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个人简介

曹晓华博士,研究员,华东师范大学 脑功能基因组学教育部重点实验室 学习记忆与突触可塑性研究室负责人。中国生理学会理事、中国神经科学学会应激神经生物学分会委员、中国心理学会生理心理专委会委员、《Stress and Brain》编委。2000年在华东师范大学获得博士学位,先后分别在复旦大学、普林斯顿大学和波士顿大学进行博士后研究工作。主要从事认知和情绪神经环路和分子机制,及其障碍(包括阿尔茨海默症、创伤后应激障碍和抑郁等)病理机制的研究。曹晓华博士先后主持国家973、 863子课题、国家重点研发计划和国家自然科学基金面上项目。在高质量的国际专业学术刊物《Nature》、《The New England Journal of Medicine》、《Neuron》(封面文章)、《Cell Research》、《PNAS》、《Cerebral Cortex》、《Current Biology》、《Crit Care Med》、《Neuropharmacology》发表了一系列的研究论文。 教育经历 1997年9月—2000年7月 华东师范大学生物系 博士 工作经历 2005年7月 —至今 华东师范大学脑功能基因组学教育部重点实验室 学习记忆与可塑性研究室负责人 教授 博导 2004年7月—2005年6月 美国波士顿大学医学院药理学系访问研究者 2003年6月—2004年6月 美国普林斯顿大学分子生物学系访问研究者 2001年5月—2003年5月 复旦大学神经生物研究所博士后研究者

研究领域

将分子生物学、离体电生理、在体多通道电生理记录、光遗传学、钙成像和整体行为学等多种方法相结合,从分子、细胞突触、神经环路和整体不同层次,研究认知和情绪的神经环路和分子机制,及其障碍(包括阿尔茨海默症、创伤后应激障碍和抑郁等)的病理机制

近期论文

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Yue Zhou, Yanhong Duan Y,Shichao Huang,Xuan Zhou, Lishuang Zhou, Tingting Hu, Yongfeng Yang, Jing Lu,Kan Ding,Dean Guo,Xiaohua Cao*, Gang Pei*. Polysaccharides from Lycium barbarum ameliorate amyloid pathology and cognitive functions in APP/PS1 transgenic mice. Int J Biol Macromol. 144:1004-1012. 2020 Lu Yu, Zhili Liu, Wendi He, Huifen Chen, Zelin Lai, Yanhong Duan, Xiaohua Cao, Jie Tao, Chuan Xu, Qiujuan Zhang*, Zheng Zhao*, Jun Zhang*. Hydroxysafflor Yellow A Confers Neuroprotection from Focal Cerebral Ischemia by Modulating the Crosstalk Between JAK2/STAT3 and SOCS3 Signaling Pathways. Cellular and Molecular Neurobiology. 40:1271–1281, 2020 Z. Ardi, A. Richter-Levin4, L. Xu, X. cao, H. Volkmer, O. Stork, G. Richter-Levin*. The role of the GABAA receptor Alpha 1 subunit in the ventral hippocampus in stress resilience. 9:13513 | https://doi.org/10.1038/s41598-019-49824-4, 2019. Hailing Shi, Xuliang Zhang, Yi-Lan Weng, Zongyang Lu, Yajing Liu, Zhike Lu, Jianan Li, Piliang Hao, Yu Zhang, Feng Zhang, You Wu, Jary Y. Delgado, Yijing Su, Meera J. Patel, Xiaohua Cao, Bin Shen, Xingxu Huang, Guo-li Ming, Xiaoxi Zhuang, Hongjun Song, Chuan He & Tao Zhou* m6A facilitates hippocampus-dependent learning and memory through YTHDF1. Nature. 563(8): 249-253, 2018 Mou?Xiong Zheng, Xu?Yun Hua,, Jun?Tao Feng, Tie Li, Ye?Chen Lu, Yun?Dong Shen, Xiao?Hua Cao, Nai?Qing Zhao, , Jia?Ying Lyu, Jian?Guang Xu, Yu?Dong Gu, and Wen?Dong Xu*. Trial of Contralateral Seventh Cervical Nerve Transfer for Spastic Arm Paralysis. New England Journal of Medicine. 4; 378(1): 22-34, 2018 Yanhong Duan, Qi Wang , Qingwen Zeng, Jiayue Wang, Zhenzhen Chen, Meichen Xu, Yale Duan, Zheng Zhao, Qingsheng Xue, Xiaohua Cao*. Striatal GluN2B involved in motor skill learning and stimulus response learning. Neuropharmacology, 135: 73-85, 2018 Lu Yu, Yanhong Duan, Zheng Zhao, Wendi He, Ming Xia,Qiujuan Zhang, Xiaohua Cao*Hydroxysafflor Yellow A (HSYA)Improves Learning and Memory in Cerebral Ischemia Reperfusion-Injured Rats via Recovering Synaptic Plasticity in the Hippocampus. Frontiers in Cellular Neuroscience. doi: 10.3389/fncel.2018.00371. 