个人简介
Sijia Yan, assistant researcher, Ph. D., graduated from College of Life Sciences, Fudan University in biochemistry and molecular biology in 2017. Her research interests include disease-related proteomics and development of molecular markers for detection of trace clinical samples, pharmacogenomics, etc. She has participated in several basic and preclinical drug experimental studies. Including the development of mitochondrial protective agents, prediction of adverse drug reactions, and other related research results were published in Frontiers in Pharmacology, The Pharmacogenomics Journal, Pharmacogenetics and Genomics. In 2019, she was funded by the "Sailing Plan" project of Shanghai Science and Technology Commission, and participated in many important scientific research projects such as the National Natural Science Foundation project and the National Key Research and Development Program project.
Research Interests: Trace detection of disease related protein markers
严思嘉，助理研究员，理学博士，2017年毕业于复旦大学生命科学学院生物化学与分子生物学专业，专业方向为疾病蛋白组学，痕量临床样本检测分子标志物的研发，药物基因组学等，参与过多项基础及临床前药物实验研究，包括线粒体保护剂开发，药物不良反应预测等，相关研究成果发表于Frontiers in Pharmacology，The Pharmacogenomics Journal，Pharmacogenetics and Genomics等。2019年获上海市科委“扬帆计划”项目资助，参与国家自然科学基金面上项目，国家重点研发计划项目等多项重要科研项目。
近期论文
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1. Sijia Yan, HaoXiong, Lin He, Fanping Yang, Menglin Jiang, Xiaoqun Luo, Qinghe Xing, et al. HLA-C*1201 is associated with Xuesaitong-induced cutaneous adverse drug reactions in Chinese patients [J] The Pharmacogenomics Journal, 2018.
2. Sijia Yan, Sheng-an Chen, Wen Zhang, Qinghe Xing et al. HLA-A*02 alleles are associated with tetanus antitoxin-induced exanthematous drug eruptions in Chinese patients [J]. Pharmacogenetics & Genomics, 2016, 26(12).
3. Sijia Yan, Lu Y, He L, et al. Dynamic Editome of Zebrafish under Aminoglycosides Treatment and Its Potential Involvement in Ototoxicity[J]. Frontiers in Pharmacology, 2017, 8:854.
4. Feng Zhang, Yulan Lu, Sijia Yan, Qinghe Xing, Weidong Tian. SPRINT: A SNP-free toolkit for identifying RNA editing sites. [J] Bioinformatics, 2017, 33 (22)
5. Hongzhe Tian, Rumeng Tan, Bogen Ye , Sijia Yan, Mingxing Sui, et al. SHP-1 inhibits renal ischemia reperfusion injury via dephosphorylating ASK1 and suppressing apoptosis. [J]M Biochemical and Biophysical Research Communications 513 (2019) 360e367
6. Fanping Yang, Bo Gu, Lirong Zhang, Jiekun Xuan, Heng Luo, Peng Zhou, Qinyuan Zhu, Sijia Yan, et al. HLA-B*13:01 is associated with salazosulfapyridine-induced drug rash with eosinophilia and systemic symptoms in Chinese Han population [J]. Pharmacogenomics, 2014, 15(11), 1461–1469.
7. Sijia Yan, HLA-Cw10 is strongly associated with tetanus vaccine and rabies vaccine cutaneous adverse drug reactions, 11th Vaccine Congress, Paradise Point ,San Diego,CA, USA, 17 – 20 September 2017.
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