当前位置: X-MOL首页全球导师 国内导师 › 高山峨

研究领域

再生医学中自体脂肪干细胞治疗损伤或退行性疾病。采用基因组整合或非整合的方式并结合小分子诱导的方式重编程人源脂肪干细胞分化为各种组织器官的功能细胞或其前体细胞,并进行临床级治疗用中间体种子细胞的生产。利用各种临床相关的动物疾病模型研究干细胞及中间体种子细胞治疗的疗效和作用机制

近期论文

查看导师最新文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

Jian Wang?, Rui Hao?, Tianfang Jiang?, Xuanxuan Guo, Fei Zhou, Limei Cao, Fengjuan Gao, Guangming Wang, Juan Wang, Ke Ning, Chunlong Zhong*, Xu Chen*, Ying Huang*, Jun Xu*, and Shane Gao*,Rebuilding Hippocampus Neural Circuit with hADSC-derived Neuron Cells for Treating Ischemic Stroke, Cell & Bioscience, 2022 (Pre-print) (IF=7.13) 人源脂肪干细胞通过重建海马神经环路治疗缺血性脑卒中。 Xuanxuan Guo1?, Chenqi Lu2?, Yaqun Lu1?, Simeng Zhao3, Jian Wang1, Juan Wang4, Fei Zhou5, Qiang Li6*, Chunlong Zhong1*, Shane Gao1*,Human adipose-derived stem cells (hADSCs) proceed through the neural stem cell stage before committing their neuron or motor neuron cell fate, iScience, 2022 (Pre-print) (IF=5.8) 人源脂肪干细胞干细胞在向神经细胞或运动神经元分化命运开启前需要经历神经干细胞阶段。 Shane Gao, XuanXuan Guo, Simeng Zhao, Yinpeng Jin, Fei Zhou, Ping Yuan, Limei Cao, Jian Wang, Yue Qiu, Chenxi Sun, Zhanrong Kang, Guisheng Zhong*, Liming Cheng*, Hongwen Zhu*, Zhengliang Gao*, Xu Chen*, Jun Xu*, Differentiation of human adipose-derived stem cells into neuron/motoneuron-like cells for cell replacement therapy of spinal cord injury, Cell Death & Disease, 2019 Aug; 10(8): 597(IF=8.469).人脂肪干细胞分化为神经元/运动神经元样细胞用于脊髓损伤、细胞死亡和疾病的细胞替代治疗。 Li Q?, Gao S?, Kang Z, Zhang M, Zhao X, Zhai Y, Huang J, Yang G-Y, Sun W* and Wang J*, Rapamycin Enhances Mitophagy and Attenuates Apoptosis After Spinal Ischemia-Reperfusion Injury. Front. Neurosci. 2018,12:865.(IF=4.677).雷帕霉素增强脊髓缺血-再灌注损伤后线粒体吞噬和减少细胞凋亡。 Jin Y, Wang J, Li H, Gao S, Shi R, Yang D, Wang X, Wang X, Zhu L, Wang X, Chen C, Ning K, Gao Z*, Xu J*, Fu Q*. Extracellular Vesicle Secreted by Human Adipose-Derived Stem cells (hASCs) Improve Survival Rate of Rats with Acute Liver Failure by Releasing lncRNA H19. EBioMedicine, 2018, Aug 34:231-242 (IF=8.143).人脂肪源性干细胞(hADSCs)分泌的胞外囊泡通过释放lncRNA H19提高急性肝功能衰竭大鼠的存活率 Tianfang Jiang, Gen Li, Jun Xu, Shane Gao*, Xu Chen*. The Challenge of the Pathogenesis of Parkinson's Disease: Is Autoimmunity the Culprit? Front Immunol. 2018, 9: 2047.(IF=7.561).帕金森氏症发病机制的挑战:自身免疫是罪魁祸首吗? Rongjie Ma, Min Wang, Shane Gao, Liang Zhu, Liming Yu, Daiyu Hu, Luying Zhu,Wei Huang, Weihua Zhang, Jiajia Deng, Jie Pan, Hua He, Zhengliang Gao, Jun Xu*, Xinxin Han*. miR-29a Promotes the Neurite Outgrowth of Rat Neural Stem Cells by Targeting Extracellular Matrix to Repair Brain Injury, Stem Cells Dev. 2019 Dec; 12: (IF=3.272). miR-29a通过靶向细胞外基质促进大鼠神经干细胞神经突生长修复脑损伤。 