个人简介
在炎症性肠病（IBD）免疫病理学发病机制方面做出了突出成绩，发现炎症肠黏膜组织内有大量激活的免疫细胞浸润，分泌高水平的炎症细胞因子，以及表达高水平免疫辅助信号分子。尤其是通过调控肠黏膜组织内各种免疫细胞（T细胞、巨噬细胞、中性粒细胞等）的功能变化，为临床上靶向生物免疫治疗IBD提供重要的理论依据；使用抗TNF、IL-12、IL-23、a4b7单抗，以及小分子阻断剂和miRNA片段治疗，发现可显著诱导肠黏膜炎症发生。在Gastroenterology、Gut、J Allergy Clin Immunol、Nat Commun等国际期刊发表SCI论文100余篇，多次在美国胃肠病学大会和欧洲胃肠病联合大会上报告论文，在国际上有较高学术影响。
主要任职
第十届中华医学会消化病分会炎症性肠病学组副组长
中国医师学会肛肠医师分会炎症性肠病学组副组长
中华医学会上海市消化学分会委员，兼炎症性肠病学组组长
世界华人消化杂志-主编; 中华炎性肠病杂志、J Dig Dis副主编
近期论文
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MicroRNA-31 reduces inflammatory signaling and promotes regeneration in colon epithelium, and delivery of mimics in microsperes reduces colitis in mice. Gastroenterology, 2019;156(8):2281-96.
ATF4 deficiency promotes intestinal inflammation in mice by reducing uptake of glutamine and expression of antimicrobial peptides. Gastroenterology, 2019;156(4): 1098-1111.
Microbiota metabolites short-chain fatty acids promote Th1 cell IL-10 production to maintain intestinal homeostasis. Nat Commun, 2018;9(1):3555.
TRIM21 negatively regulates intestinal mucosal inflammation through inhibiting Th1/Th17 cell immune responses in inflammatory bowel disease. J Allergy Clin Immunol, 2018;142(4): 1218-28.
CD177+ neutrophils as functionally activated neutrophils negatively regulate inflammatory bowel disease. Gut, 2018;67(6):1052-63.
MicroRNA-301A promotes intestinal inflammation and colitis-associated cancer development by inhibiting BTG1. Gastroenterology, 2017;152(6):1434-1448.
miR-301a promotes intestinal mucosal inflammation through induction of IL-17A and TNF-a in inflammatory bowel disease. Gut, 2016;65(12):1938-1950.
miR-10a inhibits dendritic cell activation and Th1/Th17 cell immune responses in IBD. Gut, 2015;64(11):1755-1764.
Prolactin mediates psychological stress-induced dysfunction of regulatory T cells to facilitate intestinal inflammation. Gut 2014;63(12):1883-92.
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