研究领域
1、器官再生的细胞与分子生物学机制
2、器官前体细胞诱导分化机理
实验室研究方向为器官再生机理及诱导哺乳动物器官再生的途径。
主要研究内容为爪蛙、蝾螈与小鼠动物器官再生的细胞及分子生物学、表观遗传及代谢调控机制。此外，实验室亦致力于利用诱导多能干细胞（iPSC）探讨多能前体细胞移植在器官损伤修复与再生中的应用前景。实验室已建立了三维培养诱导类肢芽器官及获取肢芽前体细胞、通过移植含有胚胎肢芽前体细胞和生长因子组合的凝胶纤维蛋白骨架（fibrin scaffold）建立了诱导断肢再生的技术方法，可以促进小鼠断趾再生。
近期论文
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Book Chapters
Chen Y, Lin G*. (2014). Xenopus model for regeneration. XenopusDevelopment, Edited by Kubiak J & Kloc M. Willy-Blackwell Publishing. *corresponding author
Leng H, Lin G* and Chen Y*. (2013). Cellular Origins of Amphibian Regeneration. Progenitor Cells: Biology, Characterization and Potential Clinical Applications, Edited by Horton P. and Lawrence B. Nova Publishers, New York (book chapter). *corresponding author
Peer-reviewed publications
Tai X, Xue S, Zhang C, Liu Y, Chen J, Han Y, Lin G*, Zhang C*. Pharmacological evaluation of MRAP proteins on Xenopus neural melanocortin signaling. J Cell Physiol. 2021 Jan 31. doi: 10.1002/jcp.30306. PMID: 33521982.
Xu H, Zhang H, Fang Y, Yang H, Chen Y, Zhang C, Lin G*. Activation of the Melanocortin-4 receptor signaling by a-MSH stimulates nerve-dependent mouse digit regeneration. Cell Regeneration, 2021 May 3;10(1):19. doi: 10.1186/s13619-021-00081-9.
Li L, Zheng J, Xu Y, Kuang Z, Zhang C, Li N, Lin G*, Zhang C*. Pharmacological modulation of dual melanocortin-4 receptor signaling by melanocortin receptor accessory proteins in the tetrapod Xenopus Laevis. J Cell Physiol. 2021;236:5980-5993. https://doi.org/10.1002/jcp.30280.
Shen J, Hu L, Yang L, Zhang M, Sun W, Lu X, Lin G, Huang C, Zhang X, Chin YE. (2020) Reversible Acetylation Modulates Dishevelled-2 Puncta Formation in Canonical Wnt Signaling Activation. Sig Transduct Target Ther. 06 July 2020.
Lin G*, Chen Y. Limb regeneration under check by the nervous system. (2018) Chinese J Cell Biol. DOI: 10.11844/cjcb.2018.11.0202. *corresponding author. Review.
Zhang M, Chen Y, Xu H, Yang L, Yuan F, Li L, Xu Y, Chen Y*, Zhang C*, and Lin G* (2018). Melanocortin receptor 4 (Mc4r) signaling regulates vertebrate limb regeneration. Dev Cell.2018.46: 397-409. *corresponding author
Zhang M, Yang L, Yuan F, Chen Y, and Lin G*. Dicer inactivation stimulates limb regeneration ability in Xenopus laevis. Wound Repair and Regeneration. 2018. 26:46-53. *corresponding author
Chen Y, Xu H, Lin G*. Generation of iPSC-derived limb progenitor-like cells for stimulating phalange regeneration in the adult mouse Cell Discovery 2017 (3), 17046; doi:10.1038/celldisc.2017.46. *corresponding author
Lin H, Zhu X, Chen G, Song L, Gao L, Khand A, Chen Y, Lin G* and Tao Q*. KDM3A-mediated demethylation of histone H3 lysine 9 facilitates the chromatin binding of Neurog2 during neurogenesis. Development 2017, 144:3674-3685. *corresponding author
Pai, V.P., Lemire, J.M., Chen, Y., Lin, G., and Levin, M. (2015). Local and long-range endogenous resting potential gradients antagonistically regulate apoptosis and proliferation in the embryonic CNS. Int J Dev Biol. 2015, 59:327-340.
