个人简介

1999年毕业于湖北师范大学，获学士学位。2002年毕业于华中师范大学，获硕士学位。2005年毕业于中科院水生生物研究所，获博士学位，期间获得中国科学院地奥一等奖学金。2005-2009在中科院上海生化细胞所进行博士后研究,，期间获得上海市博后基金、中科院王宽诚博后奖励基金，发现microRNA在Th17细胞分化、多发性硬化症（Multiple sclerosis, MS）发病中的重要调控功能，提示microRNA在MS的诊断及治疗中的潜在应用前景(Nat Immunology, 2009, 10: 1252-1259)。2009年11月进入同济大学生命科学与技术学院任副教授，2017年晋升教授并成立独立研究团队，任首席科学家，2021年兼聘同济医院脊柱脊髓损伤再生修复教育部重点实验室研究员。 主要研究以多发性硬化症（MS）为代表的自身免疫疾病的发病机制，解析新的治疗靶点。近年来重点研究了microRNA、G蛋白偶联受体（G protein-coupled receptors, GPCR）等分子在 T细胞的激活、分化、凋亡、及迁移异常中的作用，取得了一系列研究成果：揭示了T细胞分化及MS疾病调控的microRNA新机制；发现T细胞激活相关细胞因子分泌的新信号转导通路；阐明了白三烯受体在T细胞迁移异常中的调控作用；发现老药VPA在治疗MS疾病中的新用途及机制；揭示了阿片受体在调控髓鞘恢复及MS发生中的新功能。第一及通讯作者成果发表于Nature Immunology、Nature Communications、Cell Research、Journal of Immunology、JBC、CMI等杂志，受到同行的广泛关注：Nature Immunology、Nature China、Science Signaling、Faculty of 1000等发表了对我们工作的专评，获得Science杂志子刊Science Signaling的“编辑选择奖”（Editors’ Choice）以及MS疾病的著名网站MS Discovery Forum的（Editors’ Pick）。并被Nature Medicine，Nature Immunology，Lancet，Immunity，Blood，PNAS，Nature Review Immunology，Nature Review Neurology，Nature Review Rheumatology等杂志多次引用，发表在Nature Immunology论文被他人引用超过800次。

研究领域

Th1/Th2/Th17/Treg细胞分化调控机制 基于G蛋白偶联受体的治疗靶点发现与药物筛选 自身免疫疾病的发病机理解析和诊治新策略研究 自身免疫系疾病的治疗药物发现 分子检测、诊断技术开发

