个人简介
Chunmao received his B.S. in Pharmaceutical Engineering from the Taiyuan University of Technology in 2005, and later a Master degree in Organic Chemistry from the Guangzhou Institute of Chemistry (CAS) in 2008. He received his Ph.D. in Bioinorganic Chemistry from the Max Planck Institute for Chemical Energy Conversion (formerly MPI Bioinorganic Chemistry), working on the understanding of the fundamentals in heme protein catalysis, under the direction of Prof. Wolfgang Lubitz. He used a variety of biophysical techniques including UV-vis, Raman and EPR. In 2013, he moved to the; laboratory of Prof. Jeffrey Bode at ETH Zurich (also ITbM, Nagoya University) to learn peptide synthesis and ligation techniques as a postdoc. Since Aug. 2016, he joined the faculty of the School of Chemistry and Chemical Engineering, SCUT, as a full Professor.
Selected Awards
2018 Pearl River Recruitment Program of Talents
研究领域
Our research, powered by our expertise in protein manipulation either recombinantly or chemically, centers on the development of artificial metalloproteins that are highly relevant for small (but reactive) gaseous molecule storage/transportation and sustainable catalysis. We are combining a number of key techniques from molecular biology to protein chemical synthesis to spectroscopy.
近期论文
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S. Lin; Z. Mo; P. Wang; C. He*. Oxidation and Phenolysis of Peptide/Protein C-Terminal Hydrazides Afford Salicylaldehyde Ester Surrogates for Chemical Protein Synthesis. J. Am. Chem. Soc. 2023, Accepted Article. (10.1021/jacs.3c05190)
Y. Chen#; Y. Zhou#; C. He*. Insertion of unnatural metal ligand in the heme pocket of nitrophorin through protein semi-synthesis: toward biomimicking binuclear active sites. Chin. Chem. Lett., 2023, Accepted Article. (#equal contribution) (10.1016/j.cclet.2023.108251)
Z. Mo; Z. Xiao; C. He*. Functional expression of a thrombin exosite I inhibitor triabin in Escherichia coli and elucidation of the role of key residues in its inhibitory activity. Biochimie, 2023, 208, 13–19. (10.1016/j.biochi.2022.12.013)
S. Huang; W-H. Deng; R-Z. Liao* and C. He*. Repurposing a Nitric Oxide Transport Hemoprotein Nitrophorin 2 for Olefin Cyclopropanation. ACS Catal., 2022, 12(21), 13725–13731 (10.1021/acscatal.2c03515)
Y. Zhou; Y. Sun; K. Yi; Z. Wang; Y. Liu and C. He*. Solid-phase synthesis of peptides with azopyridine side-chains for Mn(i)–CO binding and red-light responsive CO release. Inorg. Chem. Front., 2022, 9(22), 5941–5949 (10.1039/D2QI01653B)
Y. Yang; M. Liang; R. Wang; Z. Wang* and C. He*. key modulation mechanism of the tyrosine-O-sulfation in inducing strengthened inhibitory activity of hirudin. Chin. Chem. Lett., 2022, 34(5), 107806. (10.1016/j.cclet.2022.107806)
P. Liao; H. Liu* and C. He*. Chemical Synthesis of Human Selenoprotein F and Elucidation of Its Thiol-Disulfide Oxidoreductase Activity. ChemRxiv, 2022. (10.26434/chemrxiv-2022-j6nwl)
Z. Mo; S. Lin; W. Chen and C. He*. Protein Ligation and Labeling Enabled by a C-Terminal Tetracysteine Tag. Angew. Chem. Int. Ed., 2022, Accepted Article. (10.1002/anie.202115377)
