刘念 - 清华大学 - 生命科学学院

个人简介

2010年／中国科学技术大学／学士 2015年／芝加哥大学／博士 2015-2019年／斯坦福大学／博士后 2019年-2022年／清华大学生命科学学院-生命科学联合中心／助理教授 2022年-至今／清华大学生命科学学院-生命科学联合中心／副教授荣誉、奖励及参加学术团体的情况 Bayer Investigator Award (2020) Jane Coffin Child Foundation Fellowship (2016-2019) RNA Society / Scaringe Graduate Student Award (2016) Award for Outstanding Self-financed Students Abroad (2016) Aldrich Alfred R. Bader Award for Student Innovation (2015)

研究领域

转座子是可以移动（或转座）的DNA，存在于几乎所有的生命体中，属于基因组中的“暗物质”。转座子在人体内大量富集，占据大约一半的人体DNA，并且仍然具有转座活性。人体转座子的活性与胚胎发育、神经发育以及上百种疾病密切相关，但是其相关机理和功能至今不是非常清楚。我们利用分子、细胞、生化、高通量测序和生物统计等手段主攻转座子活性是如何被调控的机理，及其在发育和疾病中的具体功能

近期论文

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Liu, N.*, Lee, C.*, Swigut, T., Grow, E., Gu, B., Bassik, M., and Wysocka, J. Selective silencing of euchromatic L1s revealed by genome-wide screens for L1 regulators. Nature 553, 228-232 (2018). Liu, N., Dai, Q., Zheng, G., He, C., Parisien, M., Pan, T. N6-methyladenosine-dependent RNA structural switches regulate RNA–protein interactions. Nature 518, 560-564 (2015). Liu, N.*, Pan, T.* N6-methyladenosine-coded RNA Epigenetics. Nat. Struct. Mol. Biol. 23, 98-102 (2016). Liu, N.*, Zhou, K.*, Parisien, M., Dai, Q., Diatchenko, L., and Pan, T. N6-methyladenosine alters RNA structure to regulate binding of a low-complexity protein. Nucleic Acids Res. 45 (10), 6051-6063 (2017). Liu, N., Parisien, M., Dai, Q., Zheng, G., He, C., and Pan, T. Probing N6-methyl-adenosine RNA modification status at single nucleotide resolution in mRNA and long noncoding RNA. RNA 19, 1848-1856 (2013). Liu, N., Pan, T. RNA epigenetics (Epitranscriptomics). Translating epigenetics to the clinic 19-30 (2017). ( Book chapter) Liu, N.,Pan, T. Probing N6-methyl-adenosine (m6A) RNA modification in total RNA with SCARLET. Post-transcriptional gene regulation 1358, 285-292 (2016). Liu, N.,Pan, T. Probing RNA modification status at single nucleotide resolution in messenger and long non-coding RNA. Methods in enzymology 560, 149-159 (2015). ( Book chapter) Liu, N., Pan, T. RNA epigenetics. Translational research 165, 28-35 (2015). Zhou, K., Parisien, M., Dai, Q., Liu, N., Diatchenko, L., Sachleben, J., Pan, T. N6-methyladenosine modification in a long noncoding RNA hairpin predisposes its conformation to protein binding. Journal of molecular biology 428, 822-33 (2016). Chen, K., Lu, Z., Wang, X., Fu, Y., Luo, G., Liu, N., Han, D., Dominissini, D., Dai, Q., Pan, T., He, C. High-resolution N6-methyladenosine (m6A) map using photo-crosslinking-assisted m6A sequencing. Angewandte chemie 127, 1607-1610 (2015).