肖智雄 - 四川大学 - 生命科学学院

个人简介

四川大学生物系生物化学专业获理学学士学位(1982年)和理学硕士学位（1985年）。四川大学生物系助教(1985) 教育部中美生化和分子生物学留美项目（CUSBMBEA）选拔获选，留学美国（1986）获美国麻省大学（University of Massachusetts at Amherst）分子生物学博士学位（1990）哈佛大学博士后（1991-1995）美国波士顿大学医学院生化系和医学系助理教授（1996），副教授（2001），正教授（2007）。第四军医大学客座教授（1998-2002）中国协和医科大学客座教授(1999-2004) 四川大学客座教授（1998-2004）。中央党校培训班（2010，4）获奖： 1991获美国Anna Fuller基金会的博后研究奖， 1995美国癌症学会资深博后研究学者奖。2006 年收入美国名人录. 获多项美国NIH独立研究员研究项目资金，美国国防部癌症研究专项基金，美国癌症协会项目研究基金以及美国麻州癌症研究专项基金，波士顿大学医学院WING TANG LEE 基金会研究基金。试验室有4名博士后和6名博士生分别获美国NIH博士后/博士研究奖，美国国防部乳腺癌研究博士研究基金，波士顿大学最佳博士论文墙报奖，以及波士顿大学医学院最佳论文奖。

研究领域

研究方向: 肿瘤分子生物学，信号传递，细胞生长代谢与衰老，转化医学研究内容: 抗肿瘤基因 p53 和 Rb 及家族成员的功能和调控 DNA 损伤和细胞胁迫对细胞生长，调控，代谢和衰老的调控及信号传导通路蛋白质磷酸化，乙酰化，泛素化及甲基化对肿瘤发生重要蛋白的调控基因表达调控，计算机生物模型及其运用抗癌药物筛选和鉴定。转化医学应用研究。

近期论文

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Hiroyuki Inuzuka, Alan Tseng, Daming Gao, Bo Zhai, Qing Zhang, Shavali Shaik, Lixin Wan, Xiaolu L. Ang, Caroline Mock, Haoqiang Yin, Jayne M. Stommel, Steven Gygi, Galit Lahav, John Asara, Zhi-Xiong Jim Xiao, William G. Kaelin, Jr., J. Wade Harper and Wenyi Wei. Phosphorylation by Casein Kinase I Promotes the Turnover of the Mdm2 Oncoprotein via the SCFb-TRCP Ubiquitin Ligase. Cancer Cell, in press. Du, W., Wu, J., Walsh, EM., Zhang, Y., Chen, CY., and Xiao ZX, Nutlin-3a affects expression and function of retinoblastoma protein: a role of retinoblastoma protein in cellular response to nutlin-3a. J. Biol. Chem. 284: 26315-26321, 2009. Qiu, W., Wu, J., Walsh, W. M., Zhang, Y., Chang, C-Y., Fujita, J., and Xiao ZX. Retinoblastoma protein modulates gankyri-MDM2 in regulation of p53 stability and chemosensitivity in cancer cells. Oncogene 27:4034-4043, 2008. Jin Y, Zeng SX, Sun XX, Lee H, Blattner C, Xiao Z, Lu H. MDMX promotes proteasomal turnover of p21 at G1 and early S phases independently of, but in cooperation with MDM2. Mol. Cell. Biol. 28:1218-1229, 2008. Chang, DLF., Qiu, W.. Ying, H., Zhang, Y., Chen, CY., and Xiao ZX. ARF promotes accumulation of retinoblastoma protein through inhibition of MDM2. Oncogene 26: 4627-4634, 2007. Ying, H. and Xiao, ZX. Targeting retinoblastoma protein for degradation by proteasomes. Cell Cycle 5:506-508, 2006. Ying, H., Chang, DL., Zheng, H., McKeon, F., and Xiao, Z.X. The DNA-binding and transactivation activities are essential for TAp63 protein degradation. Mol. Cell. Biol. 25:6154-6164, 2005. Sdek, P., Ying, H., Chang, DL., Qiu, W., Zheng, H., Allday, MJ and Xiao, Z.X. MDM2 promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma protein. Mol. Cell 20:699-708, 2005. Sdek, P., Ying, H., Zheng, H., Margulis, A., Tang, X., Tian, K. and Xiao. Z.X. The central acidic domain of MDM2 is critical in inhibition of retinoblastoma -mediated suppression of E2F and cell growth. J. Biol. Chem. 279: 53317-22. 2004 Murray, S.A., Zheng, H., Gu, L. and Xiao, Z.X. IGF-1 activates p21 to inhibit UV-induced cell death. Oncogene 22: 1703-1711, 2003. Zheng, H., You, H., Zhou, X. Z., Murray, S.A., Uchida, T., Wulf, G., Gu, L., Tang, X., Lu, K.P. and Xiao, Z.X. The Prolyl isomerase Pin1 is a novel regulator of p53 in genotoxic response. Nature 419: 849-853 (with News and Views 419:795-797), 2002. Xiao, Z.X., Chen, J., Levine, A. J., Modjtahedi, N., Xing, J., Sellers, W. R. and Livingston, D. M. Interaction between the retinoblastoma protein and the oncoprotein MDM2. Nature, 375, 694-698, 1995. Xiao, Z.X. Ginsberg, D., Ewen, M. and Livingston, D. M. Regulation of the Grossman, S.R., Perez, M., Joseph, M., Mansur, C., Xiao, Z.X., Kumar, S., Howley, P.M. and Livingston, D.M. p300/MDM2 complexes participate in MDM2-mediated p53 degradation. Mol. Cell 2: 405-415, 1998. Xiao, Z.X. Ginsberg, D., Ewen, M. and Livingston, D. M. Regulation of the retinoblastoma protein-related protein p107 by G1 cyclin-associated kinases. Proc. Natl. Acad. Sci. USA. 93, 4633-4637, 1996.