陈大伟 - 中国医学科学院药物研究所 -

个人简介

2016年毕业于北京协和医学院，获医学博士学位。2018年获“北京协和医学院优秀博士论文”、“梁周黄于刘”青年科技奖-三等奖；2016年获“北京市优秀毕业生”；2015年获“中国药学会优秀论文”一等奖和“北京药学年会-研究生论文报告”一等奖；2015年和2012年分别获博士、硕士研究生国家奖学金。以第一作者/通讯作者发表SCI论文14篇，IF>10的论文3篇。申请中国发明专利6项；主持国家级科研项目2项。作为学术骨干参与新药创制国家重大科技专项等多项国家级科研项目及科技部创新人才推进计划重点领域“药用天然产物合成生物学创新团队”

研究领域

(1) 药用天然产物生物合成与酶法催化; (2) 新颖酶挖掘、定向改造及催化机制研究; (3) 新颖活性化合物发现与生物合成.

近期论文

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Yangyang Duan, Wenyu Du, Zhijun Song, Ridao Chen, Kebo Xie, Jimei Liu, Dawei Chen*, Jungui Dai*. Functional characterization of a cycloartenol synthase and four glycosyltransferases in the biosynthesis of cycloastragenol-type astragalosides from Astragalus membranaceus. Acta Pharmaceutica Sinica B, 2023, 13, 271–283. IF: 14.5 Dawei Chen, Shuai Fan, Ridao Chen, Kebo Xie, Sen Yin, Lili Sun, Jimei Liu, Lin Yang, Jianqiang Kong, Zhaoyong Yang, and Jungui Dai*. Probing and engineering key residues for bis-C-glycosylation and promiscuity of a C-glycosyltransferase. ACS Catalysis, 2018, 8, 4917–4927. IF: 12.221 Dawei Chen, Ridao Chen, Ruishan Wang, Jianhua Li, Kebo Xie, Chuancai Bian, Lili Sun, Xiaolin Zhang, Jimei Liu, Lin Yang, Fei Ye, Xiaoming Yu, Jungui Dai*. Probing the catalytic promiscuity of a regio- and stereospecific C-glycosyltransferase from Mangifera indica. Angewandte Chemie International Edition, 2015, 54, 12678–12682. IF: 11.709 Dawei Chen, Ridao Chen, Kebo Xie, Tian Yue, Xiaolin Zhang, Fei Ye, and Jungui Dai*. Biocatalytic C-glucosylation of coumarins using an engineered C-glycosyltransferase. Organic Letters, 2018, 20, 1634–1637. IF: 6.555 Dawei Chen*, Shuai Fan, Zhaoyong Yang, and Jungui Dai*. Biocatalytic application of a membrane-bound coumarin C-glucosyltransferase in the synthesis of coumarin and benzofuran C-glucosides. Advanced Synthesis & Catalysis, 2021, 363, 5072–5078. IF: 5.981