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个人简介

俞磊教授现为华东师范大学紫江学者,生物医学工程与技术研究所所长,美国犹他大学化学制药与制药系和生物工程系客座副教授。主要研究方向为靶向药物传递系统、基因治疗和细胞治疗领域。早期在被誉为世界基因治疗之父的TheodoreFriedman指导下,进行病毒载体用于遗传疾病、癌症、心血管疾病、神经性病变、传染性疾病的基因治疗和细胞治疗中转基因技术的研究。随后在被世界生物高分子药物载体先驱Sun WangKim课题组工作,并成功申请到美国NIH的基金资助。2004在美国成立公司继续进行肿瘤靶向治疗和细胞免疫治疗技术的临床转化和产品开发。2012年全职回国加入华东师范大学,与全国著名的血液科开展多中心临床实验合作,目前已开展了200多例CAR-T治疗血液肿瘤临床案例研究,在难治复发急性B淋巴细胞白血病的治疗中取得了86%以上完全缓解的疗效。近年来在Theranostics,Journal of Controlled Release,Bioconjugate Chemistry,Molecular Pharmaceutics等杂志发表SCI论文30余篇。

研究领域

新型智能药物传递系统,重点研究针对肿瘤、肝纤维化、肝硬化等疾病的靶向和环境响应递药系统 基因治疗,重点研究siRNA、shRNA的体内靶向递送 细胞免疫治疗,重点研究嵌合抗原受体T细胞(CAR-T)对白血病和淋巴瘤等疾病的治疗