P. Liao and C. He*. Chemical Synthesis of the Sec-To-Cys Homologue of Human Selenoprotein F and Elucidation of Its Disulfide-pairing Mode. Front. Chem., 2021, 9, 735149. (10.3389/fchem.2021.735149)
Y. Zhang#; J. Chen# and C. He*. On Demand Attachment and Detachment of rac-2-Br-DMNPA Tailoring to Facilitate Chemical Protein Synthesis. Org. Lett., 2021, 23, 6477-6481. (10.1021/acs.orglett.1c02295)
S. Lin and C. He*. Development of Nonheme {FeNO}7 Complexes Based on the Pyrococcus furiosus Rubredoxin for Red-Light-Controllable Nitric Oxide Release. Inorg. Chem., 2021, 60, 14364-14370. (10.1021/acs.inorgchem.1c02089)
Y. Zhou#; Y. Chen# and C. He*. Solid-phase synthesis of peptide Mn(I)–carbonyl bioconjugates and their CO release upon visible light activation. Dalton Trans., 2021, Advance Article. (#equal contribution) (10.1039/D1DT00395J)
S. Lin; C. He*. Streamlined purification and characterization of Pyrococcus furiosus rubredoxins with different N-terminal modifications by reversed-phase HPLC. Anal. Biochem., 2021, 619, 114128. (10.1016/j.ab.2021.114128)
C. Li; C. He*. Facile synthesis of the sulfotyrosine-containing α-Conotoxins. Org. Biomol. Chem., 2020, Accepted Manuscript. (10.1039/D0OB01526A)
Y. Zhou; C. He*. Functional expression and purification of the untagged C-terminal domain of MMP-2 from Escherichia coli inclusion bodies. Protein Expr. Purif., 2020, 176, 105726. (10.1016/j.pep.2020.105726)
S. Lin; C. He*. A mini-review on the enzyme-mediated manipulation of proteins/peptides. Chin. Chem. Lett., 2018, 29, 1017–1021. (10.1016/j.cclet.2018.05.006)
C. He*; H. Ogata; W. Lubitz*. Elucidation of the heme active site electronic structure affecting the unprecedented nitrite dismutase activity of the ferriheme b proteins, the nitrophorins. Chem. Sci., 2016, 7, 5332–5340.
C. He; S.S. Kulkarni; F. Thuaud; J.W. Bode. Chemical synthesis of the 20 kDa heme protein nitrophorin 4 by α-ketoacid hydroxylamine (KAHA) ligation. Angew. Chem. Int. Ed. 2015, 54, 12996–13001.
C. He *; B.D. Howes; G. Smulevich; S. Rumpel; E.J. Reijerse; W. Lubitz*; N. Cox*; M. Knipp. Nitrite Dismutase reaction mechanism: Kinetic and spectroscopic investigation of the interaction between.
C. He; K. Nishikawa; O.F. Erdem; E. Reijerse; H. Ogata; W. Lubitz; M.Knipp. Complexes of ferriheme nitrophorin 4 with low-molecular weight thiol(ate)s occurring in blood plasma. J. Inorg. Biochem. 2013, 122, 38–48.
S. Abbruzzetti; C. He; H. Ogata; S. Bruno; C. Viappiani; M. Knipp.Heterogeneous kinetics of the carbon monoxide association and dissociation reaction to nitrophorin 4 and 7 coincide with structural heterogeneity of the gate-loop. J. Am. Chem. Soc. 2012, 134, 9986–9998.
M. Knipp; J. J. Taing; C. He; C. Viappiani. A caged cyanide. Photochem. Photobiol. Sci. 2012, 11, 620–622.
C. He H. Ogata; M. Knipp. Insertion of an H-bonding residue into the distal pocket of the ferriheme protein nitrophorin 4: Effect on nitrite–iron coordination and nitrite disproportionation. Chem. Biodivers. 2012, 9, 1761–1775. (Special Issue: Bioinorganic Chemistry-ICBIC XV)
C. He; M. Fuchs; H. Ogata; M. Knipp. Guanidine–ferroheme coordination in the mutant protein Nitrophorin 4 (L130R). Angew. Chem. Int. Ed. 2012, 51, 4470–4473.
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