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个人简介

现任上海市第十三届政协委员,民建市委第十三届委员会常委,民建同济大学委员会第四届主委,曾担任国家自然科学基金委员会第十三、十四届、2014年、2016年生命科学部专家评审组成员,第九、十、十一届中国生物化学与分子生物学理事、第一、二、三届蛋白质专委会委员、上海市生物化学与分子生物学学会第十、十一届理事, 十二届副理事长、常务理事。1988年7月毕业于阜阳师范学院获学士学位,1988年7月至1990年8月在安徽科技学院任教,1996年6月毕业于中国科技大学获博士学位,1996年6月来同济大学工作至今。其间1999年9月至2000年5月在杨浦区科委挂职锻炼,任杨浦区科委副主任,2000年5月至2002年1月在美国Cornell University生物化学系 从事博士后研究工作。2006年4月至2016年9月任生命科学与技术学院副院长。已主持或参与国家、省部级项目30余项,已在国外核心杂志上发表被SCI收录的学术论文130余篇,主编出版60余万字的“蛋白质化学”教材一本,申请专利10余项,授权专利6项,已指导出站博士后3名,毕业博士生21名,硕士生40余名。

研究领域

1. 纳米材料对干细胞的分化和更新研究 2. 纳米材料作为治疗哮喘、炎症、肿瘤等药物载体的研制 3. 脊髓损伤修复的纳米仿生支架研制

生物学

近期论文

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Linnan Yang, Jing Sun, Qiang Liu, Rongrong Zhu, Qiannan Yang, Jiahui Hua, Longpo Zheng, Kun Li, Shilong Wang,* and Ang Li*,Synergetic Functional Nanocomposites Enhance Immunotherapy in Solid Tumor via Remodeling Immunoenvironment,Advanced Science. 2019, 1802012. If=12. 441 Guoxin Jing, Zhaojie Wang, Xizhen Zhuang, Xiaolie He, Huijun Wu,Qingxiu Wang, Liming Cheng, Zhongmin Liu, Shilong Wang**, Rongrong Zhu* Suspended graphene oxide nanosheets maintain the self-renewal of mouse embryonic stem cells via down-regulating the expression of Vinculin,Biomaterials,2018,171,1-11。If=8.806 Zhaojie Wang1, Peng Liang1, Xiaolie He1, Bin Wu1, Qiang Liu1, Ziping Xu1,Zhongmin Liu1, Yechang Qian*2,Shilong Wang*1, Rongrong Zhu* Etoposide loaded layered double hydroxide nanoparticles reversing chemoresistance and eradicating human glioma stem cells in vitro and in vivo,Nanoscale, 2018, 10, 13106–13121 If=7.233 Qiang Liu, Jiao Wang, Linnan Yang, Xiaofei Xia, Mei Wang, Shengguang Chen, Rongrong Zhu, Qingxiu Wang, Xianzheng Wu and Shilong Wang*,Facile Synthesis by a Covalent Binding Reaction for pH-responsive Drug Release of Carboxylated Chitosan Coated Hollow Mesoporous Silica Nanoparticles ,IET Nanobiotechnol., 2018, 12(4),446-452. If=2.059 Bin Wu, Rongrong Zhu, Mei Wang, Peng Liang, Yechang Qian* and Shilong Wang*,Fluorescent carbon dots from antineoplastic drug etoposide for bioimaging in vitro and in vivo,Journal of Materials Chemistry B,2017 If=4.543 Xiaolie He, Li Yang, Mei Wang, Xizhen Zhuang, Ruiqi Huang, Rongrong Zhu*, Shilong Wang*,Targeting the Endocannabinoid/CB1 Receptor System For Treating Major Depression Through Antidepressant Activities of Curcumin and DexanabinolLoaded Solid Lipid Nanoparticles, cellular physiology and biochemistry, 2017;42:2281-2294 , If=5.104 Liang Wang? , Bin Wu? , Weitao Li, Zhen Li, Jing Zhan, Bijiang Geng, Shilong Wang*, Dengyu Pan,* Minghong Wu*,Industrial production of ultra-stable sulfonated graphene quantum,dots for Golgi apparatus imaging,Journal of Materials Chemistry B, Journal of Materials Chemistry B , 2017, 5, 5355-5361 If=4.543 Shan Jiang, Rongrong Zhu, Xiaolie He, Jiao Wang, Mei Wang, Yechang Qian*, Shilong Wang* Enhanced Generation of Reactive Oxygen Species from Curcumin induce a Remarkable Photocytotoxicity Delivered by Solid Lipid Nanoparticles,International Journal of Nanomedicine, 2017:12,167-178 If=4.32 Jiao Wang, Yue Wang, Qiang Liu, Linnan Yang, Rongrong Zhu, Chengzhong Yu**, Shilong Wang** Rational Design of Multifunctional Dendritic Mesoporous Silica Nanoparticles to Load curcumin and Enhance Efficacy for Breast Cancer Therapy,ACS Applied Materials & Interfaces,2016 If=8.097 Zhu, R., Wang, Q., Zhu, Y., Wang, Z., Zhang, H., Wu, B., Wu, X., Wang, S., pH sensitive nano layered double hydroxides reduce the hematotoxicity and enhance the anticancer efficacy of etoposide on nonsmallcell lung cancer, Acta Biomaterialia Acta Biomaterialia, 2016, 29: 320–332 If=6.025 Yanjing Zhu, Rongrong Zhu *, Mei Wang, Xiaolie He, Yechang Qian*,Shilong Wang*,Anti-metastatic and Anti-angiogenic activities of Core-shell SiO2@LDH loaded with Etoposide in Non-small Cell Lung Cancer, advanced science,2016, If=12. 