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主持国家及省部级项目在内的基金项目共10项,获得5项实用新型专利(其中3项排名第1)申请1项发明专利,以第一和通信作者发表SCI论文25篇(总影响因子121.07分,单篇最高9.162分)。 主要基金及科研项目 国家自然科学基金面上项目,81972409,促增殖蛋白MS4A8B通过Exosome介导前列腺癌骨转移的机制研究,2020.01-2023.12,54万,在研,主持 国家自然科学基金面上项目,81672549,促前列腺癌增殖蛋白MS4A8B调节钙池操纵的钙通道(SOC)的分子机制及其靶向性单克隆抗体相关研究,2017.01-2020.12,57万,已结题,在研 国家自然科学基金面上项目,81472389,跨膜蛋白MS4A8B在前列腺癌癌变过程中的功能及分子机制,2015.01-2018.12,72万,已结题,参加(排名第2) 上海市自然科学基金面上项目,15ZR1433000,SCIN在前列腺癌中的功能及分子机制研究,2015.01-2017.12,10万,已结题,主持 中国博士后科学基金第53批面上资助,2013M531123,MS4A8B与前列腺癌的转移和进展相关的机制研究,2013.06-2014.05,5万, 已结题,主持 上海市博士后科研资助计划面上项目(A类),12R21411600,TAZ的表达和调控与雄激素非依赖性前列腺癌发生机制的研究,2012.06-2013.05,4万,已结题,主持 大连市科技计划项目,2004B3SF163,前列腺癌组织细胞凋亡与Survivin基因表达的研究,2004.06-2007.05,3万,已结题,主持

