杨劲松 - 四川大学 - 华西药学院

个人简介

学习和研究工作简历 1988年9月—1992年7月：四川大学化学系化学专业本科。 1992年9月—1995年7月：南开大学化学系有机化学专业硕士生。 1995年9月—1998年7月：华西医科大学药学院药物化学专业博士生。 1998年9月—1998年12月：华西医科大学药学院天然药物化学教研室助教。 1998年12月—1999年12月：在日本东邦大学药学部村上泰兴教授的研究组进行博士后研究。 2000年1月—2001年6月：四川大学华西药学院天然药物化学教研室讲师。 2001年7月—2007年6月：四川大学华西药学院天然药物化学教研室副教授。 2007年7月至今：四川大学华西药学院天然药物学系教授，博士研究生导师。入选2008年度教育部新世纪优秀人才支持计划以及四川省杰出青年学科带头人培养计划。研究方向为糖化学，以通讯作者身份发表SCI研究论文20余篇；近5年来，作为课题负责人承担了3项国家自然科学基金面上项目，参编出版两种本科教材。两次荣获四川大学青年骨干教师奖励。

研究领域

糖化学近年来主持的纵向课题 1.基于氢键活化策略的β-L-鼠李糖苷化和α-D-唾液酸糖苷化反应研究，国家自然科学基金面上项目(21772132)；2018-2021。 2.立体选择性合成Kdo糖苷键的新方法及其应用研究，国家自然科学基金面上项目(21572145)；2016-2019。 3.阿拉伯和半乳呋喃寡糖合成新方法及其应用研究，国家自然科学基金面上项目(21372166)；2014-2017。 4.抗alpha-正链RNA病毒活性成分芫花叶白前苷元C及其皂苷的全合成，国家自然科学基金面上项目(21172156)；2012-2015。 5.以曲二糖为模板的α-葡萄糖苷酶抑制剂的设计、合成及活性研究，教育部新世纪优秀人才支持计划(NCET-08-0377)；2009-2011。 6.新型二糖类α-葡萄糖苷酶抑制剂的设计、合成及活性研究，教育部博士点基金(20100181110082)；2011-2013。 7.曲二糖类似物的合成及其α-葡萄糖苷酶抑制活性研究，2008年度四川省杰出青年学科带头人培养计划(08ZQ026-029)；2008-2010。

