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余刚,长聘教轨副教授,课题组长,博士生导师 教育与科研经历 2022.6-至今 上海交通大学农业与生物学院,课题组长,博士生导师 2016.7-2022.5 中科院分子植物科学卓越创新中心 (上海植物逆境生物学研究中心),博士后 2013.9-2015.9 美国加州大学戴维斯分校 (UC Davis),植物病理系,联合培养博士 2010.9-2016.6 吉林大学,植物科学学院,植物学博士 2006.9-2010.6 吉林大学,植物科学学院,植物保护本科 ORCID: https://orcid.org/0000-0002-6720-7490 基金项目 (1) 植物根系对病原细菌的天然免疫分子机制解析,国家自然科学基金面上项目, 2022.1-2024.12,主要参与人 (2/5); (2) 植物性状形成的环境塑造机制(病原体侵染与植物营养代谢相互作用的机制研究),中国科学院战略性先导科技专项(B类),2018-2023,主要参与人 (2/4); (3) 番茄青枯病菌效应子蛋白Rip32生化与生物学功能解析,中国博士后基金一等资助, 2016.11-2018.11,主持人; 本课题组研究方向 青枯菌是造成茄科作物(马铃薯,番茄,辣椒、茄子等)发生青枯病的罪魁祸首,青枯病是农业生产上重要的土传病害(特别在我国南方热带、高湿地区),难以根治。当前人们对植物抗病的理解,大多来源于前期植物叶部研究数据,但植物与病原微生物互作很多时候发生于根部,土传病害大流行是农业生产上重要问题,而相关理论基础研究远滞后于叶部病害研究。 课题组将以茄科作物与青枯菌分子互作为研究模式,从茄科作物与病原细菌两个方面开展工作,核心回答茄科作物抗病机制解析及挖掘利用抗病基因这个重要问题。主要包括: 1. 效应子蛋白操纵植物免疫分子机制。 2. 细胞壁主动参与抗病反应分子机制。 3. 新型抗病受体蛋白挖掘及应用。 招生和招聘 欢迎对本课题组研究方向感兴趣的优秀博士生应聘博士后和专职科研岗; 欢迎有植物病理学、遗传学和生物化学背景的学生报考本实验室硕士、博士研究生及免推硕博生; 欢迎本科生到本课题组做实验实习,参与科研项目,毕业设计。

