姜冬阳 - 同济大学

个人简介

同济大学附属第十人民医院泛血管研究所研究员。本科毕业于北京大学基础医学专业，博士毕业于北京大学免疫学专业，之后加入十院从事心血管疾病基础研究。中国免疫学会会员，中国生物化学与分子生物学会会员，美国心脏学会会员，Biochemical Pharmacology、International Journal of Molecular Sciences、Frontiers in Physiology等杂志审稿人。研究成果共发表SCI论文15篇，总影响因子89.2，其中以第一或通讯作者在ATVB、Cancer letters、British Journal of Pharmacology等国际高水平期刊发表SCI论文7篇。作为项目负责人承担国自然面上项目、青年项目等国家级项目，中国博士后面上项目、上海市科委项目等省部级项目，获美国心脏学会年会青年科学家旅行奖等国际及国内科研奖励。

研究领域

泛血管疾病中炎症信号通路的基础与转化研究调控内皮细胞屏障损伤的信号通路研究靶向Caspase-4/11在泛血管疾病治疗中的转化研究

近期论文

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Dongyang Jiang#*, Hao Liu#, Guofu Zhu#, Xiankai Li, Linlin Fan, Ze Yu, Shumin Wang, Jordan Rhen, Yiheng Yin, Yuling Gu, Xiangbin Xu, Edward A. Fisher, Junbo Ge, Yawei Xu*, Jinjiang Pang*. Endothelial PHACTR1 promotes endothelial activation and atherosclerosis by repressing PPARγ activity under disturbed flow in mice. Arteriosclerosis, Thrombosis, and Vascular Biology. 2023 Aug;43(8):e303-e322. Linlin Fan#, Hao Liu, Guofu Zhu, Shekhar Singh, Ze Yu, Shumin Wang, Hong Luo, Shiying Liu, Yawei Xu, Junbo Ge*, Dongyang Jiang*, Jinjiang Pang*. Caspase-4/11 is critical for angiogenesis by repressing Notch1 signaling via inhibiting γ-secretase activity. British Journal of Pharmacology. 2022 Oct;179(20):4809-4828. Qianqian Wang#, Dongyang Jiang#, Qing Ye#, Wenjing Zhou#, Junfan Ma, Chong Wang, Zihan Geng, Ming Chu, Jie Zheng, Hongchengcheng Chen, Jing Huang, Hui Dai, Youhui Zhang, Zhan-Long She, Ning Fu*, Xiaoyan Qiu*. A widely expressed free immunoglobulin κ chain with a unique Vκ4-1/Jκ3 pattern promotes colon cancer invasion and metastasis by activating the integrin β1/FAK pathway. Cancer Letters. 2022 Aug 1;540:215720. Shumin Wang#, Guofu Zhu#, Dongyang Jiang#, Jordan Rhen, Xiankai Li, Hao Liu, Yuyan Lyu, Patrick Tsai, Yara Rose, Tiffany Nguyen, R. James White, Gloria S. Pryhuber, Thomas J. Mariani, Chen Li, Amy Mohan, Yawei Xu, Jinjiang Pang*. Reduced Notch1 cleavage promotes the development of pulmonary hypertension. Hypertension. 2022;79:79–92. Dongyang Jiang#, Jianhui Zhuang#, Wenhui Peng, Yuyan Lu, Hao Liu, Qian Zhao, Chen Chi, Xiankai Li, Guofu Zhu, Xiangbin Xu, Chen Yan, Yawei Xu, Junbo Ge, Jinjiang Pang*. Phospholipase Cγ1 mediates intima formation through Akt-Notch1 signaling independent of the phospholipase activity. Journal of the American Heart Association. 2017, 6(7): e005537. Dongyang Jiang#, Jing Ge, Qinyuan Liao, Junfan Ma, Yang Liu, Jing Huang, Chong Wang, Weiyan Xu, Jie Zheng, Wenwei Shao, Gregory Lee, Xiaoyan Qiu*. IgG and IgA with potential microbial-binding activity are expressed by normal human skin epidermal cells. International Journal of Molecular Sciences. 2015, 16(2): 2574-2590.