分子免疫/信号转导

近期论文

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Liu G*, Zhang Y*, Han S, Zhuang W, Lv J, Han M, Xie L, Jiang X, Wang C, Saimaier K, Shen J, and Du C#. TPN10466 ameliorates Concanavalin A-induced autoimmune hepatitis in mice via inhibiting ERK/JNK/p38 signaling pathway. Eur J Immunol, 2023, 53: e2250100. DOI:10.1002/eji.202250100. Wang C*, Lv J*, Zhu Q, Zhuang W, Xie L, Liu G, Saimaier K, Shi C, Hua Q, Yue R, and Du C#. Novel evaluation indicators of MOG35~55 induced experimental autoimmune encephalomyelitis in C57BL/6J mice. Immunobiology, 2023, 228: 152341. Lv J, Han M, Xiang Z, Gong R, Shi C, Hua Q, Zhang R, Du C#. Chlorzoxazone Alleviates Experimental Autoimmune Encephalomyelitis via Inhibiting IL-6 Secretion of Dendritic Cells. J Immunol, 2022, 208(7):1545–1553. Wang C*, Lv J*, Zhuang W, Xie L, Liu G, Saimaier K, Han S, Shi C, Hua Q, Zhang R, Shi G#, Du C#. Induction and Diverse Assessment Indicators of Experimental Autoimmune Encephalomyelitis. JOVE, 2022, 187: e63866; DOI:10.3791/63866. Liu G*, Yang J*, Han M, Lv J, Zhuang W, Xie L, Zhang Y, Wang C, Saimaier K, Yang J, Shen J#, Li N#, Du C#. Artemisinin derivative TPN10466 suppresses immune cell migration and Th1/Th17 differentiation to ameliorate disease severity in experimental autoimmune encephalomyelitis. Cell Immunol, 2022, 373:104500; doi.org/10.1016/j.cellimm.2022.104500. Han M*, Li Y*, Huang Y, Wang G, Du C#, Wang Q#, Zhang G#. Integrated co-expression network analysis uncovers novel tissue-specific genes in major depressive disorder and bipolar disorder. Front Psychiatry, 2022, 13:980315; doi.org/10.3389/fpsyt.2022.980315. Feng J, Zhu F, Ye D, Zhang Q, Guo X#, Du C#, Kang J#. Sin3a drives mesenchymal-to-epithelial transition through cooperating with Tet1 in somatic cell reprogramming. Stem Cell Res Ther, 2022, 13(29); doi: 10.1186/s13287-022-02707-4. Wang C*, Yang J*, Xie L, Saimaier K, Zhuang W, Han M, Liu G, Lv J, Shi G, Li N#, Du C#. Methyl Butyrate Alleviates Experimental Autoimmune Encephalomyelitis and Regulates the Balance of Effector T Cells and Regulatory T Cells. Inflammation, 2022, 45: 977-991. Xie L*, Saimaier K*, Wang C, Yang J, Han M, Lv J, Zhuang W, Liu G, Du C#. Methyl acetate arrests Th1 in peripheral immune system and alleviates CNS inflammation in EAE. Int Immunopharmacol, 2021:108291. Lv J*, Zhuang W*, Zhang Y*, Xie L, Xiang Z, Zhao Q, Jiang X, Shen J#, Du C#. 9,10-Anhydrodehydroartemisinin Attenuates Experimental Autoimmune Encephalomyelitis by Inhibiting Th1 and Th17 Cell Differentiation. Inflammation, 2021, 44(5):1793-1802. Yang C*, Lv J*, Jiang X*, Xiang Z, Gong R, Xing J, Liu G, Xie L, Saimaier K, Zhang Y, Wang J, Shen H, Pan J, Shen J#, Du C#. The novel small-molecule TPN10456 inhibits Th17 cell differentiation and protects against experimental autoimmune encephalomyelitis. Cell Mol Immunol, 2020, 17(12):1290-1293. Cai Y*, Yang C*, Yu X, Qian J, Dai M, Wang Y, Qin C, Lai W, Chen S, Wang T, Zhou J, Ma N, Zhang Y, Zhang R, Shen N, Xie X, Du C#. Deficiency of beta-Arrestin 2 in Dendritic Cells Contributes to Autoimmune Diseases. J Immunol, 2019, 202(2):407-420. Zhou J*, Lai W*, Yang W, Pan J, Shen H, Cai Y, Yang C, Ma N, Zhang Y, Zhang R, Xie X, Dong Z, Gao Y#, Du C#. BLT1 in dendritic cells promotes Th1/Th17 differentiation and its deficiency ameliorates TNBS-induced colitis. Cell Mol Immunol, 2018, 15(12):1047-1056. Yang C, Lai W, Zhou J, Zheng X, Cai Y, Yang W, Xie S, Gao Y#, Du C#. Betaine Ameliorates Experimental Autoimmune Encephalomyelitis by Inhibiting Dendritic Cell-Derived IL-6 Production and Th17 Differentiation. J Immunol, 2018, 200(4):1316-1324. Qin C*, Zhou J*, Gao Y*, Lai W, Yang C, Cai Y, Chen S, Du C#. Critical Role of P2Y12 Receptor in Regulation of Th17 Differentiation and Experimental Autoimmune Encephalomyelitis Pathogenesis. J Immunol, 2017, 199(1):72-81. Lai W*, Cai Y*, Zhou J, Chen S, Qin C, Yang C, Liu J, Xie X, Du C#. Deficiency of the G protein Galphaq ameliorates experimental autoimmune encephalomyelitis with impaired DC-derived IL-6 production and Th17 differentiation. Cell Mol Immunol, 2017, 14(6):557-567. Cai Y, Shen H, Qin C, Zhou J, Lai W, Pan J#, Du C#. The Spatio-Temporal Expression Profiles of CD4+ T Cell Differentiation and Function-Related Genes During EAE Pathogenesis. Inflammation, 2017, 40(1):195-204. Du C*, Duan Y*, Wei W, Cai Y, Chai H, Lv J, Du X, Zhu J, Xie X#. Kappa opioid receptor activation alleviates experimental autoimmune encephalomyelitis and promotes oligodendrocyte-mediated remyelination. Nat Commun, 2016, 7:11120. Du C, Xie X#. G protein-coupled receptors as therapeutic targets for multiple sclerosis. Cell Res, 2012, 22(7):1108-1128. Du C*, Liu C*, Kang J, Zhao G, Ye Z, Huang S, Li Z, Wu Z, Pei G#. MicroRNA miR-326 regulates TH-17 differentiation and is associated with the pathogenesis of multiple sclerosis. Nat Immunol, 2009, 10(12):1252-1259.