan, Lv Lingyan, Wang Baoyan, Liu Xin, Liu Yang, Hu Quanyin, Sun Wujin, Xu Qunwei*, Xin Hongliang*, Gu Zhen. Dual targeted nanocarrier for brain ischemic stroke treatment. Journal of controlled release 2016, 233:64-71
Jiang Yan, Lv Lingyan, Shi Huihui, Hua Yabing, Lv Wei, Wang Xiuzhen, Xin Hongliang*, Xu Qunwei∗ PEGylated Polyamidoamine dendrimer conjugated with tumor homing peptide as a potential targeted delivery system for glioma. Colloids and Surfaces B: Biointerfaces 2016, 147:242-249
Lv Lingyan, Jiang Yan, Liu Xin, Wang Baoyan, Lv Wei, Zhao Yue, Shi Huihui, Hu Quanyin, Xin Hongliang*, Xu Qunwei*, Gu Zhen. Enhanced Antiglioblastoma Efficacy of Neovasculature and Glioma Cells Dual Targeted Nanoparticles. Mol. Pharmaceutics 2016, 13(10): 3506−3517
Wang, Baoyan; Lv, Lingyan; Wang, Zhi; Jiang,Yan; Lv,Wei; Liu,Xin; Wang, Zhongyuan; Zhao, Yue; Xin, Hongliang*; Xu, Qunwei*. Improved anti-glioblastoma efficacy by IL-13Rα2 mediated copolymer nanoparticles loaded with paclitaxel. Sci Rep. 2015 Nov 16;5:16589
Wang, Zhongyuan; Zhao,Yue; Jiang,Yan; Lv,Wei; Wu, Lin; Wang, Baoyan; Lv, Lingyan; Xu, Qunwei;* Xin, Hongliang* Enhanced anti-ischemic stroke of ZL006 by T7-conjugated PEGylated liposomes drug delivery system. Sci Rep. 2015 Jul 29;5:12651
Wang Baoyan, Lv Lingyan, Wang Zhongyuan, Zhao Yue, Wu Lin, Fang Xiaoling, Xu Qunwei*, Xin, Hongliang* Nanoparticles functionalized with Pep-1 as potential glioma targeting delivery system via Interleukin 13 receptor 2-mediated endocytosis. Biomaterials 2014, 35(22): 5897-5907
Jiang Xinyi, Xin, Hongliang; (Co-First Author), Gu, Jijin; Du, Fengyi; Feng, Chunlai; Xie, Yike; Fang, Xiaoling*. Enhanced Antitumor Efficacy by d-Glucosamine-Functionalized and Paclitaxel-Loaded Poly(Ethylene Glycol)-Co-Poly(Trimethylene Carbonate) Polymer Nanoparticles. J Pharm Sci. 2014, 103(5): 1487-1496
Jiang, Xinyi; Xin, Hongliang; (Co-First Author), Ren, Qiuyue; Gu, Jijin; Zhu, Lingjun; Du, Fengyi; Feng, Chunlai; Xie, Yike; Sha, Xianyi; Fang, Xiaoling*. Nanoparticles of 2-deoxy-d-glucose functionalized poly(ethylene glycol)-co-poly(trimethylene carbonate) for dual-targeted drug delivery in glioma treatment. Biomaterials 2014, 35(1): 518-529
Li Jing, Wu Ling, Wu Weijun, Wang Baoyan, Wang Zhongyuan, Xin Hongliang*, Xu Qunwei*. A potential carrier based on liquid crystal nanoparticles for ophthalmic delivery of pilocarpine nitrate. Int. J. Pharm. 2013, 455(1-2):75-84.
Wu Weijun, Li Jing, Wu Ling, Wang Baoyan, Wang Zhongyuan, Xu Qunwei*, Xin Hongliang*.Ophthalmic delivery of brinzolamide by liquid crystalline nanoparticles: in vitro and in vivo evaluation. AAPS Pharm SciTech 2013, 14(3):1063-1071.
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