胥武剑 - 同济大学

个人简介

课题 (Funds) 2022.07 - 2025.06，支气管腔内冷冻去神经术对重症哮喘肺部神经免疫交互作用的影响（在研）上海市科委第一责任人 2013.01 – 2015.12，Nogo-B对肺泡巨噬细胞功能的调控及其与慢性阻塞性肺疾病气道免疫防御的关联性研究（已结题）国家自然科学基金青年基金第一责任人 2015.01 – 2016.12，Nogo-B对肺泡巨噬细胞功能的调控及其与慢性阻塞性肺疾病气道免疫防御的关联性研究（已结题）江苏省博士后课题A类资助第一责任人 2016.12 – 2018.12，GGPPS1调控肺巨噬细胞活化在急性肺损伤中的作用（已结题）中国博士后科学基金特别资助第一责任人 2018.01 - 2021.12，GGPPS1调控肺巨噬细胞NLRP3炎性体启动ARDS炎症瀑布的作用机制（已结题）国家自然科学基金面上项目（主持人：宋勇）第二责任人 2012.01 – 2015.12，Nogo-B调控肺泡巨噬细胞募集在急性肺损伤中的作用及机制研究（已结题）国家自然科学基金面上项目（主持人：李强）第二责任人

研究领域

急性呼吸窘迫综合征的发病机制肺部良、恶性疾病的介入诊疗

近期论文

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Jin J, Qian H, Wan B, Zhou L, Chen C, Lv Y, Chen M, Zhu S, Ye L, Wang X, Xu W, Lv T, Song Y. Geranylgeranyl diphosphate synthase deficiency hyperactivates macrophages and aggravates lipopolysaccharide-induced acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2021;320(6):L1011-L1024. (共同通讯作者, co-corresponding author) Wan B#, Xu WJ#, Chen MZ, Sun SS, Jin JJ, Lv YL, Zhan P, Zhu SH, Wang XX, Lv TF, Song Y. Geranylgeranyl Diphosphate Synthase 1 Knockout Ameliorates Ventilator-Induced Lung Injury via Regulation of TLR2/4-AP-1 Signaling. Free Radic Biol Med. 2020 1;147:159-166. (共同第一作者, co-first author) Wujian Xu#, Xiaoxia Wang #, Bing Wan, Ping Zhan, Guangmin Xi, Guannan Wu, Xiaoling Gu, Suhua Zhu, Wen Ning, Hongbing Liu, Tangfeng Lv, Chaojun Li*, Yong Song* Inhibition of GGPPS1 attenuated endotoxin-induced acute lung injury by suppressing NLRP3 inflammasome. Am J Physiol Lung Cell Mol Physiol. 2019;316(3):L567-L577. (第一作者, first author) Xiaoxia Wang#, Wujian Xu#, Ping Zhan, Tianxiang Xu, Jiajia Jin, Yingying Miu, Zejun Zhou, Qingqing Zhu, Bing Wan, Guangmin Xi, Liang Ye, Yafang Liu, Jianwei Gao, Huijuan Li, Tangfeng Lv, Yong Song. Over-expression of geranylgeranyl diphosphate synthase contributes to tumor metastasis and correlates with poor prognosis of lung adenocarcinoma. Journal of Cellular and Molecular Medicine. 2018;22(4) :2177-2189 (共同第一作者, co-first author) Wujian Xu, Yong Song. Biomarkers for Patients with Trauma Associated Acute Respiratory Distress Syndrome. Mil Med Res.2017 ;4 :25(第一作者, first author) Lin Wu#, Wujian Xu#, Fangyu Wang, Tangfeng Lv, Zhiqiang Yin, Yong Song. Plasma mtDNA Analysis Aids in Predicting Pancreatic Necrosis in Acute Pancreatitis Patients: A Pilot Study. Dig Dis Sci.2018 Nov ;63(11) :2975-2982(共同第一作者, co-first author) Jiajia Jin , Hong Qian , Bing Wan , Li Zhou, Cen Chen, Yanling Lv , Meizi Chen , Suhua Zhu, Liang Ye, Xiaoxia Wang, Wujian Xu, Tangfeng Lv 1 , Yong Song . Geranylgeranyl diphosphate synthase deficiency hyperactivates macrophages and aggravates lipopolysaccharide-induced acute lung injury. AM J PHYSIOL-LUNG C. 2021-06-01;320(6):L1011-L1024. (共同通讯作者, co-corresponding author) Wan, B. , Xu, W. J. , Xu, W. N. , Zhan, P. , Wu, G. N. , & Jin, J. J. , et al. (2017). Plasma long noncoding rna il-7r as a prognostic biomarker for clinical outcomes in patients with acute respiratory distress syndrome. Clin Respir J.2018;12(4) :1607-1614 (第二作者, second author) 9.Xu W#, Zhu Y#, Ning Y, Dong Y, Huang H, Zhang W, Sun Q, Li Q. Nogo-B protects mice against lipopolysaccharide-induced acute lung injury. Sci Rep. 2015;5:12061. (共同第一作者, co-first author) Xu W, Hong W, Shao Y, Ning Y, Cai Z, Li Q. Nogo-B regulates migration and contraction of airway smooth muscle cells by modulating ARPC 2-3 and MYL-9 expression. Respiratory Research Respir Res. 2011;12:14. (第一作者, first author) Zhu Y, Tong Q, Ye J, Ning Y, Xiong Y, Yang M, Xiao H, Lu J, Xu W#, Li J#, Li Q#. Nogo-B Facilitates LPS-Mediated Immune Responses by Up-Regulation of TLR4-Signaling in Macrophage RAW264.7. Cell Physiol Biochem 2017;41:274–285 (共同通讯作者, co-corresponding author) 慢性哮喘肺组织组蛋白去乙酰化酶活性降低对气道平滑肌细胞表型转变的影响.第二军医大学学报 2010;31(9):937-941（论著；第一作者, first author）