张海元 - 中国科学院长春应用化学研究所 -

个人简介

工作经历： 2014年~至今：中科院长春应用化学研究所化学生物学实验室； 2009年~2013年：美国加州大学洛杉矶分校；职位：研究助理 2008年~2009年：美国伦斯勒理工学院；职位：博士后 2005年~2007年：美国韦恩州立大学；职位：博士后教育背景： 1999年~2005年：中科院长春应用化学研究所；攻读博士学位 1995年~1999年：山西大学化学系；攻读学士学位

研究领域

我们致力于发展新的模型典范，用于理解纳米材料与生物系统相互作用；我们也致力于开拓革新的策略，促进纳米材料的生物医学应用。合成化学、材料化学、分子生物学、细胞生物学和动物生物学等多种学科被交叉应用，促进基础研究、原理验证与阐释及产品的产出。我们当前着重关注于具有优良光电子特性的纳米材料对于生物体系及疾病的操控。

近期论文

查看导师最新文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Liu, X.; Feng, Y.; Xu, G.; Chen, Y.; Luo, Y.; Song, J.; Bao, Y.; Yang, J.; Yu, C.; Li, Y.; Ye, H.; Ke, B.; Chen, B.; Hu, J.; Xu, J.; Meng, H.; Zhang, H.*; Shi, H.*, MAPK-Targeted Drug Delivered by a pH-Sensitive MSNP Nanocarrier Synergizes with PD-1 Blockade in Melanoma without T-Cell Suppression. Advanced Functional Materials 2019, 1806916. Feng, Y.; Chang, Y.; Sun, X.; Cheng, Y.; Zheng, R.; Wu, X.; Wang, L.; Ma, X.; Li, X.; Zhang, H.*, Differential photothermal and photodynamic performance behaviors of gold nanorods, nanoshells and nanocages under identical energy conditions. Biomaterials Science 2019. Cheng, Y.; Chang, Y.; Feng, Y.; Jian, H.; Wu, X.; Zheng, R.; Xu, K.; Zhang, H.*, Bismuth Sulfide Nanorods with Retractable Zinc Protoporphyrin Molecules for Suppressing Innate Antioxidant Defense System and Strengthening Phototherapeutic Effects. Advanced Materials 2019, 1806808. Zheng, R. X.; Tao, L.; Jian, H.; Chang, Y.; Cheng, Y.; Feng, Y. L.; Zhang, H. Y.*, NLRP3 inflammasome activation and lung fibrosis caused by airborne fine particulate matter. Ecotoxicology and Environmental Safety 2018, 163, 612-619. Wu, M. X.; Yan, H. J.; Gao, J.; Cheng, Y.; Yang, J.; Wu, J. R.; Gong, B. J.; Zhang, H. Y.; Yang, Y. W.*, Multifunctional Supramolecular Materials Constructed from Polypyrrole@UiO-66 Nanohybrids and Pillararene Nanovalves for Targeted Chemophotothermal Therapy. Acs Applied Materials & Interfaces 2018, 10, 34655-34663. Wang, X.; Yang, J.; Sun, X. J.; Yu, H. L.; Yan, F.; Meguellati, K.; Cheng, Z. Y.; Zhang, H. Y.; Yang, Y. W.*, Facile surface functionalization of upconversion nanoparticles with phosphoryl pillar 5 arenes for controlled cargo release and cell imaging. Chemical Communications 2018, 54, 12990-12993. Sun, X. J.; Chang, Y.; Cheng, Y.; Feng, Y. L.; Zhang, H. Y.*, Band Alignment-Driven Oxidative Injury to the Skin by Anatase/Rutile Mixed-Phase Titanium Dioxide Nanoparticles Under Sunlight Exposure. Toxicological Sciences 2018, 164, 300-312. Cheng, Y.; Zhang, H. Y.*, Novel Bismuth-Based Nanomaterials Used for Cancer Diagnosis and Therapy. Chemistry-a European Journal 2018, 24, 17405-17418. Cheng, Y.; Chang, Y.; Feng, Y. L.; Jian, H.; Tang, Z. H.; Zhang, H. Y.*, Deep-Level Defect Enhanced Photothermal Performance Of Bismuth Sulfide-Gold Heterojunction Nanorods For Photothermal Therapy Of Cancer Guided By Computed Tomography Imaging. Angew. Chem.