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个人简介

哈佛医学院附属Brigham and Women’s 医院心脏科博士后 主持课题 2023上海申康市级医院诊疗技术推广及优化管理项目(SHDC22023223)胸痛中心数字化质量管理平台建设 40万 2022国家自然科学基金(面上项目82270473):平滑肌细胞来源巨噬细胞外捕捉对动脉粥样硬化进展的机制研究 52万 2020国家自然科学基金(面上项目82070230):血管内皮细胞来源的TET2对心室重构的作用和机制研究 55万 2020上海申康第二轮临床三年行动计划(SHDC2020CR4019):基于冠状动脉CTA的血流动力学分析及其对不稳定斑块的预测价值 75万 2019国家自然科学基金(重大培育91939101):血管内皮来源的模式识别受体NLRC5改善血管新生的机制及治疗研究 43万 2016国家自然科学基金(面上项目81670230):microRNA诱导血管平滑肌细胞转分化成内皮细胞的作用和机制研究 57万 2013国家自然科学基金(面上项目81370391):WIF-1基因甲基化修饰对动脉粥样硬化的作用及机制研究 75万 获奖 2010年上海市科技进步三等奖:金属裸支架的基础研究和临床应用 2013上海市医学科技奖三等奖:老年患者心血管风险评估体系的建立及其临床应用

研究领域

冠心病、心肌梗死、肺动脉高压基础、临床研究和介入治疗;心血管多模态影像医学

近期论文

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S Gong, M Zhai, J Shi, G Yu, Z Lei, Y Shi, Y Zeng, P Ju, N Yang, J Zhuang, Q Yu, X Zhang, W Jian, W Wei, and Peng W. TREM2 Macrophage Promotes Cardiac Repair in Myocardial Infarction by Reprogramming Metabolism via SLC25A53. Cell Death & Differentiation. 2023.(IF=11.4) Maimaitiaili N, Zeng Y, Ju P, Zhakeer G, E G, Yao H, Shi Y, Zhai M, Zhuang J, Peng W, Zhuoga D and Yu Q. NLRC3 deficiency promotes hypoxia-induced pulmonary hypertension development via IKK/NF-kappaB p65/HIF-1alpha pathway. Exp Cell Res. 2023:113755. (IF=3.7) Zhong Y, Tang K, Nattel S, Zhai M, Gong S, Yu Q, Zeng Y, E G, Maimaitiaili N, Wang J, Xu Y, Peng W and Li H. Myosin light-chain 4 gene-transfer attenuates atrial fibrosis while correcting autophagic flux dysregulation. Redox Biol. 2023;60:102606. (IF=11.4) Yu Q, Ju P, Kou W, Zhai M, Zeng Y, Maimaitiaili N, Shi Y, Xu X, Zhao Y, Jian W, Feinberg MW, Xu Y, Zhuang J and Peng W. Macrophage-Specific NLRC5 Protects From Cardiac Remodeling Through Interaction With HSPA8. JACC Basic Transl Sci. 2023;8:479-496. (IF=9.7) Jiang Y, Chen R, Peng W, Luo Y, Chen X, Jiang Q, Han B, Su G, Duan Y, Huo J, Qu X, Fu Q and Kan H. Hourly Ultrafine Particle Exposure and Acute Myocardial Infarction Onset: An Individual-Level Case-Crossover Study in Shanghai, China, 2015-2020. Environ Sci Technol. 2023;57:1701-1711. (IF=11.4) Shi Y, Li B, Huang X, Kou W, Zhai M, Zeng Y, You S, Yu Q, Zhao Y, Zhuang J, Peng W and Jian W. Loss of TET2 impairs endothelial angiogenesis via downregulating STAT3 target genes. Cell Biosci. 2023;13:16.(IF=7.5) Zhai M, Gong S, Luan P, Shi Y, Kou W, Zeng Y, Shi J, Yu G, Hou J, Yu Q, Jian W, Zhuang J, Feinberg MW and Peng W. Extracellular traps from activated vascular smooth muscle cells drive the progression of atherosclerosis. Nat Commun. 2022;13:7500.(IF=16.6) Yanxi Zeng, Qing Yu, Nuerbiyemu Maimaitiaili, Bingyu Li, Panjin Liu, Yongzhi Hou, Mima, Cirenguojiee, Yong Liu, Dejizhuoga, Wenhui Peng. Clinical and predictive value of CTA in high-altitude pulmonary hypertension (HAPH) assessment. JACC Asia. 2022. Xu X, Shi Y, Luan P, Kou W, Li B, Zhai M, You S, Yu Q, Zhuang J, Jian W, Feinberg MW and Wenhui Peng. The subcellular redistribution of NLRC5 promotes angiogenesis via interacting with STAT3 in endothelial cells. Theranostics. 2021;11:4483-4501. (IF=12.4) Luan P, Jian W, Xu X, Kou W, Yu Q, Hu H, Li D, Wang W, Feinberg MW, Zhuang J, Xu Y and Wenhui Peng. NLRC5 inhibits neointima formation following vascular injury and directly interacts with PPARgamma. Nat Commun. 2019;10:2882. (IF=16.6) Yu Q, Kou W, Xu X, Zhou S, Luan P, Xu X, Li H, Zhuang J, Wang J, Zhao Y, Xu Y and Wenhui Peng. FNDC5/Irisin inhibits pathological cardiac hypertrophy. Clin Sci (Lond). 2019;133:611-627. (IF=6.0) Zhuang J, Luan P, Li H, Wang K, Zhang P, Xu Y and Wenhui Peng. The Yin-Yang Dynamics of DNA Methylation Is the Key Regulator for Smooth Muscle Cell Phenotype Switch and Vascular Remodeling. Arteriosclerosis, thrombosis, and vascular biology. 2017;37:84-97. (IF=8.7)

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