Pai V, Lemire JM, Pare JF, LinG, Chen Y and Levin M. (2015) Endogenous gradients of resting potential instructively pattern neural tissue via Notch signalling. J. Neurosci.35: 4366–4385.
Shi X, Jai R, Zirbes K, Gong W, Lin G, Kyba M, Thomson J, Koyano-Nakagawa N and Garry D. (2014). Cooperative interaction of Etv2 and Gata2 regulates the development of endothelial and hematopoietic lineages Dev. Biol. 389, 208–218..
Lin G**, Chen Y.* and Slack JMW*. (2013). Imparting regenerative capacity to limbs by progenitor cell transplantation. Dev. Cell 24: 41-51 * equal contributor. * corresponding author. (F1000prime recommended)
Lin G*, Chen Y. and Slack JMW. (2012). Transgenic analysis of signaling pathways required for Xenopus tadpole spinal cord and muscle regeneration. Anat. Rec. 295: 1532-1540. * corresponding author.
Chen Y, Lin G, Chen Y, Fok A and Slack JMW. (2012).Micro-computed tomography for visualizing limb skeletal regeneration in young Xenopus frogs. Anat. Rec. 295: 1562-1565.
Lin G and Slack JMW. (2008). Requirement for Wnt and FGF signaling in Xenopus tadpole tail regeneration. Dev Biol. 316: 323-335.
Slack JMW, Lin G and Chen Y. (2008). The Xenopus tadpole: a new model for regeneration research. Cell Mol Life Sci. 65: 54-63.
Lin G, Chen Y and Slack JMW. (2007). Regeneration of neural crest derivatives in the Xenopus tadpole tail. BMC Dev Biol 7, 56.
Chen Y, Lin, G. and Slack, J. M. (2006). Control of muscle regeneration in the Xenopus tadpole tail by Pax7. Development 133, 2303-13.
Lin G, Geng X, Chen Y, Qu B, Wang F, Hu R and Ding X. (2003). T-box binding site mediates the dorsal activation of myf-5 in Xenopus gastrula embryos. Dev Dyn 226, 51-8.
Wu K, Weng Z, Lin G, Wu X, Li F and Zhang Y. (2005). The effect of breast cancer specific gene 1 in the prognosis of breast cancer. Chinese Journal of Surgery. 43:294-7 (in Chinese).
Wu K, Weng Z, Lin G, Yin M, Qian H, Zhang Y, Ding X. (2004). Significance of breast cancer specific gene 1 expression in breast cancer. Shanghai Medical Journal. 27:193-5 (in Chinese).
Lin G, Geng X, Chen Y, Qu B, Wang F, Hu R and Ding X. (2003). T-box binding site mediates the dorsal activation of myf-5 in Xenopus gastrula embryos. Dev Dyn 226, 51-8.
Geng X, Xiao L, Lin G, Hu R, Wang JH, Rupp RA and Ding X. (2003). Lef/Tcf-dependent Wnt/beta-catenin signaling during Xenopus axis specification. FEBS Lett 547, 1-6.
Chen Y#, Lin G#, Hu R, Chen Y and Ding X. (2003). Activin/Nodal signals mediate the ventral expression of myf-5 in Xenopus gastrula embryos. Biochem Biophys Res Commun 310, 121-7. #equal contributor.
Wu K, Weng Z, Tao Q, Lin G, Wu X, Qian H, Zhang Y, Ding X, Jiang Y, Shi YE. (2003). Stage-specific expression of breast cancer-specific gene gamma-synuclein. Cancer Epidemiol Biomarkers Prev. 12: 920-5.
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