-Int. Edit. 2018, 57, 246-251. Chang, Y.; Cheng, Y.; Feng, Y.; Jian, H.; Wang, L.; Ma, X.; Li, X.; Zhang, H. *, Resonance Energy Transfer-Promoted Photothermal And Photodynamic Performance Of Gold–Copper Sulfide Yolk–Shell Nanoparticles For Chemophototherapy Of Cancer. Nano Letters 2018, 18, 886-897. Liu, N.; Chang, Y.; Feng, Y. L.; Cheng, Y.; Sun, X. J.; Jian, H.; Feng, Y. Q.; Li, X.; Zhang, H. Y. *, {101}-{001} Surface Heterojunction-Enhanced Antibacterial Activity Of Titanium Dioxide Nanocrystals Under Sunlight Irradiation. ACS Appl. Mater. Interfaces 2017, 9, 5907-5915. Feng, Y. L.; Chang, Y.; Sun, X. J.; Liu, N.; Cheng, Y.; Feng, Y. Q.; Zhang, H. Y. *; Li, X. *, Understanding The Property-Activity Relationships Of Polyhedral Cuprous Oxide Nanocrystals In Terms Of Reactive Crystallographic Facets. Toxicol. Sci. 2017, 156, 480-491. Cheng, Y.; Chang, Y.; Feng, Y. L.; Liu, N.; Sun, X. J.; Feng, Y. Q.; Li, X.; Zhang, H. Y. *, Simulated Sunlight-Mediated Photodynamic Therapy For Melanoma Skin Cancer By Titanium-Dioxide-Nanoparticle-Gold-Nanocluster-Graphene Heterogeneous Nanocomposites. Small 2017, 13, 12. Chang, Y.; Li, K.; Feng, Y. L.; Cheng, Y.; Zhang, M.; Wang, Z. K.; Wu, Z. J. *; Zhang, H. Y. *, Achievement Of Safer Palladium Nanocrystals By Enlargement Of {100} Crystallographic Facets. Nanotoxicology 2017, 11, 907-922. Liu, N.; Li, K.; Li, X.; Chang, Y.; Feng, Y. L.; Sun, X. J.; Cheng, Y.; Wu, Z. J. *; Zhang, H. Y. *, Crystallographic Facet-Induced Toxicological Responses By Faceted Titanium Dioxide Nanocrystals. Acs Nano 2016, 10, 6062-6073. Chang, Y.; Li, K.; Feng, Y. L.; Liu, N.; Cheng, Y.; Sun, X. J.; Feng, Y. Q.; Li, X. *; Wu, Z. J. *; Zhang, H. Y. *, Crystallographic Facet-Dependent Stress Responses By Polyhedral Lead Sulfide Nanocrystals And The Potential "Safe-By-Design" Approach. Nano Res. 2016, 9, 3812-3827. Zhang, H.; Wang, X.; Wang, M.; Li, L.; Chang, C. H.; Ji, Z.; Xia, T.; Nel, A. E. *, Mammalian Cells Exhibit A Range Of Sensitivities To Silver Nanoparticles That Are Partially Explicable By Variations In Antioxidant Defense And Metallothionein Expression. Small 2015, 11, 3797-3805. Wang, X.; Duch, M. C.; Mansukhani, N.; Ji, Z.; Liao, Y.-P.; Wang, M.; Zhang, H.; Sun, B.; Chang, C. H.; Li, R.; Lin, S.; Meng, H.; Xia, T.; Hersam, M. C.; Nel, A. E. *, Use Of A Pro-Fibrogenic Mechanism-Based Predictive Toxicological Approach For Tiered Testing And Decision Analysis Of Carbonaceous Nanomaterials. Acs Nano 2015, 9, 3032-3043. Sun, B.; Wang, X.; Ji, Z.; Wang, M.; Liao, Y.-P.; Chang, C. H.; Li, R.; Zhang, H.; Nel, A. E.; Xia, T. *, NADPH Oxidase-Dependent NLRP3 Inflammasome Activation And Its Important Role In Lung Fibrosis By Multiwalled Carbon Nanotubes. Small 2015, 11, 2087-2097. Sun, B.; Pokhrel, S.; Dunphy, D. R.; Zhang, H.; Ji, Z.; Wang, X.; Wang, M.; Liao, Y.-P.; Chang, C. H.; Dong, J.; Li, R.; Maedler, L.; Brinker, C. J.; Nel, A. E.; Xia, T. *, Reduction Of Acute Inflammatory Effects Of Fumed Silica Nanoparticles In The Lung By Adjusting Silanol Display Through Calcination And Metal Doping. Acs Nano 2015, 9, 9357-9372. Low-Kam, C.; Telesca, D.; Ji, Z.; Zhang, H.; Xia, T.; Zink, J. I.; Nel, A. E. *, A BAYESIAN REGRESSION TREE APPROACH TO IDENTIFY THE EFFECT OF NANOPARTICLES' PROPERTIES ON TOXICITY PROFILES. Annals Of Applied Statistics 2015, 9, 383-401.