近期论文

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Jia Z#, Gong Y#, Pi Y, Liu X, Gao L,Kang L, Wang J, Yang F, Tang J, Lu W, Li Q, Zhang W, Yan Z*, Yu L*. pPB Peptide-MediatedsiRNA-Loaded Stable Nucleic Acid Lipid Nanoparticles on Targeting Therapy ofHepatic Fibrosis. Mol Pharm, 2018, 15(1): 53-62. Gao L, Yu J, Liu Y, Zhou J, Sun L, Wang J, Zhu J, Peng H, LuW, Yu L, Yan Z*, Wang Y*. Tumor-penetrating Peptide Conjugated and DoxorubicinLoaded T1-T2 Dual Mode MRI Contrast Agents Nanoparticles for TumorTheranostics[J]. Theranostics, 2018, 7(20):4984-5000. Yu J#, Sun L#, Zhou J, Gao L, Nan L,Zhao S, Peng T, Han L, Wang J, Lu W, Zhang L, Wang Y, Yan Z*, Yu L*. Self-Assembled Tumor PenetratingPeptide Modified Poly (L-gamma-glutamylglutamine)-Paclitaxel NanoparticlesBased on Hydrophobic Interaction for Treatment of Glioblastoma. Bioconjug Chem,2017, 28(11):2823-2831 Gao L, Wang H, Nan L, Peng T, Sun L, Zhou J, Xiao Y, Wang J,Sun J, Lu W, Zhang L, Yan Z*, Yu L, Wang Y*. Erythrocyte Membrane-Wrapped pHSensitive Polymeric Nanoparticles for Non-Small Cell Lung Cancer Therapy[J].Bioconjug Chem, 2017, 28(10):2591-2598 Luo Z, Yan Z, Jin K, Pang Q, Jiang T, Lu H, Liu X, Pang Z*, Yu L*, Jiang X. Precise glioblastomatargeting by AS1411 aptamer-functionalized poly (l-gamma-glutamylglutamine)-paclitaxelnanoconjugates. J Colloid Interface Sci, 2017, 490: 783-796. Luo Z, Jin K, Pang Q, Shen S, Yan Z, Jiang T, Zhu X, Yu L*, Pang Z*, Jiang X. On-Demand DrugRelease from Dual-Targeting Small Nanoparticles Triggered by High-IntensityFocused Ultrasound Enhanced Glioblastoma-Targeting Therapy. ACS Appl MaterInterfaces, 2017, 9(37): 31612-31625. Fan M, Li M, Gao L, Geng S, Wang J, Wang Y, Yan Z*, Yu L*. Chimeric antigen receptors foradoptive T cell therapy in acute myeloid leukaemia. J Hematol Oncol, 2017,10(1): 151. Zhou JE#, Yu J#, Gao L, Sun L, Peng T,Wang J, Zhu J, Lu W, Zhang L, Yan Z*, YuL*. iNGR-Modified Liposomes for Tumor Vascular Targeting and Tumor TissuePenetrating Delivery in the Treatment of Glioblastoma. Mol Pharm, 2017, 14(5):1811-1820. Gao L, Han L, Ding X, Xu J, Wang J, Zhu J, Lu W, Sun J, Yu L,Yan Z*, Wang, Y*. An Effective Intracellular Delivery System of MonoclonalAntibody for Treatment of Tumor: Erythrocyte Membrane-coated Self-associatedAntibody Nanoparticles[J]. Nanotechnology, 2017, 28(33):335101. Gao L, Gao L, Fan M, Li Q, Jin J, Wang J, Lu W, Yu L, Yan Z*,Wang Y*. Hydrotropic polymer-based paclitaxel-loaded self-assemblednanoparticles: preparation and biological evaluation[J]. Rsc Advances, 2017,7(53): 33248-33256. Gao L, Zhou J, Yu J, Li Q, Liu X, Sun L, Peng T, Wang J, ZhuJ, Sun J*, Lu W, Yu L, Yan Z*, Wang Y*. A Novel Gd-DTPA-conjugatedPoly(L-gamma-glutamyl-glutamine)-paclitaxel Polymeric Delivery System for TumorTheranostics[J]. Sci Rep, 2017, 7(1): 3799. T Peng, K Liu, L Gao, J Chen, J Wang, Y Liu, Y Wang, Z Yan*,L Yu*, Poly (l-γ-glutamylglutamine) Polymer Enhances Doxorubicin Accumulationin Multidrug Resistant Breast Cancer Cells, Molecules, 2016, 21(6): E720 Y. Pi, J. Zhou, J. Wang, J. Zhong, L. Zhang, Y. Wang, L. Yu*,Z. Yan*, Strategies of Overcoming the Physiological Barriers for Tumor-TargetedNano-Sized Drug Delivery Systems, Curr Pharm Des, 2015, 21(42): 6236-45 Yanjie Bao, Yi Jin, Padmanabh Chivukula,Jun Zhang, Yun Liu, Jian Liu, Jean-Pierre Clamme, Ram I. Mahato, Dominic Ng,Wenbin Ying, Yiting Wang, and Lei Yu*. Effect of PEGylation on Biodistribution and GeneSilencing of siRNA/Lipid Nanoparticle Complexes. Pharmaceutical Research, 2013,30(2):342-51 Yang D, Liu X, Jiang X, Liu Y, Ying W,Wang H, Bai H, Taylor WD, Wang Y, Clamme JP, Co E, Chivukula P, TsangKY, Jin Y,Yu L*. Effect of molecular weight of PGG-paclitaxel conjugateson in vitro and in vivo efficacy. J Control Release. 2012, 161(1):124-31 Yang D, Van S, Shu Y, Liu X, Ge Y, JiangX, Jin Y, Yu L*. Synthesis, characterization, and in vivo efficacyevaluation of PGG-docetaxel conjugate for potential cancer chemotherapy. Int JNanomedicine, 2012, 7:581-9 Liu C, Zhao G, Liu J, Ma N, Chivukula P,Perelman L, Okada K, Chen Z, Gough D, YuL*. Novel biodegradable lipid nano complexfor siRNA delivery significantly improving the chemosensitivity of human coloncancer stem cells to paclitaxel. J Control Release, 2009, 140(3):277-83

学术兼职

美国犹他大学化学制药与制药系和生物工程系客座副教授 复旦大学教育部及全军智能化递药重点实验室客座教授 上海市药学会药剂专委会委员

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