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个人简介

科研项目: NDRG1在血管损伤后新生内膜形成中的作用及其分子机制 国家自然基金面上项目(81370227) 2014.01—2017.12 65万 甲基苯丙胺(METH)致动脉夹层发生机制及防治 广州科技计划项目(201707010302) 2017.05—2020.04 20万

研究领域

毒品损伤分子机制; 心血管疾病分子机制

近期论文

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Zhu LN, Qiao HH, Chen L, Sun LP, Hui JL, Lian YL, Xie WB, Ding JY, Meng YL, Zhu BF*, Qiu PM*. (2018) SUMOylation of Alpha-Synuclein Influences on Alpha-Synuclein Aggregation Induced by Methamphetamine.Front Cell Neurosci. 24;12:262. [PMID:30197588] Xiao N, Zhang F, Zhu B, Liu C, Lin Z, Wang H*, Xie WB*.(2018) CDK5-mediated Tau accumulation triggers methamphetamine-induced neuronal apoptosis via endoplasmic reticulum-associated degradation pathway. Toxicology Letters, 292:97-107. [PMID:29705343] Xu X, Huang E, Luo B, Cai D, Zhao X, Luo Q, Jin Y, Chen L, Wang Q, Liu C, Lin Z, Xie WB*, Wang H*. (2018) Methamphetamine exposure triggers apoptosis and autophagy in neuronal cells through activating C/EBPβ related signaling pathway. The FASEB Journal, in press, [PMID:29939784] Li L, Chen S, Wang Y, Yue X, Xu J, Xie WB, Qiu P, Liu C, Wang A*, Wang H*. (2017) Role of GSK3β/α-synuclein axis in methamphetamine-induced neurotoxicity in PC12 cells. Toxicol Res (Camb). 7(2):221-234. [PMID:30090577] Du SH, Qiao DF, Chen CX, Chen S, Liu C, Lin Z, Wang H*, Xie WB*. (2017)Toll-like receptor 4 mediates methamphetamine-induced neuroinflammation through Caspase-11 signaling pathway in astrocytes. Frontiers in Molecular Neuroscience, 10:409. [PMID:29311802] Xu X, Huang E, Tai Y, Zhao X, Chen X, Chen C, Chen R, Liu C, Lin Z, Wang H*, Xie WB*. (2017) Nupr1 modulates methamphetamine-induced dopaminergic neuronal apoptosis and autophagy through CHOP-Trib3-mediated endoplasmic reticulum stress signaling pathway. Frontiers in Molecular Neuroscience, 10:203. [PMID: 28694771] Li B, Chen R, Chen L, Qiu P, Ai X, Huang E, Huang W, Chen C, Liu C, Lin Z, Xie WB*, Wang H*. (2017) Effects of DDIT4 in methamphetamine-induced autophagy and apoptosis in dopaminergic neurons. Molecular Neurobiology, 54:1642-1660. [PMID: 26873849] Cai D, Huang E, Luo B, Yang Y, Zhang F, Liu C, Lin Z, Xie WB*, Wang H*. (2016). Nupr1/Chop signal axis is involved in mitochondrion-related endothelial cell apoptosis induced by methamphetamine. Cell Death and Disease, 7:e2161. [PMID: 27031958] Chen R, Wang B, Chen L, Chen C, Huang E, Liu C, Lin Z, Xie WB*, Wang H*. (2016). DNA damage-inducible transcript 4 (DDIT4) mediates methamphetamine-induced autophagy and apoptosis through mTOR signaling pathway in cardiomyocytes. Toxicology and Applied Pharmacology, 295:1-11. [PMID: 26825372] Chen C, Qincao L, Xu J, Du S, Huang E, Liu C, Lin Z, Xie WB*, Wang H*. (2016). Role of PUMA in methamphetamine-induced neuronal apoptosis. Toxicology Letters, 240:149-160. [PMID: 26524635] Hu ZY, Xie WB, Yang F, Xiao LW, Wang XY, Chen SY*, Li ZG*. (2015) NDRG1 attenuates epithelial-mesenchymal transition of nasopharyngeal cancer cells via blocking Smad2 signaling. Biochim Biophys Acta. 1852(9):1876-86. [PMID: 26071641] Huang W, Xie WB, Qiao D, Qiu P, Huang E, Li B, Liu C, Wang Q, Lin Z, Wang H*. (2015)Caspase-11 plays an essential role in methamphetamine-induced dopaminergic neuron apoptosis. Toxicological Sciences, 145:68-79. [PMID: 25631491] Leung KP, Qu YH, Qiao DF, Xie WB, Li DR, Xu JT, Wang HJ*, Yue X*. (2014) Critical role of insulin‑like growth factor binding protein‑5 in methamphetamine‑induced apoptosis in cardiomyocytes.Mol Med Rep. 10(5):2306-12. [PMID:25230843] Qiao D, Xu J, Le C, Huang E, Liu C, Qiu P, Lin Z, Xie WB*, Wang H*. (2014). Insulin-like growth factor binding protein 5 (IGFBP5) mediates methamphetamine-induced dopaminergic neuron apoptosis. Toxicology Letters, 230:444-453. [PMID: 25127757] Wu XF, Wang AF, Chen L, Huang EP, Xie WB, Liu C, Huang WY, Chen CX, Qiu PM*, Wang HJ*.(2014) S-Nitrosylating protein disulphide isomerase mediates α-synuclein aggregation caused by methamphetamine exposure in PC12 cells.Toxicol Lett. 230(1):19-27. [PMID: 25090657] Yang X, Liu Y, Liu C, Xie WB, Huang E, Huang W, Wang J, Chen L, Wang H, Qiu P, Xu J, Zhang F, Wang H*. (2013) Inhibition of ROCK2 expression protects against methamphetamine-induced neurotoxicity in PC12 cells.Brain Res. 1533:16-25. [PMID: 23954743] Xie WB, Li Z, Shi N, Guo X, Tang J, Ju W, Han J, Liu T, Bottinger EP, Chai Y, Jose PA, Chen SY*. (2013) Smad2 and myocardin-related transcription factor B cooperatively regulate vascular smooth muscle differentiation from neural crest cells.Circ Res. 113(8):e76-86. [PMID: 23817199] Shi N, Xie WB, Chen SY*. (2012) Cell division cycle 7 is a novel regulator of transforming growth factor-β-induced smooth muscle cell differentiation. J Biol Chem. 287(9):6860-7. [PMID: 22223649] Huang WY, Xie WB, Guo X, Li F, Jose PA, Chen SY*. (2011) Smad2 and PEA3 cooperatively regulate transcription of response gene to complement 32 in TGF-β-induced smooth muscle cell differentiation of neural crest cells.Am J Physiol Cell Physiol. 301(2):C499-506. [PMID: 21613609] Li Z, Xie WB, Escano CS, Asico LD, Xie Q, Jose PA, Chen SY*. (2011) Response gene to complement 32 is essential for fibroblast activation in renal fibrosis.J Biol Chem. 286(48):41323-30. [PMID: 21990365] Wang JN, Shi N, Xie WB, Guo X, Chen SY*. (2011) Response gene to complement 32 promotes vascular lesion formation through stimulation of smooth muscle cell proliferation and migration.Arterioscler Thromb Vasc Biol. 31(8):e19-26. Xie WB, Li Z, Miano JM, Long X, Chen SY*. (2011) Smad3-mediated myocardin silencing: a novel mechanism governing the initiation of smooth muscle differentiation.J Biol Chem. 286(17):15050-7. [PMID: 21402709]

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