杨献文 - 自然资源部第三海洋研究所 -

个人简介

杨献文，博士，自然资源部第三海洋研究所研究员。中国药学会海洋药物专业委会会委员、中国药理学会海洋药物药理专业委员会委员、中国海洋湖沼学会海洋生物技术分会委员、中国菌物学会菌物化学专业委员会委员。先后任中国科学院南海海洋研究所副研究员、卢森堡健康研究院研究员。在国际上拥有广泛的学术影响，受邀担任Frontiers in Chemistry客座副主编、Chinese Chemical Letters青年编委、Chemistry & Biodiversity编委。同时也是Organic Letters, Journal of Natural Products等多个国际期刊的资深审稿人。

研究领域

深海微生物天然产物研究

近期论文

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Xie, C. L.; Zhang, D.; Guo, K. Q.; Yan, Q. X.; Zou, Z. B.; He, Z. H.; Wu, Z.; Zhang, X. K.; Chen, H. F.; Yang, X. W.* Meroterpenthiazole A, a unique meroterpenoid from the deep-sea-derived Penicillium allii-sativi, significantly inhibited retinoid X receptor (RXR)-α transcriptional effect. Chin. Chem. Lett. 2022, 33, 2057-2059. He, Z. H.; Xie, C. L.; Hao, Y. J.; Xu, L.; Wang, C. F.; Hu, M. Y.; Li, S. J.; Zhong, T. H.; Yang, X. W.* Solitumergosterol A, a unique 6/6/6/6/5 steroid from the deep-sea-derived Penicillium solitum MCCC 3A00215. Org. Biomol. Chem. 2021, 19, 9369-9372. Xie, C. L.; Liu, Q.; He, Z. H.; Gai, Y. B.; Zou, Z. B.; Shao, Z. Z.; Liu, G. M.; Chen, H. F.; Yang, X. W.* Discovery of andrastones from the deep-sea-derived Penicillium allii-sativi MCCC 3A00580 by OSMAC strategy. Bioorg. Chem. 2021, 108, 104671. Xie, C. L.; Zhang, D.; Lin, T.; He, Z. H.; Yan, Q. X.; Cai, Q.; Zhang, X. K.; Yang, X. W.*; Chen, H. F.* Antiproliferative sorbicillinoids from the deep-sea-derived Penicillium allii-sativi. Front. Microbiol. 2021, 11, 636948. He, Z. H.; Wu, J.; Xu, L.; Hu, M. Y.; Xie, M. M.; Hao, Y. J.; Li, S. J.; Shao, Z. Z.; Yang, X. W.* Chemical constituents of the deep-sea-derived Penicillium solitum. Mar. Drugs 2021, 19, 580. Niu, S.; Xie, C. L.; Xia, J. M.; Liu, Q. M.; Peng, G.; Liu, G. M.; Yang, X. W.* Botryotins A–H, tetracyclic diterpenoids representing three carbon skeletons from a deep-sea-derived Botryotinia fuckeliana. Org. Lett. 2020, 22, 580-583. Zou, Z. B.; Zhang, G.; Li, S. M.; He, Z. H.; Yan, Q. X.; Lin, Y. K.; Xie, C. L.; Xia, J. M.; Luo, Z. H.; Luo, L. Z.*; Yang, X. W.* Asperochratides A–J, ten new polyketides from the deep-sea-derived Aspergillus ochraceus. Bioorg. Chem. 2020, 105, 104349. Xie, C. L.; Chen, R.; Yang, S.; Xia, J. M.; Zhang, G. Y.; Chen, C. H.; Zhang, Y.; Yang, X. W.* Nesteretal A, a novel class of cage-like polyketide from marine-derived actinomycete Nesterenkonia halobia. Org. Lett. 2019, 21, 8174-8177. Niu, S.; Xia, J. M.; Li, Z.; Yang, L. H.; Yi, Z. W.; Xie, C. L.; Peng, G.; Luo, Z. H.; Shao, Z.; Yang, X. W.* Aphidicolin chemistry of the deep-sea-derived fungus Botryotinia fuckeliana MCCC 3A00494. J. Nat. Prod. 2019, 82, 2307-2331. Xie, C. L.; Xia, J. M.; Lin, T.; Lin, Y. J.; Lin, Y. K.; Xia, M. L.; Chen, H. F.; Luo, Z. H.; Shao, Z. Z.; Yang, X. W.* Andrastone A from the deep-sea-derived fungus Penicillium allii-sativi acts as an inducer of caspase and RXRα-dependent apoptosis. Front. Chem. 2019, 7, 692.