研究领域

植物与病原细菌分子互作

近期论文

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(12) Hao Xue#, Gang Yu#, Lu Zhang, Meng Li, Rosa Lozano-Duran*, and Alberto P. Macho*. Ralstonia solanacearum alters root developmental programs in auxin-dependent and independent manners. 2022, bioRxiv, doi: 10.1101/2022.06.22.497157. (11) Gang Yu#, Maria Derkacheva#,*, Jose S. Rufian#, Carla Brillada, Kathrin Kowarschik, Shushu Jiang, Paul Derbyshire, Miaomiao Ma, Thomas A. DeFalco, Rafael J. L. Morcillo, Lena Stransfeld, Yali Wei, Jian-Min Zhou, Frank L.H. Menke, Marco Trujillo, Cyril Zipfel*, and Alberto P. Macho*. The Arabidopsis E3 ubiquitin ligase PUB4 regulates BIK1 and is targeted by a bacterial type-III effector. 2022, EMBO Journal (accepted), bioRxiv, doi: 10.1101/2020.10.25.354514. (10) Suhui Lv#, Yu Yang#, Gang Yu#, Li Peng, Shuai Zheng, Sunil Kumar Singh, Juan Ignacio Vílchez, Richa Kaushal, Hailing Zi, Dian Yi, Yuhua Wang, Shaofan Luo, Xiaoxuan Wu, Ziwei Zuo, Weichang Huang, Renyi Liu, Jiamu Du, Alberto P Macho, Kai Tang, Huiming Zhang*. Dysfunction of histone demethylase IBM1 in Arabidopsis causes autoimmunity and reshapes the root microbiome. ISME Journal, 2022, doi: 10.1038/s41396-022-01297-6. (9) Liping Wang#*, Gang Yu#*, Alberto P. Macho, and Rosa Lozano-Duran. Split-luciferase complementation imaging assay to study protein-protein interactions in Nicotiana benthamiana. Bio-protocol, 2021, 11(23): e4237. (8) Gang Yu*, Liu Xian, Haiyan Zhuang and Alberto Macho*. SGT1 is not required for plant LRR-RLK-mediated immunity. Molecular Plant Pathology, 2021, 22: 145-150. (7) Gang Yu, Liu Xian, Hao Xue, Wenjia Yu, Jose Rufian, Yuying Sang, Rafael Morcillo, Yaru Wang, and Alberto P. Macho*. A bacterial effector protein prevents MAPK-mediated phosphorylation of SGT1 to suppress plant immunity. PLoS Pathogens, 2020, 16(9):e1008933. (6) Liu Xian#, Gang Yu#, Yali Wei, Yansha Li, Hao Xue, Rafael J. L. Morcillo, Jose S. Rufian, and Alberto P. Macho*. A bacterial effector protein hijacks plant metabolism to support bacterial nutrition. Cell Host & Microbe, 2020, 28(4): 548-557. (5) Gang Yu, Liu Xian, Yuying Sang, Alberto P. Macho*. Cautionary notes on the use of Agrobacterium-mediated transient gene expression upon SGT1 silencing in Nicotiana benthamiana. New Phytologist, 2019, 222: 14-17. (4) Ling Liu, Qiaochu Wang, Ying Sun, Yanhua Zhang, Xianghui Zhang, Jinliang Liu, Gang Yu*, and Hongyu Pan*. Sssfh1, a gene encoding a putative component of the RSC chromatin remodeling complex, is involved in hyphal growth, reactive oxygen species accumulation, and pathogenicity in Sclerotinia sclerotiorum. Frontiers in Microbiology, 2018, 9: 1828. (3) Xinhua Sun, Gang Yu*, Jingtao Li, Jinliang Liu, Xueliang Wang, Genglin Zhu, Xianghui Zhang, and Hongyu Pan*. AcERF2, an ethylene-responsive factor of Atriplex canescens, positively modulates osmotic and disease resistance in Arabidopsis thaliana. Plant Science, 2018, 274: 32-43. (2) Gang Yu, Jingtao Li, Xinhua Sun, Yanzhi Liu, Xueliang Wang, Hao Zhang, and Hongyu Pan*. Characterization of salinity tolerance genes expressed in salt-treated Atriplex canescens, IJMS, 2017, 18(11), 2444. (1) Jingtao Li#, Gang Yu#, Xinhua Sun, Yanzhi Liu, Jinliang Liu, Xianghui Zhang, Chengguo Jia, Hongyu Pan*. AcPIP2, a plasma membrane intrinsic protein from halophyte Atriplex canescens, enhances plant growth rate and abiotic stress tolerance when overexpressed in Arabidopsis thaliana, Plant Cell Reports, 2015, 24(8): 1401-1415. 学术期刊发表的非第一作者论文 (8) Julian Dindas#, Thomas A. DeFalco#, Gang Yu, Lu Zhang, Pascale David, Marta Bjornson, Marie-Christine Thibaud, Valéria Custódio, Gabriel Castrillo, Laurent Nussaume, Alberto P. Macho, and Cyril Zipfel*. Direct inhibition of phosphate transport by plant immune signaling. Current Biology, 2022, 32 (2), 488-495. (7) Yanru Wang#, Liu Xian#, Gang Yu, and Alberto P. Macho*. Tomato stem injection for the precise assessment of Ralstonia solanacearum fitness in planta. Bio-protocol, 2021, 11(16): e4134. (6) Liu Xian, Gang Yu, and Alberto P. Macho*. The GABA transaminase GabT is required for full virulence of Ralstonia solanacearum in tomato. microPublication Biology, 2021, DOI: 10.17912/micropub.biology.000478. (5) Yaru Wang, Rafael Morcillo, Achen Zhao, Gang Yu, Hao Xue, Jose S. Rufian, Yuying Sang, and Alberto P. Macho*. A bacterial effector uncovers a metabolic pathway involved in resistance to bacterial wilt disease. Molecular Plant, 2021, 14(8):1281-1296. (4) Yuying Sang#, Wenjia Yu#, Haiyan Zhuang, Yali Wei, Lida Derevnina, Gang Yu, Jiamin Luo, Alberto P. Macho*. Intra-strain elicitation and suppression of plant immunity by Ralstonia solanacearum type-III effectors in Nicotiana benthamiana. Plant Communications, 2020: 10.1016/j.xplc.2020.100025. (3) Huidong Fan, Gang Yu, Yanzhi Liu, Xianghui Zhang, Jinliang Liu, Yanhua Zhang, Jeffery A. Rollins, Fengjie Sun, and Hongyu Pan*. An atypical forkhead containing transcription factor SsFkh1 is involved in sclerotial formation and is essential for pathogenicity in Sclerotinia sclerotiorum, Molecular Plant Pathology, 2017, 18(7):963-975. (2) Jingtao Li, Gang Yu, Xinhua Sun, Xianghui Zhang, Jinliang Liu and Hongyu Pan*. AcEBP1, an ErbB3-Binding Protein (EBP1) from halophyte Atriplex canescens, negatively regulates cell growth and stress responses in Arabidopsis, Plant Science, 2016, 248: 64-74. (1) DongHyuk Lee, Gildas Bourdais, Gang Yu, Silke Robatzek, and Gitta Coaker*. RIN4 phosphorylation enhances plant plasma membrane H+-ATPase activity and inhibits flagellin-triggered immune responses. The Plant Cell, 2015, 27 (7):2042-2056.

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