个人简介

2009年毕业于内蒙古大学，获理学学士学位。2016年毕业于中国科学院北京基因组研究所，获理学博士学位，博士阶段主要从事定量蛋白质组学相关研究。2016年至2022年在美国希望之城国家医疗中心（City of Hope）贝克曼研究所（Beckman Research Institute）从事博士后研究工作，并任科学家职员（Staff Scientist）。2022年入选上海市海外高层次人才计划。2023年3月至今，任同济大学生命科学与技术学院特聘研究员，同济大学附属东方医院科创中心特聘研究员。主要从事iPSC向大脑类器官、神经细胞和免疫细胞的定向分化，用于神经系统疾病和肿瘤免疫治疗的相关研究。近年以第一作者（含共同）发表Advanced Science，Cell Reports Medicine及Journal of Proteomics等多篇学术论文。

研究领域

诱导多功能干细胞（iPSC）向神经细胞和大脑类器官的定向分化 阿尔茨海默病（AD）的类器官疾病模型的构建，分子机制的研究及潜在治疗方法的开发 iPSC向免疫细胞的定向分化及肿瘤免疫疗法的研究与开发

干细胞与神经退行性疾病

近期论文

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X Chen, G Sun, E Tian, M Zhang, H Davtyan, TG Beach, EM Reiman, M Blurton-Jones, D Holtzman, Y Shi. Modeling sporadic Alzheimer’s disease in human brain organoids. Advanced Science 8, e2101462 (2021). G Sun*, F Chiuppesi*, X Chen*, C Wang, E Tian, J Nguyen, M Kha, D Trinh, H Zhang, MC Marchetto, H Song, G Ming, FH Gage, DJ Diamond, F Wussow, Y Shi. Modeling human cytomegalovirus-induced microcephaly in human iPSC-derived brain organoids. Cell Reports Medicine 1, 100002 (2020). X Chen, Q Yang, Z Liu, Y Shi. Chapter 2 - Human induced pluripotent stem cell–based modeling of Alzheimer’s disease, a glial perspective. Editor(s): Alexander Birbrair. In Advances in Stem Cell Biology, iPSCs for Modeling Central Nervous System Disorders, Academic Press, Volume 6, 2021, Pages 21-35. L Li*, E Tian*, X Chen, J Chao, J Klein, Q Qu, G Sun, G Sun, Y Huang, CD Warden, P Ye, L Feng, X Li, Q Cui, A Sultan, P Douvaras, V Fossati, NE Sanjana, AD Riggs, Y Shi. GFAP mutations in astrocytes impair oligodendrocyte progenitor proliferation and myelination in an hiPSC model of Alexander disease. Cell stem cell 23 (2), 239-251. e6 (2018). Q Cui, K Yin, X Zhang, P Ye, X Chen, J Chao, H Meng, J Wei, D Roeth, L Li, Y Qin, G Sun, M Zhang, J Klein, M Huynhle, C Wang, L Zhang, B Badie, M Kalkum, C He, C Yi, Y Shi. Targeting PUS7 suppresses tRNA pseudouridylation and glioblastoma tumorigenesis. Nature Cancer 1-18 (2021). C Wang, M Zhang, G Garcia, E Tian, Q Cui, X Chen, G Sun, J Wang, V Arumugaswami, Y Shi. ApoE-Isoform-Dependent SARS-CoV-2 Neurotropism and Cellular Response. Cell Stem Cell 28(2):331-342.e5 (2021). L Feng, J Chao, E Tian, L Li, P Ye, M Zhang, X Chen, Q Cui, G Sun, T Zhou, G Felix, Y Qin, W Li, ED Meza, J Klein, L Ghoda, W Hu, Y Luo, W Dang, D Hsu, J Gold, SA Goldman, R Matalon, Y Shi. Cell‐Based Therapy for Canavan Disease Using Human iPSC‐Derived NPCs and OPCs. Advanced Science. 7 (23), 2002155 (2020). X Chen, Y Zhu, Z Wang, H Zhu, Q Pan, S Su, Y Dong, L Li, H Zhang, L Wu, X Lou, S Liu. mTORC1 alters the expression of glycolytic genes by regulating KPNA2 abundances. Journal of Proteomics 136: 13-24 (2016). X Chen, D Guo, Y Zhu, F Xian, S Liu, L Wu, X Lou. Nuclear Phosphoproteomics Analysis Revealed that CDK1/2 were Involved in EGF-Regulated Constitutive Pre-mRNA Splicing in MDA-MB-468 Cells. Journal of Proteomics 141:77-84 (2016). Y Zhu, X Chen, Q Pan, Y Wang, S Su, C Jiang, Y Li, N Xu, L Wu, X Lou, and S Liu. A Comprehensive Proteomics Analysis Reveals a Secretory Path, Cell Type and Status-Dependent Signature of Exosomes Released from Tumor Associated Macrophages. Journal of Proteome Research 14 (10): 4319-4331 (2015).