12, 2018 Xuke Han, Huangan Wub, Ping Yin, Zeqin Chen, Xiaohua Cao, Yanhong Duan, Jian Xu, Lixing Lao?, Shifen Xu?Electroacupuncture restores hippocampal synaptic plasticity via modulation of 5-HT receptors in a rat model of depression.Brain Research Bulletin, 139: 256–262, 2018 Qi Wang, Pengcheng Yin, Bin Yu, Zheng Zhao, Gal Richter-Levin, Lu Yu, Xiaohua Cao*.Down-regulation of dorsal striatal αCaMKII causes striatum-related cognitive and synaptic disorders.Experimental Neurology, 298, 112-121, 2017 Pengcheng Yin, Hao Xua, Qi Wang, Jiayue Wang, Liang Yin, Meichen Xu, Zhenyang Xie, Wenzhao Liu, Xiaohua Cao*. Overexpression of βCaMKII impairs behavioral flexibility and NMDAR-dependent long-term depression in the dentate gyrus. Neuropharmacology,116, P 270–287,2017 Jing Ma, Yanhong Duan, Zhenxia Qin, Jiayue Wang, Wenzhao Liu, Meichen Xu, Siqi Zhou, Xiaohua Cao*Overexpression of αCaMKII Impairs Behavioral Flexibility and NMDAR-Dependent LTD in the Medial Prefrontal Cortex. Neuroscience, 310, 528–540, 2015 Yanhong Duan, Siqi Zhou, Jing Ma, Pengcheng Yin, Xiaohua Cao*. Forebrain NR2B overexpression enhancing fear acquisition and long-term potentiation in the lateral amygdala. European Journal of Neuroscience. European Journal of Neuroscience. pp. 1-10, 2015. Yanling She, Jian Xu, Yanhong Duan, Ning Su, Yanan Sun, Xiaohua Cao, Lixing Lao, Ruixin Zhang, Shifen Xu. Possible antidepressant effects and mechanism of electroacupuncture in behaviors and hippocampal synaptic plasticity in a depression rat model. Brain Research.1629:291-297.2015 Hong Wei #, Xiaohua Cao#, Qinwen Zeng, Zhang F, Xue Q, Luo Y, Lee JW, Yu B, Feng X. Ghrelin inhibits proinflammatory responses and prevents cognitive impairment in septic rats. Crit Care Med. 43(5):e143-50. doi: 10.1097/CCM.0000000000000930, 2015 Xin Guan, Yanhong Duan, Qingwen Zeng, Hongjie Pan, Yu Qian, Dali Li*, Xiaohua Cao*, Mingyao Liu*. Lgr4 Protein Deficiency Induces Ataxia-like Phenotype in Mice and Impairs Long Term Depression at Cerebellar Parallel Fiber-Purkinje Cell Synapses.J Biol Chem. 289(38):26492-504, 2014 Zhang, Fujun, Feng, Xiaomei,Zeng, Qingwen,Wang, Bo,Wilhelmsen, Kevin,Li, Qiang, Cao, Xiaohua, Yu, Buwei. Sevoflurane induced amnesia inhibits hippocampal Arc expression partially through 5-hydroxytryptamine-7 receptors in the bilateral basolateral amygdala in rats .Neuroscience Letters.562:13-18. 