赵庆顺 - 南京大学 - 模式动物研究所

个人简介

1987年本科毕业于南京大学，获学士学位；1990年硕士研究生毕业于南京大学，获硕士学位；2001年博士研究生毕业于普度大学（Purdue University, West Lafayette, IN, USA），获博士学位。博士毕业论文在Paul Collodi教授指导下完成，聚焦于斑马鱼发育过程中纤连蛋白各种异型体的鉴定和表征。2001-2003年在杜克大学医学中心（Duke University Medical Center）Elwood Linney教授指导下进行博士后训练，从事视黄酸信号在斑马鱼后脑发育中作用及机制的研究。2003年全职加入南京大学模式动物研究，任副教授和PI；2006年晋升为教授。基金种类基金项目名称高等学校博士学科点专项科研基金　20130091110051　foxc1a通过作用于视黄酸信号上游调控斑马鱼体节发生的分子机制研究国家自然科学基金　　31271569　视黄酸信号抑制斑马鱼原始髓性细胞发生的分子机制研究国家自然科学基金　31471355　原肠早期视黄酸效应基因在斑马鱼后脑发生中的作用及机制研究

研究领域

1.以模式动物斑马鱼为研究对象，运用基因组改造手段(转基因和基因敲除)，研究遗传和环境因素调控脊椎动物胚胎早期发育包括胚层形成和分化、胚胎体轴建立及心血管发生的分子机制。 2.以土著水产经济动物黄颡鱼为研究对象，通过实验动物化研究，建立代表我国土著水生脊椎动物的模式动物体系；运用基因组改造手段(转基因和基因敲除)，开展经济水生动物的分子辅助育种研究。

