贾鑫明 - 同济大学

个人简介

2001年毕业于第二军医大学获学士学位，2008毕业于第二军医大学获博士学位，现任同济大学医学院免疫与病原微生物系教授、博士生导师，真菌感染与分子免疫课题组长，同济大学附属第十人民医院科研处处长、科创园区管理办主任。国家自然科学优秀青年基金获得者、教育部“长江学者奖励计划”青年学者、上海市卫计委优秀学科带头人、上海市曙光学者、上海市卫健委“医苑新星”杰出青年医学人才。率领团队围绕“真菌感染与免疫”，系统研究了C型凝集素受体识别真菌的多样性机制，奠定了以C型凝集素受体通路为靶点研发免疫治疗新策略的理论基础。以通讯或共同通讯作者在Immunity、Nat Immunol、Nat Commun、J Exp Med、Sci Adv、Cell Mol Immunol和Clin Transl Med等国际高水平杂志上发表30余篇研究论文，并以第一完成人荣获2020年教育部自然科学一等奖。承担国家重点研发计划项目、国自然优秀青年、面上及青年基金项目、上海市教委自然科学重大项目、上海市科委基础研究重点项目等19项科研项目。担任上海市免疫学会感染免疫专委会副主任委员、中国细胞生物学学会免疫细胞生物学分会理事、上海市免疫学会第十二届理事会理事、中国菌物学会医学真菌专业委员会委员、《中国真菌学》杂志编委。

研究领域

真菌感染的固有免疫识别真菌感染的免疫应答机制真菌感染的免疫调控机制

近期论文

查看导师最新文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Yu Y, Wang RR, Miao NJ, Tang JJ, Zhang YW, Lu XR, Yan PY, Wang J, Jia XM*. PD-L1 negatively regulates antifungal immunity by inhibiting neutrophil release from bone marrow. Nat Commun. 2022 Nov 11;13(1):6857. (*Corresponding author) Li YN, Wang ZW, Li F, Zhou LH, Jiang YS, Yu Y, Ma HH, Zhu LP, Qu JM*, Jia XM*. Inhibition of myeloid-derived suppressor cell arginase-1 production enhances T-cell-based immunotherapy against Cryptococcus neoformans infection. Nat Commun. 2022 Jul 14;13(1):4074. (*Corresponding author) Duan JL, He HQ, Yu Y, Liu T, Ma SJ, Li F, Jiang YS, Lin X, Li DD, Lv QZ, Ma HH, Jia XM*. E3 ligase c-Cbl regulates intestinal inflammation through suppressing fungi-induced noncanonical NF-κB activation. Sci Adv. 2021 May 7(19): eabe5171. (*Corresponding author). Lv QZ, Li DD, Han H, Yang YH, Duan JL, Ma HH, Yu Y, Chen JY, Jiang YY*, Jia XM*. Priming with FLO8-deficient Candida albicans induces Th1-biased protective immunity against lethal polymicrobial sepsis. Cell Mol Immunol. 2021 Aug;18(8):2010-2023. (*Corresponding author) Wang W, Ding CL, Wu MX, Guo W, Hu R, Liu Y, Qi ZT, Jia XM*. RAI16 maintains intestinal homeostasis and inhibits NLRP3-dependent IL-18/CXCL16-induced colitis and the progression of colitis-associated colorectal cancer. Clin Transl Med. 2022 Aug;12(8):e993. (*Corresponding author) Jiang Y, Li F, Li Y, Duan J, Di C, Zhu Y, Zhao J, Jia X*, Qu J*. CD69 mediates the protective role of adipose tissue-derived mesenchymal stem cells against Pseudomonas aeruginosa pulmonary infection. Clin Transl Med. 2021 Nov;11(11): e563. (*Corresponding author) Xu X; Xu JF; Zheng G; Lu HW; Duan JL; Rui W; Guan JH; Cheng LQ; Yang DD; Wang MC; Lv QZ; Li JX; Zhao X; Chen CX; Shi P; Jia XM*; Lin X*, CARD9S12N facilitates the production of IL-5 by alveolar macrophages for the induction of type 2 immune responses. Nat Immunol. 2018 Jun;19(6):547-560. (*Corresponding author) Zhu LL, Luo TM, Xu X, Guo YH, Zhao XQ, Tang B, Jiang YY, Lin X*, Jia XM*. E3-ubiquitin-ligase Cbl-b negatively regulates C-type lectin receptor-mediated anti-fungal innate immunity. J Exp Med. 2016 Jul 25;213(8):1555-70. (*Corresponding author) Jia XM*, Tang B, Zhu LL, Zhao XQ, Gorjestani S, Hsu YS, Xu GT, Lin X*. CARD9 mediates Dectin-1-induced ERK activation by linking Ras-GRF1 to H-Ras for anti-fungal immunity. J Exp Med. 2014 Oct 20; 211(11):2307-21. (*Corresponding author) Zhu LL, Zhao XQ, Jiang C, You Y, Chen XP, Jiang YY, Jia XM*, Lin X*. C-Type Lectin Receptors Dectin-3 and Dectin-2 Form a Heterodimeric Pattern-Recognition Receptor for Host Defense against Fungal Infection. Immunity, 2013 Aug 22, 39(2): 324–334. (*Corresponding author, recomended by Faculty of 1000) Zhao XQ, Zhu LL, Chang Q, Jiang C, You Y, Jia XM*, Lin X*. C-type lectin receptor Dectin-3 mediates trehalose 6,6‘-dimycolate (TDM)-induced Mincle expression through CARD9/Bcl10/MALT1-dependent NF-ĸB activation. J Biol Chem. 2014; 289(43):30052-62. (*Corresponding author)