研究领域

前列腺癌和上尿路尿路上皮肿瘤的基础与临床研究

近期论文

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Mei W, Jin L, Zhang B, Sun X, Liu X, Xin S, Zhang J, Yang G, Li S*, Ye L*. A Moonlighting Gene Signature for Prognosis and Immune Microenvironment Estimation in Prostate Cancer. Frontier in Oncology. 2022.9.8 Accept. (JCR Q2, IF5.738)(通讯作者) Jin L†, Mei W†, Liu X, Sun X, Xin S, Zhou Z, Zhang J, Zhang B, Chen P*,Cai M*, Ye L*. Identification of cuproptosis -related subtypes, the development of a prognosis model, and characterization of tumor microenvironment infiltration in prostate cancer. Frontiers in Immunology 2022,13:974034.doi: 10.3389/fimmu.2022.974034.(JCR Q1, IF8.786)(通讯作者) Liu X, Mei W, Jin L, Sun X, Xin S, Huang L, Yang G, Wang J*,Ye L*. Ubiquitin-related lncRNAs: the new tool for prognosis prediction in prostate cancer. Frontiers in Oncology 2022,12:948113. doi: 10.3389/fonc.2022.948113. (JCR Q2, IF5.738)(通讯作者) Mei W†, Liu X†, Jia X, Jin L, Xin S, Sun X, Zhang J, Zhang B, Chen Y, Che J, Ma W*, Ye L*. A Cuproptosis-Related Gene Model for Predicting the Prognosis of Clear Cell Renal Cell Carcinoma. Frontier in Genetics 2022,13:905518.doi: 10.3389/fgene.2022.905518.(JCR Q1, IF4.772)(通讯作者) Sun X #, Xin S#, Zhang Y, Jin L, Liu X, Zhang J, Mei W, Zhang B, Ma W*,Ye L*. The long non-coding RNA CASC11 promotes prostate cancer progression via YBX1-mediated suppression of p53 pathway. International Journal of Oncology. 2022 Sep;61(3):110. doi: 10.3892/ijo.2022.5400. Epub 2022 Jul 29.(JCR Q2, IF5.884)(通讯作者) Sun X, Xin S, Li W, Zhang Y*, Ye L*. Discovery of Notch Pathway-Related Genes for Predicting Prognosisand Tumor Microenvironment Status in Bladder Cancer. Frontier in Genetics, 2022 Jun 30;13:928778. doi: 10.3389/fgene.2022.928778. eCollection 2022.(JCR Q1, IF4.772)(通讯作者) Mei W#, Jia X#, Xin S, Liu X, Jin L, Sun X, Zhang J, Zhang B, Yang G, Chen P*, Ye L*. A N7-Methylguanine-Related Gene Model for Predicting the Prognosis of Prostate Cancer. Journal of Oncology.2022 May 13;2022:8604216. doi: 10.1155/2022/8604216. eCollection 2022. (JCR Q2, IF4.501)(通讯作者) Xin S#, Sun X#, Jin L, Li W, Liu X, Zhou L*, Ye L*. The prognostic signature and therapeutic value of phagocytic regulatory factors in Prostate Adenocarcinoma(PRAD). Frontiers in Genetics. 30 May 2022 | https://doi.org/10.3389/fgene.2022.877278 (JCR Q1, IF4.772)(通讯作者) Sun X#, Zhang Y#, Chen Y#, Xin S, Jin L, Liu X, Zhou Z, Zhang J, Mei W, Zhang B, Yao X*, Yang G*, Ye L*. In silico establishment and validation of novel lipid metabolism related gene signature in bladder cancer. Oxidative Medicine and Cellular Longevity. 2022 Apr 18;2022:3170950. doi: 10.1155/2022/3170950. eCollection 2022. (JCR Q2, IF7.31)(通讯作者) Xin S, Sun X, Jin L, Zhou Z, Liu X, Li W, Mei W, Zhang J, Zhang B, Yao X, Zhou L*, Ye L*, Identifying the Potential Role and Prognostic Value of the Platelet-Derived Growth Factor Pathway in Kidney Renal Clear Cell Carcinoma, Journal of Oncology. vol. 2022, Article ID 9498010, 20 pages, 2022. https://doi.org/10.1155/2022/9498010 (JCR Q2, IF4.501)(通讯作者) Zhou Z#, Shi H-J#, Jin L, Liu X, Zhai T-S, Zhang J-X, Ye L*. Prognostic Significance in Patients with Stage III–IV Upper tract urothelial carcinoma According to Age, Sex, Race, and Socioeconomic Status. Actas Urologicas Espanolas.2022.3.11.In Press.(JCR Q4, IF 0.994)(通讯作者) Sun X#, Zhou Z#, Zhang Y, Wang J, Zhao X, Jin L, Zhai T, Liu X, Zhang J, Mei W, Zhang B, Luo M*, Yao X*, Ye L*. Identification and validation of a hypoxia-related prognostic and immune microenvironment signature in bladder cancer. Cancer Cell International. 2021 May 7;21(1):251. doi: 10.1186/s12935-021-01954-4. (JCR Q2, IF 6.429) (通讯作者) Zhou Z#, Yue F#, Jin L#, Liu X, Zhai T-S, Zhang J-X, Gu W-Y, Liu S-H, Luo M, Peng B, Yao X-D, Ye L*. Characteristics and risk differences of different tumor size on localised prostate cancer: A retrospective cohort study in the SEER database. Cancer Medicine. 