张建宏 - 清华大学

研究领域

从纤维化发生机制到抗纤维化药物研发张建宏的科研重点是人类多器官纤维化发生的机理，纤维化治疗靶点的系统性发现，抗纤维化多肽或蛋白质药物研发。主要研究方向包括肺脏、肝脏、肾脏和心脏等器官的纤维化发生机理及治疗靶点。他利用单细胞多组学和细胞分子免疫学的最新技术，绘制纤维化的组织微环境单细胞图谱，揭示非免疫细胞和免疫细胞间的相互作用网络和调控关系，深度挖掘纤维化发生过程中的基因组和蛋白组学变化，鉴定纤维化发生的重要调控分子，为抗纤维化药物研发提供新的靶点。

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Jianhong Zhang#, Mengmeng Cao#, Jiahong Dong, Changyan Li, Wangxiang Xu, Yiqun Zhan, Xiaohui Wang, Miao Yu, Changhui Ge, Zhiqiang Ge, Xiaoming Yang*, ABRO1 suppresses tumourigenesis and regulates the DNA damage response by stabilizing p53, Nature Communications, 2014, 5: 5059 Guangming Ren, Xuanyi Zhang, Yang Xiao, Wen Zhang, Yu Wang, Wenbing Ma, Xiaohan Wang, Hui Chen, Yiqun Zhan, Jianhong Zhang, Miao Yu, Changhui Ge, Changyan Li, Ronghua Yin*, Xiaoming Yang*, ABRO1 promotes NLRP3 inflammasome activation through regulation of NLRP3 deubiquitination, EMBO J. 2019, 38(6): e100376 Jianhong Zhang, Yao Di, Liying Wu, Yunlin He, Tong Zhao, Xin Huang, Xuefeng Ding, Kuiwu Wu, Ming Fan, Lingling Zhu, 5-HMF prevents against oxidative injury via APE/Ref-1, Free Radical Res, 2015.1, 49(1): 86~94 Xiaodong Feng#, Liwei Li#, Jianhong Zhang#, Yunping Zhu, Cheng Chang, Kunxian Shu, Jie Ma*, Using the entrapment sequence method as a standard to evaluate key steps of proteomics data analysis process, BMC Genomics, 2017, 18 (Suppl 2) :143