梁重阳 - 吉林大学

个人简介

教育背景 2004-09到2009-07 吉林大学生物化学与分子生物学专业博士学位 2000-09到2004-07 东北林业大学生物技术专业学士学位工作经历 2009-09-至今吉林大学药学院副教授，博士生导师

研究领域

1. 超高通量靶向药物筛选与分子垂钓技术利用微纳分子组装联合拉曼光谱技术开发新型高通量药物筛选方法，针对癌症、糖尿病、高血脂适应症建立了十多个靶向筛选平台，同时将高通量药物筛选技术方法推广应用于各类化合物库，如天然产物分子库、组合化学分子库等，用于各个不同领域分子库的快速药物垂钓筛选，可实现快速、灵敏且高通量筛选的技术能力。 2. 基于基因编辑的现场快速检测技术利用Cas12a、Cas13a和dCas9等基因编辑元件与电化学、单分子催化和光学等多种传感技术相结合，开发新型非扩增核酸现场快速检测技术。 3. 空间转录组技术开发能够达到单细胞和亚细胞分辨率的空间转录组技术，将生物学图案与基因组信息融合分析，这些开发的新技术有助于在时空角度理解并解释发育、肿瘤生物学机制。 4. 新型测序技术研究当前测序技术中的复杂DNA与DNA酶互作体系，开发高效的DNA测序用酶体系，等温测序酶体系。

近期论文

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Dan Sun, Weiqing Xu, Chongyang Liang*, Wei Shi and Shuping Xu*. Smart Surface-Enhanced Resonance Raman Scattering Nanoprobe for Monitoring Cellular Alkaline Phosphatase Activity during Osteogenic Differentiation[J]. ACS Sensors, 2020, 5(6):1758-1767. 一区（IF: 7.333） Jing Yue, Yanting Shen, Lijia Liang, Xin Guan, Xue Zhang, Shuping Xu*, Chongyang Liang*, Wei Shi and Weiqing Xu. Tracing the molecular dynamics of living mitochondria under phototherapy via surface-enhanced Raman scattering spectroscopy[J]. The Analyst, 2019, 144. 二区（IF: 3.978） Jing Yue, Lijia Liang, Yanting Shen, Xin Guan, Jing Zhang, Zhiyuan Li, Rong Deng, Shuping Xu, Chongyang Liang*, Wei Shi and Weiqing Xu*. Investigating Dynamic Molecular Events in Melanoma Cell Nucleus During Photodynamic Therapy by SERS. Front Chem. 2019 Jan 28;6:665. 二区（IF: 3.693） Rong Deng, Jing Yue, Huixin Qu, Lijia Liang, Dan Sun, Jing Zhang, Chongyang Liang*, Weiqing Xu and Shuping Xu*. Glucose-bridged silver nanoparticle assemblies for highly sensitive molecular recognition of sialic acid on cancer cells via surface-enhanced raman scattering spectroscopy[J]. Talanta, 2018, 179:200-206. 二区 (IF: 5.339) Yanting Shen, Shuping Xu*, Chongyang Liang*, et al. Organelle-targeting surface-enhanced Raman scattering (SERS) nanosensors for subcellular pH sensing[J]. Nanoscale, 2018, 10(4): 1622-1630. 一区 (IF: 6.895) Yanting Shen, Shuping Xu*, Chongyang Liang*, et al. Organelle-Targeting Gold Nanorods for Macromolecular Profiling of Subcellular Organelles and Enhanced Cancer Cell Killing[J]. ACS Applied Materials & Interfaces, 2018, 10(9): 7910-7918. 一区 (IF: 8.758) Jing Zhang, Shuping Xu*, Chongyang Liang*, et al. In situ, accurate, surface-enhanced Raman scattering detection of cancer cell nucleus with synchronous location by an alkyne-labeled biomolecular probe[J]. Analytical & Bioanalytical Chemistry, 2018, 410(2): 585-594. 三区 (IF: 3.637) Jing Jin, Fei Sun, Shuping Xu*, Chongyang Liang*, et al. In situ exploration of characteristics of macropinocytosis and size range of internalized substances in cells by 3D-structured illumination microscopy[J]. International journal of nanomedicine, 2018, 13: 5321. 二区 (IF: 5.115) Lijia Liang, Shuping Xu*, Chongyang Liang*, et al. Tracing sialoglycans on cell membrane via surface-enhanced Raman scattering spectroscopy with a phenylboronic acid-based nanosensor in molecular recognition[J]. Biosensors & Bioelectronics, 2017, 94: 148. 一区 (IF:10.257) Rong Deng, Shuping Xu*, Chongyang Liang*, et al. Tracing the Therapeutic Process of Targeted Aptamer/Drug Conjugate on Cancer Cells by Surface-Enhanced Raman Scattering Spectroscopy[J]. Analytical Chemistry, 2017, 89(5): 2844. 一区 (IF: 6.785) Lu Dai，Weikang Li，Fei Sun，Baizhi Li，Hongrui Li，Hongxing Zhang*，Qingchuan Zheng*，Chongyang Liang*. A strategy of designing the ligand of antibody affinity chromatography based on molecular dynamics simulation[J]. Journal of Chromatography A，2016，1463:81-89. 二区（IF: 4.049） Lijia Liang, Chongyang Liang*, Weiqing Xu*, et al. In Situ Surface-Enhanced Raman Scattering Spectroscopy Exploring Molecular Changes of Drug-Treated Cancer Cell Nucleus[J]. Analytical Chemistry, 2015, 87(4): 2504. 一区. (IF: 6.785)