2021 Apr;10(8):2763-2773. doi: 10.1002/cam4.3856. Epub 2021 Mar 16. (JCR Q2, IF4.711) (通讯作者) Zhai T-S, Hu L-T, Ma W-G, Chen X, Luo M, Jin L, Zhou Z, Liu X, Kang Y, Kang Y-X, Zhang J-X, Liu H, Lu J-Y*, Yao X-D*, Ye L*. Peri-prostatic fat measurements using MRI predict prostate cancer aggressiveness in men undergoing radical prostatectomy. Journal of Endocrinological Investigation. 2021 Feb;44(2):287-296. doi: 10.1007/s40618-020-01294-6. Epub 2020 May 30. (JCR Q2, IF5.467)(通讯作者) Yu Y#, Yang F-H#, Zhang W-T, Guo Y-D, Ye L*, Yao X-D*. Mesenchymal stem cells desensitize castration-resistant prostate cancer to docetaxel chemotherapy via inducing TGF-β1-mediated cell autophagy. Cell And Bioscience. 2021 Jan 7;11(7). doi: 10.1186/s13578-020-00494-0.( JCR Q1, IF 9.584)(共同通讯作者) Liu M#, Zhai T-S#, Feng L-J, lyu X-S, Hu L-T, Wang Z-X, Ma W-G, Zhan J, Zhao X-F, Chen X, Su B-J, Yao X-D, Lu J-Y, Ye L*. Incidental para-ureteral aggressive angiomyxoma: A rare case report and review of the literature. BMC Urology. 2020 Nov 10;20(1):182. doi: 10.1186/s12894-020-00755-7. (JCR Q3, IF2.09)(通讯作者) Zhai T-S#, Jin L#, Feng L-M#, Zhou Z, Liu X, Liu H, Ma W-G, Lu J-Y, Chen W, Yao X-D*, Ye L*. Perioperative chemotherapy on survival in patients with upper urinary tract urothelial carcinoma undergoing nephroureterectomy: A Population-Based Study. Frontiers in Oncology. 2020 Apr 10:481. doi: 10.3389/fonc.2020.00481. eCollection 2020. (JCR Q2, IF5.738)(通讯作者) Zhai, T-S#, Jin L#, Hu L-T#, Kadier A, Zhou Z, Liu X, Liu H, Li S, Lu J-Y, Yao X-D*, Ye L*. Impact of peri-prostatic fat measurements using MRI on the prediction of prostate cancer with transrectal ultrasound-guided biopsy. Urologic Oncology-Seminars and Original Investigations. 2020 Feb;38(2):37.e1-37.e9. (JCR Q2, IF2.954)(通讯作者) Zhai, T-S#, Jin L#, Zhou Z, Liu X, Liu H, Chen W, Lu J-Y, Yao X-D*, Feng L-M*, Ye L*. Effect of lymph node dissection on stage-specific survival in patients with upper urinary tract urothelial carcinoma. BMC Cancer. 2019 Dec 12;19(1):1207. doi: 10.1186/s12885-019-6364-z.(JCR Q2, IF4.430)(通讯作者) Guo Y#, Shi D#, Mao S, Zhang J, Wang L, Zhang W, Zhang Z, Jin L, Yang B, Ye L*, Yao X*. The Hemoglobin, Albumin, Lymphocyte, and Platelet (HALP) Score is a Novel Significant Prognostic Factor for Patients with Metastatic Prostate Cancer Undergoing Cytoreductive Radical Prostatectomy. Journal of Cancer. 2019 Jan 1;10(1):81-91.(JCR Q2, IF4.207)(共同通讯作者) Ye L#, Yao X-D#, Wan F-N#, Qu Y-Y, Liu Z-Y, Yue F, Shen X-X, Li S, Wang N, Liu X-J, Dai B, Ye D-W*. MS4A8B promotes cell proliferation in prostate cancer. The Prostate. 2014;74(9):911-922. (JCR Q2, IF4.104)(第一作者) Ye L#, Li S#, Ye D*, Yang D, Yue F, Guo Y, Chen X, Chen F, Zhang J*, Song X*. Livin expression may be regulated by miR-198 in human prostate cancer cell lines. European Journal of Cancer. 2013, 49(3):734-740. (JCR Q1, IF9.162)(第一作者) Ye L, Zhao L, Yue F, Song X, Wei W, Jiang X, Yang J*. A large ureteral fibroepithelial polyp lacking epithelium due to ischemic infarction---case report and literature review. Kaohsiung Journal of Medical Sciences. 2012, 28(8):457-61.(JCR Q3, IF 2.744)(第一作者) Ye L, Song X*, Li S, Yang D, Zhang J, Che X, Chen X, Wang J, Zhang Z. Livin-alpha promotes cell proliferation by regulating G1-S cell cycle transition in prostate cancer. The Prostate. 2011, 71(1):42-51.( JCR Q2, IF4.104)(第一作者) Qin X#, Ye L#, Zhang H, Dai B, Zhu Y, Shi G, Ye D*. Complicated variation of simple renal cyst usually means malignancy: results from a cohort study. World Journal of Surgical Oncology. 2014 Oct 15;12:316. doi: 10.1186/1477-7819-12-316. (JCR Q2, IF2.754)(共同第一作者)

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