2014 Xuliang Zhang, Bo Wang, Jing Jin , Shuming An, Qingwen Zeng, Yanhong Duan,Liguo Yang, Jing Ma, Xiaohua Cao* Early deprivation reduced anxiety and enhanced memory in adult male rats. Brain Research Bulletin.108, 44–50, 2014 Zhenzhong Cui, Ruiben Feng, Stephanie Jacobs, Yanhong Duan, Huimin Wang, Xiaohua Cao, Joe Z. Tsien, Increased NR2A:NR2B ratio compresses long-term depression range and constrains long-term memory. Sci. Rep. 3, 1036; DOI:10.1038/ srep01036, 2013. Suzhen Dong, Qingwen Zeng, E. Siobhan Mitchell, Jin Xiu, Yale Duan, Chunxia Li, Jyoti K. Tiwari, Yinghe Hu, Xiaohua Cao*, Zheng Zhao. Curcumin Enhances Neurogenesis and Cognition in Aged Rats: Implications for Transcriptional Interactions Related to Growth and Synaptic Plasticity. PLoS ONE. 7(2): e31211. 2012 Qingwen Zeng, Jiao Han Bo Wang, Shuming An, Yanhong Duan, Suzhen Dong, Jin Ma, L Yang, Xiaohua Cao*. Water Maze Spatial Learning Enhances Social Recognition Ability in Aged Rats. Neurophysiology, 44(6), pp 464-469, 2012 Zhiliang Xu, Suzhen Dong, Dan Du, Nan Jiang, Peiqua Sun, HuikunWang, Liang Yin, Xuliang Zhang, Xiaohua Cao, Xuechu Zhen, Yinghe Hu. Generation and Characterization of hD5 and C-terminal Mutant hD5m Transgenic Rats. Brain Research.S0006-8993(12):00199-0.2012 Yihui Cui, Jing Jin, Xuliang Zhang, Hao Xu, Liguo Yang, Dan Du, Qingwen Zeng, Joe Z. Tsien. Xiaohua Cao* Forebrain NR2B Overexpression Facilitating the Prefrontal Cortex Long-term Potentiation and Enhancing Working Memory Function in Mice. PLoS ONE. 6(5), e20312, 2011 Hong-Yuan Chu, Qianqian Wu, Shanglin Zhou, Xiaohua Cao, Ao Zhang, Guo-Zhang Jin, Guo-Yuan Hu, Xuechu Zhen. SKF83959 suppresses excitatory synaptic transmission in rat hippocampus via a dopamine receptor-independent mechanism. J Neurosci Res, 2011. Qiang Li, Xuesheng Liu, Qingwen Zeng, Qingsheng Xue, Xiaohua Cao, Jian Liu,Yu Ren,Buwei Yu. Post-training intra-basolateral amygdala infusions of norepinephrine block sevo?urane-induced impairment of memory consolidation and activity-regulated cytoskeletal protein expression inhibition in rat hippocampus. Neurobiology of Learning and Memory. 96 (3): 492-497. 2011 Dong Wang, Liguo Yang, Jingjing Su, Yan Niu, Xiaoping Lei, Juan Xiong, Xiaohua Cao, Yinghe Hu, Bing Mei, Jin-Feng Hu. Attenuation of neurodegenerative phenotypes in Alzheimer-like presenilin1/presenilin 2 conditional double knockout mice by EUK1001, a promisingderivative of xanomeline. Biochemical and Biophysical Research Communications. 410:229-234.July 2011 Jing Zheng, Da-Feng Xu, Kui Li, Hong-Tao Wang, Peng-Cheng Shen, Min Lin, Xiao-Hua Cao, Rui Wang. Neonatal exposure to fluoxetine and fluvoxamine alteres spine density in mouse hippocampal CA1 pyramidal neurons. International Journal of Clinical and Experimental Pathology. 4(2), pp 162-168, 2011 Wen Si, Xuliang Zhang, Niu Y, Lei XP, Yu HT, Chen HX, Xiaohua Cao*. A novel derivative of xanomeline improves fear memory in aged mice. Neurosci Lett. 2010.473: 115-119 Deheng Wang., Zhenzhong Cui, Qingwen Zeng, Hui Kuang, L. Phillip Wang, Joe Z. Tsien*, Xiaohua Cao* Genetic Enhancement of Memory and Long-Term Potentiation but Not CA1 Long-Term Depression in NR2B Transgenic Rats. PLoS ONE. 4 (10), e7486, 2009 Yuanyuan Zhang, Fei Li, Xiaohua Cao, Xingming Jin, Chonghuai