近期论文

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Wei Huang, Ying-Yu Zhou, Xing-Ling Pan, Xian-Yang Zhou, Jin-Cai Lei, Dong-Mei Liu, Yue Chu, Jin-Song Yang*. Stereodirecting Effect of C5-Carboxylate Substituents on the Glycosylation Stereochemistry of 3?Deoxy-D-manno-oct-2-ulosonic Acid (Kdo) Thioglycoside Donors: Stereoselective Synthesis of α- and β?Kdo Glycosides, J. Am. Chem. Soc. 2018, 140, 3574. Yuan Xu, Hua-Chao Bin, Fu Su, Jin-Song Yang*. Stereoselective synthesis of aryl 1,2-cis-furanosides and its application to the synthesis of the carbohydrate portion of antibiotic hygromycin A, Tetrahedron Lett. 2017, 58, 1548. Peng-Cheng Gao, San-Yong Zhu, Hui Cao, Jin-Song Yang*. Total Synthesis of Marine Glycosphingolipid Vesparioside B, J. Am. Chem. Soc. 2016, 138, 1684. Kai Zhu, Jin-Song Yang*. Synthesis of tri- and tetrasaccharide glycosides of (4S)-4-hydroxy-D-proline relevant to the cell wall O-glycans of green alga Chlamydomonas reinhardtii, Tetrahedron 2016, 72, 3113. Jia-Sheng Huang, Wei Huang, Xue Meng, Xin Wang, Peng-Cheng Gao, Jin-Song Yang*. Stereoselective Synthesis of α-3-Deoxy-D-manno-oct-2-ulosonic Acid (α-Kdo) Glycosides Using 5,7-O-Di-tert-butylsilylene-Protected Kdo Ethyl Thioglycoside Donors, Angew. Chem. Int. Ed. 2015, 54, 10894. Shuai Wang, Xue Meng, Wei Huang, Jin-Song Yang*. Study on the Influence of Silyl Protections on the Anomeric Reactivity of Galactofuranosyl Thioglycosides and Application of the Silylated Thiogalactofuranosides to One-Pot Synthesis of Diverse β-D-Oligogalactofuranosides, J. Org. Chem. 2014, 79, 10203. San-Yong Zhu, Jia-Sheng Huang, Shan-Shan Zheng, Kai Zhu, Jin-Song Yang*. First Total Synthesis of the Proposed Structure of Batatin VI, Org. Lett. 2013, 15, 4154. Qiang-Wei Liu, Hua-Chao Bin, Jin-Song Yang*. β-Arabinofuranosylation Using 5-O-(2-Quinolinecarbonyl) Substituted Ethyl Thioglycoside Donors, Org. Lett. 2013, 15, 3974. Xing-Yong Liang, Hua-Chao Bin, Jin-Song Yang*. Tuning Effect of Silyl Protecting Groups on the Glycosylation Reactivity of Arabinofuranosyl Thioglycoside, Org. Lett. 2013, 15, 2834. Xing-Yong Liang, Qiang-Wei Liu, Hua-Chao Bin, Jin-Song Yang*. One-Pot Synthsis of Branched Oligosaccharide by Use of Galacto- and Mannopyranosyl Thioglycoside Diols as Key Glycosylating Agent, Org. Biomol. Chem. 2013, 11, 3903. Xing-Yong Liang, Li-Ming Deng, Jin-Song Yang*. Review on Synthesis and Occurrence of Oligoaranbino-, Oligogalacto- and Oligofructo furanoses, Chin. J. Org. Chem. 2013, 33, 245. Jia Shao, Jin-Song Yang*. A Diastereoselective Cyclic Imine Cycloaddition Strategy to Access Polyhydroxylated Indolizidine Skeleton: Concise Syntheses of (+)-/(–)-Lentiginosines and (–)-2-epi-Steviamine, J. Org. Chem. 2012, 77, 7891. San-Yong Zhu, Jin-Song Yang*. Synthesis of Tetra- and Hexasaccharide Fragments Corresponding to the O-Antigenic Polysaccharide of Klebsiella Pneumoniae, Tetrahedron 2012, 68, 3795. Li-Min Deng, Xia Liu, Xing-Yong Liang, Jin-Song Yang*. Regioselective Glycosylation Method Using Partially Protected Arabino- and Galactofuranosyl Thioglycosides as Key Glycosylating Substrates and Its Application to One-Pot Synthesis of Oligofuranoses, J. Org. Chem. 2012, 77, 3025. Lin Xie, San-Yong Zhu, Xiao-Qiu Shen, Li-Li He, Jin-Song Yang*. Total Synthesis of Batatoside L, J. Org. Chem. 2010, 75, 5764. Xing-Yong Liang, Li-Min Deng, Xia Liu, Jin-Song Yang*. Efficient One-pot Syntheses of α-D-Arabinofuranosyl Tri- and Tetrasaccharides Present in Cell Wall Polysaccharide of Mycobacterium Tuberculosis, Tetrahedron 2010, 66, 87. Xiao-Qiu Shen, Lin Xie, Liang Gao, Li-Li He, Qian Yang, Jin-Song Yang*. Synthetic Studies on the Trisaccharide Intermediate of Resin Glycoside Merremoside H2, Carbohydr. Res. 2009, 344, 2063. Ming Lei, Liang Gao, Jin-Song Yang*. Microwave-assisted Palladium-catalyzed Cross-coupling Reactions between Pyranoid Glycals and Aryl Bromides. Synthesis of 20-Deoxy C-Aryl-β-glycopyranosides, Tetrahedron Lett. 2009, 50, 5135. Qian Yang; Ming Lei; Qin-Jian Yin; Jin-Song Yang*. Silver(I) oxide-mediated Regioselective 2-Monoacylation in 3-O-Benzyl-α-L-rhamnopyranosides and Application in Synthesis of a Protected Tetrasaccharide Fragment of Potent Cytotoxic Saponins Gleditsiosides C and D, Carbohydr. Res. 2007, 342, 1175. Qiang Tian, Xing-Mei Zhu, Jin-Song Yang*. Amberlyst 15-Catalyzed Efficient Synthesis of 2,3-Unsaturated Glycosides via Ferrier Rearrangement for Glycal. Synth. Commun. 2007, 37, 691.