个人简介
BSc (Hon), City University of Hong Kong
PhD, The Chinese University of Hong Kong
研究领域
Biochemistry of cancer, cardiovascular and neurodegenerative diseases.
Molecular pharmacology of Chinese medicine.
Systems biology: genome, transcriptome, proteome and protein interaction network
近期论文
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Li CW, Yu G, Jiang J, Lee SM, Yi C, Yue W, Yang M. A microfluidic linear node array for the study of protein-ligand interactions. Lab on a Chip. 2014 Sep 16;14(20):3993-9.
Ma, DL, He, HZ, Zhong HJ, Lin S, Chan, Daniel, Wang L, Lee, SM.Y, Leung, CH, Wong CY. Visualization of Zn2+ Ions in Live Zebrafish Using a Luminescent Iridium(III) Chemosensor. ACS Applied Materials & Interfaces. 2014 Aug 27;6(16):14008-15. Epub 2014 Aug 1.
Alba F.C. Torres, Cheng Huang, Cheong Meng Chong, Siu Wai Leung, Alvaro R. B. Prieto-da-Silva, Alexandre Havt, Yves P. Quinet, Alice M. C. Martins, Simon M. Y. Lee* & Gandhi Radis-Baptista*. Transcriptome analysis in venom gland of the predatory giant ant Dinoponera quadriceps: insights into the polypeptide toxin arsenal of hymenopterans. PLoS ONE. 2013 Jan 31;9(1):e87556.
Li ZH, Alex D, Siu SO, Chu IK, Renn J, Winkler C, Lou S, Tsui SK, Zhao HY, Yan WR, Mahady GB, Li GH, Kwan YW, Wang YT, Lee SM*. Combined in vivo imaging and omics approaches reveal metabolism of icaritin and its glycosides in zebrafish larvae. Mol Biosyst. 2011 7:2128-38. (Cover page, hot article)
S. Li, S. Lou, B. Lei, T.F. Chan, Y.W. Kwan, S.W. Chan, G. P.H. Leung, S.K.W. Tsui *, Lee S.M.**. Transcriptional Profiling of Angiogenesis Activities of Calycosin in Zebrafish. Mol BioSyst. 2011 7 (11): 312-3121.
Siu SO, Lam MP, Lau E, Kong RP, Lee SM, Chu IK*. Fully automatable two-dimensional reversed-phase capillary liquid chromatography with online tandem mass spectrometry for shotgun proteomics. Proteomics. 2011 Mar 29. doi:10.1002/pmic.201100110.
Kong RP, Siu SO, Lee SM, Lo C, Chu IK*. Development of online high-/low-pH reversed-phase-reversed-phase two-dimensional liquid chromatography for shotgun proteomics: A reversed-phase-strong cation exchange-reversed-phase approach. J Chromatogr A. 2011 Jun 10;1218(23):3681-8.
Rodriguez AA, Cassoli JS, Sa F, Dong ZQ, Freitas JC , Pimenta AMC, Lima ME, Konno K, Lee SM, Garateix A and Zaharenko AJ. Peptide fingerprinting of the neurotoxic fractions isolated from the secretions of sea anemones Stichodactyla helianthus and Bunodosoma granulifera. New members of the APETxlike family identified by a 454 pyrosequencing approach. Peptides.2012 Mar;34 (1):26-38.
Zhao H, Deneau J, Che GO, Li S, Vagnini F, Azadi P, Sonon R, Lee SM, Bojanowski K. Angelica sinensis Isolate SBD.4: Composition, Gene Expression Profiling, Mechanism of Action, and Effect on Wounds in Rats and Humans. Eur J Dermatol. 2012 Jan-Feb;22(1):58-67.?
Wong CH, Fung YW, Ng EK, Lee SM, Waye MM, Tsui SK*. LIM domain protein FHL1B interacts with PP2A catalytic β subunit -A novel cell cycle regulatory pathway. FEBS Lett. 2010 Nov 19; 584(22):4511-6.
Mils V, Lee SM, Joly W, Wong EW, Baldin V, Waye MM, Ducommun B, and Tsui SK. The LIM-only protein FHL3 interacts with CDC25B2 Phosphatase. Experimental Cell Research. 2003;285:99-106
Ng EK, Chan KK, Wong CH, Tsui SK, Ngai SM, Lee SM, Kotaka M, Lee CY, Waye MM, Fung KP. Interaction of the heart-specific LIM domain protein, FHL2, with DNA-binding nuclear protein, hNP220. J Cell Biochem.2002; 84:556-66.
Li HY, Kotaka M, Kostin S, Lee SM, Kok LD, Chan KK, Tsui SK, Schaper J, Zimmermann R, Lee CY, Fung KP, Waye MM. Translocation of a human focal adhesion LIM-only protein, FHL2, during myofibrillogenesis and identification of LIM2 as the principal determinants of FHL2 focal adhesion localization. Cell Motil Cytoskeleton. 2001 Jan;48(1):11-23.
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