Yan,Ying Tian, and Xiaoming Shen. Forepaw Sensorimotor Deprivation in Early Life Leads to the Impairments on SpatialMemory and Synaptic Plasticity in Rats. Journal of Biomedicine and Biotechnology, Article ID 919276, 9 pages doi:10.1155/2009/919276, 2009 Hong Cao, Yong-Jing Gao, Wen-Hua Ren, Ting-Ting Li, Kai-Zheng Duan, Yi-Hui Cui, Xiao-Hua Cao, Zhi-Qi Zhao, Ru-Rong Ji, and Yu-Qiu Zhang. Activation of Extracellular Signal-Regulated Kinase in the Anterior Cingulate Cortex Contributes to the Induction and Expression of Affective Pain. J Neurosci, 29 (10):3307-3321, 2009. Yihui Cui, Dong Wang, Wen Si, Wen Lv, Yan Niu, Xiaoping Lei, Yinhe Hu, Xiaohua Cao* Enhancement of memory function in aged mice by a novel derivative of xanomeline. Cell Research. 18:1151-1153, 2008. Xiaohua Cao#, Huimin Wang#, Bing Mei#, Shuming An, Liang Yin, Phillip L. Wang, and Joe Z. Tsien. Inducible and Selective Erasure of Memories in the Mouse Brain via Chemical-Genetic Manipulation. Neuron 60, 353-36, 2008. (Cover story) Huimin Wang, Ruiben Feng, Fei Li, Xiaohua Cao, & Joe Z. Tsien. CaMKII Activation State Underlies Synaptic Labile phase of LTP and Short-Term Memory Formation. Current Biology18, 1546-1554, 2008. Yi-Hui Cui, Wen Si, Liang Yin, Shu-Ming An, Jing Jin, Shi-Ning Deng, Xiao-Hua CAO* A novel derivative of xanomeline improved memory function in aged mice. Neurosci Bull. 2008 24(4): 251-257. Ai LI, Wen SI, Xin-Wu HU, Chang-Jing LIU, Xiao-Hua CAO* An optimized recording method to characterize biophysical and pharmacological properties of acid-sensing ion channel. Neurosci Bull. 2008 24(3):160-165. Xiao-Hua Cao*, Deheng Wang, Jin Bai, Shaoci Zhou, Yongdi Zhou Prefrontal modulation of tactile responses in the ventrobasal thalamus of rats. Neuroscience letters. 435, 152–157. 2008 Xiao-Hua Ji#, Xiao-Hua Cao#, Chun-Lei Zhang, Ze-Jun Feng, Xue-Han Zhang, Lan Ma and Bao-Ming Li. Pre- and post-synaptic β--adrenergic activation enhances excitatory synaptic transmission in layer V/VI pyramidal neurons of the medial prefrontal cortex of rats. Cereb. Cortex, 2008, 18: 1506-1520.( #Co-first author) Min H. Cho, Xiaohua Cao, Deheng Wang, Joe Z. Tsien. Dentate gyrus-specific manipulation of {beta}-Ca2+/calmodulin-dependent kinase II disrupts memory consolidation. Proc Natl Acad Sci U S A. Vol. 104(41), 16317-22. 2007. Xiaohua Cao*, Zhenzhong Cui, Ruiben Feng, Ya-Ping Tang, Zhenxia Qin, Bing Mei and Joe Z. Tsien. Maintenance of superior learning and memory function in NR2B transgenic mice during ageing. European Journal of Neuroscience, Vol.25, pp. 1815-1822, 2007 Jing Bai, Deheng Wang, Liang Yin, Shuming An, Shaoci Zhou,XiaohuaCao*. Properties of tactile responses of neurons in rat thalamic ventroposterolateral nucleus. Neurosci Bull. 23(5):300-6. 