个人简介

刘路,长聘教轨副教授，博士生导师，独立PI 教育背景： 2004-2008 云南大学，本科 2008-2013 新加坡国立大学，博士 工作经历： 2012-2013 淡马锡生命科学研究所，新加坡，初级研究员 2013-2020 淡马锡生命科学研究所，新加坡，博士后研究员 2020.06-至今 上海交通大学，农业与生物学院，长聘教轨副教授 获奖情况及荣誉： 2013: Gold Medal of International Society of Plant Molecular Biology, National University of Singapore 2010: Excellent Teaching Assistant Award AY 2009/2010, National University of Singapore

研究领域

细胞间通讯和植物生长发育

植物作为一个多细胞生物个体，它利用可移动的信号分子（如信号肽、RNA、激素、蛋白质等）来完成细胞间信息的传递，以此适应不断变化的外界环境。近些年，越来越多的证据表明，跨细胞运输的转录调控因子对植物自身形态建成及生长发育的精准调控发挥着极其重要的作用。对此类转录调控因子进行细胞生物学和分子生物学的深入研究，了解其跨细胞运输的调控方式，将对未来农业的发展带来积极的促进效果。 本课题组综合运用分子遗传学、系统生物学、细胞生物学和生物显微影像学等手段，解析生物大分子在细胞间和细胞内的运输对植物生长发育、自身形态建成以及响应外界环境的影响。主要研究方向如下： 1. 植物开花素和开花抑制素的调控、转运及作用机制； 2. 植物大分子蛋白在细胞内转导及跨细胞运输对植株形态建成的影响； 3. 植物蛋白转运在时间和空间上的调控，以及对外界环境和植物内源激素的响应； 4. Multiple C2 Domain and Transmembrane Region Proteins (MCTPs)家族蛋白在植物膜转运系统中的功能。

近期论文

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Liu Lu#, Zhang Yu, Yu Hao# (2020) Florigen trafficking integrates photoperiod and temperature signals in Arabidopsis. Journal of Integrative Plant Biology 62:1385-1398. (# co-corresponding author) Li Chunying*, Liu Lu*, Teo Zhi Wei Norman, Shen Lisha, Yu Hao (2020) Nucleoporin 160 regulates flowering through anchoring HOS1 for destabilizing CO in Arabidopsis. Plant Communications 1, 100033. (* these authors contributed equally) Liu Lu, Li Chunying, Teo Zhi Wei Norman, Zhang Bin, Yu Hao (2019) The MCTP-SNARE complex regulates florigen transport in Arabidopsis. Plant Cell 31:2475-2490. Issue Highlights Liu Lu, Li Chunying, Song Shiyong, Teo Zhi Wei Norman, Shen Lisha, Wang Yanwen, Jackson David, Yu Hao (2018) FTIP-dependent STM trafficking regulates shoot meristem development in Arabidopsis. Cell Reports 23: 1879-1890. Featured in Faculty of 1000 Biology Liu Lu, Li Chunying, Liang Zhe, Yu Hao (2018) Characterization of multiple C2 domain and transmembrane region proteins in Arabidopsis. Plant Physiology 176: 2119-2132. Liu Lu, Zhu Yang, Shen Lisha, Yu Hao (2013). Emerging insights into florigen transport. Current Opinion in Plant Biology 16: 607-613. Liu Lu*, Liu Chang*, Hou Xingliang, Xi Wanyan, Shen Lisha, Tao Zhen, Wang Yue, Yu Hao (2012). FTIP1 is an essential regulator required for florigen transport. PLoS Biology 10: e1001313. (* these authors contributed equally) Issue Highlights; Featured in Faculty of 1000 Biology; Embodied in Plant Physiology and Development, Sixth Edition Song Shiyong, Chen Ying, Liu Lu, See Yen How Benjamin, Mao Chuanzao, Gan Yinbo, Yu Hao (2018) OsFTIP7 determines auxin-mediated anther dehiscence in rice. Nature Plants 4: 495-504. Wang Yanwen, Liu Lu, Song Shiyong, Li Yan, Shen Lisha, Yu Hao (2017) DOFT and DOFTIP1 affect reproductive development in the orchid Dendrobium Chao Praya Smile. Journal of Experimental Botany 68: 5759-5772. Song Shiyong, Chen Ying, Liu Lu, Wang Yanwen, Bao Shengjie, Zhou Xuan, Teo Zhi Wei Norman, Mao Chuanzao, Gan Yinbo, Yu Hao (2017) OsFTIP1-mediated regulation of florigen transport in rice is negatively regulated by the ubiquitin-like domain kinase OsUbDKγ4. Plant Cell 29: 491-507. Zhu Yang, Liu Lu, Shen Lisha, Yu Hao (2016) NaKR1 regulates long-distance movement of FLOWERING LOCUS T in Arabidopsis. Nature Plants 2: 16075. Featured in Faculty of 1000 Biology Shen Lisha, Liang Zhe, Gu Xiaofeng, Chen Ying, Teo Zhi Wei Norman, Hou Xingliang, Cai Weiling Maggie, Dedon Perter C., Liu Lu, Yu Hao (2016) N6-methyladenosine RNA modification regulates shoot stem cell fate in Arabidopsis. Developmental Cell 38: 186-200. Hou Xingliang, Zhou Jiannan, Liu Chang, Liu Lu, Shen Lisha, Yu Hao (2014) Nuclear Factor Y-mediated H3K27me3 demethylation of the SOC1 locus orchestrates flowering responses of Arabidopsis. Nature Communications 5: 4601. Tao Zhen, Shen Lisha, Liu Chang, Liu Lu, Yan Yuanyuan, Yu Hao (2012). Genome-wide identification of SOC1 and SVP targets during the floral transition in Arabidopsis. Plant Journal 70:549-561. Shen Lisha, Kang Yin Ga Germain, Liu Lu, Yu Hao (2011) The J-domain protein J3 mediates the integration of flowering signals in Arabidopsis. Plant Cell 23, 499-514. Fang Lei, Hou Xingliang, Lee Li Yen Candy, Liu Lu, Yan Xiaojing, Yu Hao (2011). AtPV42a and AtPV42b redundantly regulate reproductive development in Arabidopsis thaliana. PLoS One 6: e19033.