Wang G, Wang F, Ren J, Qiu Y, Zhang W, Gao S, Yang D, Wang Z, Liang A, Gao Z, Xu J. SIRT1 Involved in the Regulation of Alternative Splicing Affects the DNA Damage Response in Neural Stem Cells. Cell Physiol Biochem, 2018, 48(2):657-669. (IF=5.5). SIRT1参与调节选择性剪接对神经干细胞DNA损伤反应的影响 Gao FJ?, Gao S?, Chen X, Sun J, Wang JY, Anti-inflammatory effect of stem cells in the treatment of ischemic stroke, Chinese Journal of Tissue Engineering Research, 2017, 21(25):4088-4093. (IF=1.272) 干细胞在治疗缺血性脑卒中中的抗炎效果。 Wang J, Li JX, Yang Jian, Zhang Liang LG, Gao S, Jiao F, Yi ML, Xu J. MicroRNA-138-5p regulates neural stem cell proliferation and differentiation in vitro by targeting TRIP6 expression. Mol Med Rep. 2017, 16(5): 7261–7266. (IF=2.952) MicroRNA-138-5p 通过TRIP 6调控神经干细胞的增殖和分化。 Zhou F ?, Gao S ?, Wang L ?, Sun C, Chen L, Yuan P, Zhao H, Yi Y, Qin Y, Dong Z, Cao L, Ren H, Zhu L, Li Q, Lu B, Liang A, Xu GT, Zhu H, Gao Z, Ma J*, Xu J*, Chen X*. Human adipose-derived stem cells partially rescue the stroke syndromes by promoting spatial learning and memory in mouse middle cerebral artery occlusion model. Stem Cell Res Ther. 2015, 6(1):92-104.(IF=6.832)人源脂肪干细胞通过提高中风小鼠的学习记忆能力改善其中风症状。 Gao S?, Zhao P?, Lin C, Sun Y, Wang Y, Zhou Z, Yang D, Wang X, Xu H, Zhou F, Cao L, Zhou W, Ning K, Chen X*, Xu J*. Differentiation of human adipose-derived stem cells into neuron-like cells which are compatible with photocurable three-dimensional scaffolds. Tissue Eng Part A. 2014, 20(7-8):1271-1284. (IF=3.845)人源脂肪干细胞通过与3D 光敏感生物材料结合实现神经分化。 Zhou F?, Gao S?, Sun C, Cao L, Ren H, Li Q, Wang G, Dong C, Zhu L, Yang D, Wang X, Xu J*, Chen X*. Adipose-derived stem cells in stroke treatment: translational possibility and mechanism. Chin Med J (Engl). 2014, 127(20):3657-3663. (IF=2.628)脂肪干细胞治疗中风:转化可能性和机理。 Shi S?, Gao S?, Cao T, Liu J, Gao X, Hao J, Lv C, Huang H, Xu J*, Yao T*. Targeting Human Telomeric G-Quadruplex DNA and Inhibition of Telomerase Activity With [(dmb)2Ru(obip)Ru(dmb)2]4+, PLos One, 2013, 8(12).e84419. (IF=3.240) [(dmb)2Ru(obip)Ru(dmb)2]4+ 通过结合端粒末端G-Quadruplex DNA结构抑制端粒酶活性。 Yang DJ, Wang XL, Ismail A, Ashman CJ, Valori CF, Wang G, Gao S, Higginbottom A, Ince PG, Azzouz M, Xu J*, Shaw PJ*, Ning K*, PTEN regulates AMPA receptor-mediated cell viability in iPS-derived motor neurons,Cell Death & Disease, 2014, 5(e1096). (IF=8.469)PTEN 通过调节AMPA调控iPS分化的运动神经元。 Dong CM, Wang XL, Wang GM, Zhang WJ, Zhu L, Gao S, Yang DJ, Qin Y, Liang QJ, Chen YL, Deng HT, Ning K, Liang AB, Gao ZL, Xu J. A stress-induced cellular aging model with postnatal neural stem cells, Cell Death & Disease, 2014, 5(e1116).(IF=8.469) 应激诱导的产后神经干细胞细胞老化模型。 Shane Gao ?*, Juan Wang ?, Zeyang Wu, Ping Yuan, Fengjuan Gao, Fei Zhou, Limei Cao, Xu Chen, Hongwen Zhu, Jun Xu, Do the Stem Cells Really Work with Autism Spectrum Disorders Associated with Neuro-Immune Interaction? Autism Open Access, 2015, 5(3):151-157. 