2007 Liu Xinqiu, Cao Xiaohua & Li Baoming. β- Adrenergic activation enhances NMDA-induced currents in pyramidal cells of the basolateral nucleus of amygdala. Chinese Science Bulletin Vol. 50(17)1923-1925, 2005. Yen Wei, Houping Yin, Xiaohua Cao Patrick Ndungu, Jean-Claude Bradley, Guoliang Yang, Kambiz Pourrezaei, Peter Lelkes, Joe Tsien .Nanoelectrodes Fabricated from Electron Beam Deposited Carbon as Potential Electrochemical neuronal Probes. Journal of Biomedical Nanotechnology, Vol. 1 (No.3, September), pp. 336-340, 2005. He Defu, Feng maozi, Xiaohua Cao, Zhou Shaoci. “Relationship between amygdala and emotion” Psychological Science, 24 (5): 80-84, 2001. Cao Xiaohua, Lu Xiangyue & Zhou Shaoci. “The facilitatory influence of anterior cingulate cortex on ON-OFF response of tactile neuron in thalamic ventrobasal nucleus”. Science in China (Series C) 2000, 43(5): 544-552 Hao Xu, Bo Wang, Yanhong Duan, Xiaohua Cao*. βCaMKⅡ overexpression impairs long term depression in dentate gyrus of mice. Journal of East China Normal University, 2012 (1): 54-62. Liguo Yang, Qingwen Zeng, Xuliang Zhang, Xiaohua Cao*. Long term potentiation of prefrontal cortex in NR1 knockout mice. Journal of East China Normal University, 20121 (1): 47-52. Jing Jin, Xuliang Zhang, Liguo Yang, Hao Xu, Qingwen Zeng, Xiaohua Cao*. Early maternal deprivation impairs emotional memory in rats. Journal of East China Normal University, 2011 (2): 163-170. Ruqing Liu, Yanhong Duan, Xiaohua Cao*. αCaMKII overexpressions enhance excitatory synaptic transmission in insular cortex of mice. Journal of East China Normal University, 2011 (4): 94-103. Shuming An, Qingwen Zeng, Hao Xu, Ruqing Liu, Xiaohua Cao*. Forebrain expression of αCaMKII disrupts behavioral flexibility. Journal of East China Normal University, 2010 (2): 111-118. Liang Yin, Qingwen Zeng, Dan Du, Xiaohua Cao*. Study of βCaMKII on working memory in protein modified transgenic mice. Journal of East China Normal University, 2010 (2): 119-126. Shining Deng, Wen Si, Lijuan Sun, Qingwen Zeng, Xiaohua Cao*. Experiment-time affects the cognitive behavior in aged Sprague-Dawley rats. Acta Physiologica Sinica, 2010, 62 (3): 231-236. Wen Si, Jin Bai, Shining Deng, Qingwen Zeng, Xiaohua Cao*. Enhance effect of magnesium on learning and memory ability in aged mice. Journal of East China Normal University, 2011 (6): 96-103. Jinjin Xue, Qiang Li, Qingwen Zeng, Qingsheng Xue, Xiaohua Cao, Fujun Zhang. Buwei Yu. Glucocorticoid reverses the impairment of memory consolidation mediated by sevoflurane. Shanghai Medical Journal, 2013 (2): 126-130. Yuanyuan Zhang, Fei Li, Xingming Jin, Chonghuai Yan, Ying Tian, Xiaohua Cao, Xiaoming Shen. Early life forepaw sensorimotor deprivation impairs the synaptic plasticity at the Schaffer-CA1 synapse in hippocampus of young rats. Chinese Journal of Child Health Care, 2010 (1): 45-48.

学术兼职

中国生理学会理事 中国生理学会应激生理专业委员会委员 中国神经科学学会学习记忆基础与临床分会和应激神经生物学分会委员 中国心理学会生理心理专委会委员 《Brain & Stress》编委

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