441 Hongjian He, Mingyu Liu, Junjie Wei, Ping Chen,* Shilong Wang,* and Qigang Wang* Hydrogel with Aligned and Tunable Pore Via “Hot Ice” Template Applies as Bioscaffold,Adv. Healthcare Mater. 2016, DOI: 10.1002/ adhm If=4.88 Xiaolie He#, Yanjing Zhu#, Mei Wang, Guoxin Jing, Rongrong Zhu* and Shilong Wang*,Antidepressant effects of curcumin and HU-211 co-encapsulated solid lipid nanoparticles against corticosterone-induced cellular and animal models of major depression, Int J Nanomedicine, 2016. If=4.32 Qing Wu,Zhaoqi Wang, Haixia Zhang, Rongrong Zhu, Shilong Wang* and Qigang Wang*, Fe3O4@Nanogel via UOx/HRP Initiated Surface Polymerization for pHSensitive Drug Delivery. RSC Advances, 2016,6(58):53170-53174. If=3.289 Haixia Zhang, Yanjing Zhu, Xiaoyu Sun, Xiaolie He, Mei Wang, Zhaoqi Wang, Qingxiu Wang, Rongrong Zhu* and Shilong Wang*, Curcumin Loaded Layered Double Hydroxide Nanoparticles-Induced Autophagy for Reducing Glioma Cell Migration and Invasion,J. Biomed.Nanotechnol. 2016,If=3.929 Tingting Qian, MeiWang , JiaoWang, Rongrong Zhu, Xiaolie He, Xiaoyu Sun, Dongmei Sun, Qingxiu Wang*, ShiLongWang*,Transient spectra study on photo-dynamics of Curcumin, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy,2016: 16638–43。 If=2.653 Jiao Wang, Haoyue Wang, Rongrong Zhu, Qiang Liu, Jian Fei*, Shilong Wang *, Anti- inflammatory activity of curcumin-loaded solid lipid nanoparticles in IL-1b transgenic mice subjected to the lipopolysaccharide-induced sepsis. Biomaterials ,2015,53, 475-483. If=8.557 Youjun Wu, Rongrong Zhu, Yang Zhou, Jun Zhang, Wenrui Wang, Xiaoyu Sun,Xianzheng Wu, Liming Cheng, Jing Zhang* and Shilong Wang*,Layered double hydroxide nanoparticles promote self-renewal of mouse embryonic stem cellsthrough the PI3K signaling pathway, Nanoscale, 2015, 7:11102–11114 If=7.394 Youjun Wu, Rongrong Zhu, Xin Ge,Xiaoyu Sun, Zhaoqi Wang, Wenrui Wang, Mei Wang, Hui Liu* & Shilong Wang*,Size dependent effects of layered double hydroxide nanoparticles on cellular functions of mouse embryonic stem cells, Nanomedicine, 2015, 10(23):3469-82. If= 5.413 Yanjing Zhu, Youjun Wu, Haixia Zhang, Zhaoqi Wang, Yechang Qian*, Rongrong Zhu*, Shilong Wang*, The enhanced anti-metastasis efficiency of etoposide by the delivery of LDH nanoparticles through caveolae-mediated cellular uptake and the regulation of mTOR/AKT and STAT pathways, J. Biomed.Nanotechnol. 2015, 11(12):2158-2168, If=5.338 Jiao Wang, Rongrong Zhu, Dongmei Sun, Xiaoyu Sun, Zhengsong Geng, Hui Liu*, Shi-Long Wang* Intracellular Uptake of Curcumin-Loaded Solid Lipid Nanoparticles Exhibit Anti-inflammatory Activities Superior to Those of Curcumin through the NF-B Signaling Pathway, J. Biomed. Nanotechnol. 2015, 11, 403–415 If=5.338 Wen-Rui Wang, Ang Li, Wei Mei, Rong-Rong Zhu, Kun Li, Xiao-Yu Sun, Ye-Chang Qian* and Shi-Long Wang*, Dexamethasone sodium phosphate intercalated layered double hydroxides and their therapeutic efficacy in a murine asthma model, RSC Adv., 2015, 5, 23826–23834 If=3. 84 Dongmei Sun, Haibao Peng, Shilong Wang* and Dazhang Zhu* Synthesis of CaCO3 Nanobelts for Drug Delivery in Cancer Therapy,Nanoscale Research Letters, 2015, 10:239 doi:10.1186/s11671-015-0948-6,If=2.779 Chenchen Zhang, Shan Jiang, Kun Li, Mei Wang, Rongrong Zhu, Xiaoyu Sun, Qingxiu Wang, ShiLong Wang *, The triplet state of tanshinone I and its synergic effect on the phototherapy of cancer cells with curcumin,Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy , 2015, 150(5):181–186, If=2.353

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