近期论文

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1. Yunyun Yue, Mingyang Jiang, Luqingqing He, Zhaojunjie Zhang, Qinxin Zhang, Chun Gu, Meijing Liu, Nan Li, Qingshun Zhao*. 2018. The transcription factor Foxc1a in zebrafish directly regulates expression of nkx2.5, encoding a transcriptional regulator of cardiac progenitor cells. The Journal of Biological Chemistry, 293(2):638-650. 2. Li Zhou, Yongyong Feng, Fang Wang, Xiaohua Dong, Lan Jiang, Chun Liu, Qinshun Zhao**, Kaibin Li*. 2018. Generation of all-male-like sterile zebrafish by eliminating primordial germ cells at early development. Scientific Reports. 8(1):1834. doi: 10.1038/s41598-018-20039-3. 3. Dong XH, Li JY, He LQQ, Gu C, Jia WS, Yue YY, Li J, Zhang QX, Chu LL, Qingshun Zhao (2017) Zebrafish Znfl1 proteins control the expression of hoxb1b gene in the posterior neuroectoderm by acting upstream of pou5f3 and sall4 genes. Journal of Biological Chemistry 292: 13045-13055. 4. Gong J, Wang X, Zhu CW, Dong XH, Zhang QX, Wang XN, Duan XC, Qian FP, Shi YW, Gao Y, Qingshun Zhao, Chai RJ, Liu D (2017) Insm1a Regulates Motor Neuron Development in Zebrafish. Frontiers in Molecular Neuroscience 10: 274. 5. Shu Xu, Shasha Cao, Bingjie Zou, Yunyun Yue, Chun Gu, Xin Chen, Pei Wang, Xiaohua Dong, Zheng Xiang, Kai Li, Minsheng Zhu**, Qingshun Zhao**, Guohua Zhou*. (2016) An alternative novel tool for DNA editing without target sequence limitation: the structure-guided nuclease. Genome Biology. 17(1):186. doi: 10.1186/s13059-016-1038-5. 6. Junbo Li, Yunyun Yue, Qingshun Zhao*. 2016. Retinoic acid signaling is essential for valvulogenesis by affecting endocardial cushions formation in zebrafish embryos. Zebrafish, 13(1):9-18. (Cover) 7. Jingyun Li, Yunyun Yue, Xiaohua Dong, Wenshuang Jia, Kui Li, Dong Liang, Zhangji Dong, Xiaoxiao Wang, Xiaoxi Nan, Qinxin Zhang, Qingshun Zhao*. 2015. Zebrafish foxc1a plays a crucial role in early somitogenesis by restricting the expression of aldh1a2 directly. The Journal of Biological Chemistry, 290(16):10216-28. 8. Zhangji Dong, Xiaohua Dong, Wenshang Jia, Shasha Cao, Qingshun Zhao*. 2014. Improving the efficiency for generation of genome-edited zebrafish by labelling primordial germ cells. The International Journal of Biochemistry & Cell Biology, 55:329-34. 9. Jingyun Li, Kui Li, Xiaohua Dong, Dong Liang, Qingshun Zhao*. 2014. Ncor1 and Ncor2 play essential but distinct roles in zebrafish primitive myelopoiesis. Developmental Dynamics, 243(12):1544-1553. 10. Junbo Li, Wenshuang Jia, Qingshun Zhao*. 2014. Nitrite affects zebrafish valvulogenesis through yielding too much NO signalling. PLoS ONE, 9(3):e92728. 11. Zhangji Dong, Jiachun Ge, Zhiqiang Xu, Xiaohua Dong, Shasha Cao, Jianlin Pan, Qingshun Zhao*. 2014. Generation of myostatin b knock out yellow catfish (Tachysurus fulvidraco) using transcription activator-like effector nucleases. Zebrafish, 11(3):265-74. 12. Ting Xu, Jing Zhao, Ping Hu, Zhangji Dong, Jingyun Li, Hongchang Zhang, Daqiang Yin*, Qingshun Zhao**. 2014. Pentachlorophenol exposure causes Warburg-like effects in zebrafish embryos at gastrulation stage. Toxicology and Applied Pharmacology, 277(2):183-91. 13. Dong Liang, Wenshuang Jia, Jingyun Li, Kui Li, Qingshun Zhao*. 2012. Retinoic acid signalling plays a restrictive role in zebrafish primitive myelopoiesis. PLoS ONE, 7(2): e30865. 14. Jiachun Ge, Zhangji Dong, Jingyun Li, Zhiqiang Xu, Wei Song, Jie Bao, Dong Liang, Junbo Li, Kui Li, Wenshuang Jia, Muzi Zhao, Yongxiang Cai, Jiaxin Yang, Jianlin Pan, Qingshun Zhao*. 2012. Isolation of yellow catfish b-actin promoter and generation of transgenic yellow catfish expressing enhanced yellow fluorescent protein. Transgenic Research, 21(5):995-1004. 15. Jingyun Li, Ping Hu, Kui Li, Qingshun Zhao*. 2012. Identification and characterization of a novel retinoic acid response element in zebrafish cyp26a1 promoter. The Anatomical Record, 295:268-277. 16. Zhangji Dong, Jiachun Ge, Kui Li, Zhiqiang Xu, Dong Liang, Jingyun Li, Junbo Li, Wenshuang Jia, Yuehau Li, Xiaohua Dong, Shasha Cao, Xiaoxiao Wang, Jianlin Pan, Qingshun Zhao*. 2011. Heritable targeted inactivation of myostatin gene in yellow catfish (Pelteobagrus fulvidraco) using engineered zinc finger nucleases. PLoS ONE, 6(12):e28897. 17. Fang Xu, Kui Li, Miao Tian, Ping Hu, Wei Song, Jiong Chen, Xiang Gao, Qingshun Zhao*. 2009. N-CoR is required for patterning the anterior–posterior axis of zebrafish hindbrain by actively repressing retinoid signaling. Mechanism of Development, 126:771-780. 18. Daqiang Yin, Hankai Zhu, Ping Hu, Qingshun Zhao*. 2009. Genotoxic effect of 2,4,6-trichlorophenol on p53 gene in zebrafish liver. Environmental Toxicology and Chemistry, 28(3): 603–608. 19. Ping Hu, Miao Tian, Jie Bao, Guangdong Xing, Xingxing Gu, Xiang Gao, Elwood Linney, Qingshun Zhao*. 2008. Retinoid regulation of the zebrafish cyp26a1 promoter. Developmental Dynamics, 237:3798-3808. 20. Dong Liang, Mei Zhang, Jie Bao, Luqing Zhang, Xiaofeng Xu, Xiang Gao, Qingshun Zhao*. 2008. Expressions of Raldh3 and Raldh4 during zebrafish early development. Gene Expression Patterns, 8(4): 248-253. 21. Jianlin Pan, Xiaolin Wang, Wei Song, Jianxiu Chen, Caojun Li, Qingshun Zhao*. 2007. Molecular cloning and expression pattern of myostatin gene in yellow catfish (Pelteobagrus fulvidraco). DNA Sequence, 18 (4): 279-287. 22. Xingxing Gu, Fang Xu, Wei Song, Xiaolin Wang, Ping Hu, Yumin Yang, Xiang Gao, Qingshun Zhao*. 2006. A novel cytochrome P450, zebrafish Cyp26D1, is involved in metabolism of all-trans retinoic acid. Molecular Endocrinology, 20(7):1661-1672. 23. Daqiang Yin, Ying Gu, Yan Li, Xiaolin Wang, Qingshun Zhao*. 2006. Pentachlorophenol treatment in vivo elevates point mutation rate in zebrafish p53 gene. Mutation Research - Genetic Toxicology and Environmental Mutagenesis, 609:92-101. 24. Wei Song, Zhiying Zou, Fang Xu, Xingxing Gu, Xiaofeng Xu, Qingshun Zhao*. 2006. Molecular cloning and expression of a second zebrafish aldehyde dehydrogenase 2 gene (aldh2b). DNA Sequence, 17(4):262-269. 25. Lu Sun, Zhiying Zou, Paul Collodi, Fang Xu, Xiaofeng Xu, Qingshun Zhao*. 2005. Identification and characterization of a second fibronectin gene in zebrafish. Matrix Biology, 24(1): 69-77. 26. Xingxing Gu, Fang Xu, Xiaolin Wang, Xiang Gao, Qingshun Zhao*. 2005. Molecular cloning and expression of a novel CYP26 gene (cyp26d1) during zebrafish early development. Gene Expression Patterns, 5(6):733-739. .