干细胞真的能治疗与神经免疫相互作用相关的自闭症谱系障碍吗? 论著、专家共识及会议论文 中国抗癌协会肿瘤与微生态专业委员会.肿瘤与微生态领域:高山峨(同济大学医学院)肠道微生态与造血干细胞移植相关性中国专家共识[J].国际肿瘤学杂志,2021,48(03):129-135. Cancer and Microecology Committee of Chinese Anti-Cancer Association, Oncology and microecology, Shane Gao (Medical College of Tongji University) Chinese expert consensus on the correlation between intestinal microecology and hematopoietic stem cell transplantation, International Journal of Oncology, 2021,48(03):129-135. Translational Medicine Research (Series Title), Translational Research in Stroke (Book Title), Paul A. Lapchak and Guo yuan Yang (Eds) (ISBN: 978-981-10-5803-5). 2017年出版。(论著,本人参编)中风的转化研究。 Gao S #*, Zhou F, Chen X, Xu J, human Adipose Derived Stem Cells Can Partially Rescue the Memory and the Spacial Learning of Stroke Mice,BIT 7th Annual World Congress of Regenerative Medicine & Stem Cells, Oral Presentation, 2014.11.13-2014.11.16. 会议论文,人脂肪干细胞能部分挽救中风小鼠的记忆和空间学习功能。 Gao S#*, Wang J, Xu J, Transdifferentiation of human adipose-derived stem cells (hADSCs) into motoneuron-like cells for cell replacement therapy in spinal cord injury, BIT 8th Annual World Congress of Regenerative Medicine & Stem Cells, Oral Presentation, 2015.11.18-2015.11.20. 会议论文,人脂肪源性干细胞(hADSCs)转分化为运动神经元样细胞用于脊髓损伤的细胞替代治疗。 Gao S#* Fengjuan Gao, XuChen, Jun Xu, Transdifferentiation of human adipose-derived stem cells (hADSCs) into neuron-like cells for cell replacement therapy in Middle Cerebral Artery Occlusion mouse model, Tissue Engineering & Regenerative Medicine International Society- Asia Pacific Meeting, Invited Oral Presentation, 2016.09.03-2016.09.06. 特邀会议报告,在大脑中动脉闭塞小鼠模型中,人脂肪来源干细胞(hADSCs)转分化为神经元样细胞用于细胞替代治疗。 Attending International Society for Stem Cell Research (ISSCR), Guangzhou 2017.11.10- 2017.11.12.参加国际干细胞研究协会(ISSCR),广州,2017.11.10- 2017.11.12。 Tai Wan Tsing Hua University Specially Invited Communication Report, “hADSC derived intermediate cell source for Parkinson Disease Treatment”. 2019.2.11 特邀交流报告 台湾清华大学特邀交流报告,人源脂肪干细胞转化而来的中间体细胞对帕金森的治疗,2019.2.11。 East Hospital Craniocerebral Trauma and Neurology Intensive Forum, “human Adipose-Derived Stem Cells and Neural Regeneration”. 2020.12.04 特邀报告 东方医院颅脑创伤与神经病学集中论坛, 人源脂肪干细胞与神经再生,2020.12.04。 2021年应邀参加“International Conference on Neuro & Brain Disorders”作题为“Rebuilding of a Neuronal Circuit via Cell Replacement with hADSC-derived Neuron Cells for Treating Ischemic Stroke”专题汇报,2021.11.15。 2021年应邀参加“神经和大脑疾病国际会议”,作题为“hADSC衍生神经元细胞通过细胞替换重建神经回路治疗缺血性中风” 专题汇报,2021.11.15。

学术兼职

《Frontiers in Neuroscience》,专刊主编 《Chinese Tissue Engineering Research》、《Clinical Intervention in Aging》、《Journal of Cellular and Molecular Medicine》、《Molecular and Cellular Biochemistry》、《Clinical Intervention in Aging》、《Biophysics Reports》等审稿专家

推荐链接
down
wechat
bug