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个人简介

讲授课程《病毒学》、《人畜共患病》 现为农业微生物学国家重点实验室固定研究人员,教育部“动物传染病基础与防治技术研究”创新研究群体成员,湖北省“农业动植物病虫害防治的微生物学研究”优秀创新团队骨干成员,中国畜牧兽医学会兽医公共卫生学分会实验室生物安全委员会委员。 主要从事病毒学和人畜共患病教学、科研和科技开发工作。研究领域为α疱疹病毒(伪狂犬病毒、牛疱疹病毒1/5型)的嗜神经性和潜伏感染性机制,以及布鲁氏菌的胞内寄生和致病机制,并研制新型疫苗与分子诊断试剂盒。目前主持和承担国家自然科学基金等国家课题3项。在Journal of Investigative Dermatology、Journal of Virology、Vaccine、《微生物学报》等国内外刊物上发表论文30篇;获发明专利5项。荣获湖北省科技进步一等奖1项,华中农业大学教学质量优秀奖5项,优秀学位论文指导奖9项。培养毕业研究生22人,均成长为国家事业单位和大型企业单位青年骨干。 教育经历 1997.09 - 2002.06, 华中农业大学,兽医专业毕业,农学博士 1993.09 - 1997.06, 华中农业大学,畜牧专业毕业,农学学士 工作经历 2011.12-至今,华中农业大学动物医学院教授、博士生导师。 2004.12-2011.11,华中农业大学副教授。 2004.10-2007.4,美国堪萨斯州立大学(Kansas State University)兽医学院博士后。 2002.7-2004.11,华中农业大学讲师。 著作类(近五年) 参编《农业高效实验室技术安全知识题库》,中国农业出版社,2012。 科研项目 1. 2017.02国家自然科学基金面上项目“伪狂犬病毒lncRNA(CTO)对病毒复制和潜伏感染的调控作用研究”(编号:31770191),直接经费65万,2018.1-2021.12 2. 湖北省技术创新专项重大项目“家畜重要人畜共患病诊断试剂和新型疫苗研制”(编号:2016ABA124),100万,2016.5-2019.4 3. 国家重点研发计划“新发与再现畜禽重大疫病的致病与免疫机制研究”课题5“猪伪狂犬病毒潜伏感染及其致病机制”(编号:2016YFD0500105),625万,2016.7-2020.12 4. 国家自然科学基金面上项目“Bhv5-miR-B10对BoHV-5沿嗅神经通路侵入大脑的调控作用研究”(编号:31470259),82万,2015.1-2018.12 主要奖励 1. 获授权发明专利6项。 2. 获湖北省科技进步一等奖1项。 3. 优秀研究生论文指导奖5项。 4. 教学质量优秀奖5项。

研究领域

动物传染病和人畜共患病

近期论文

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Wu Chang-Xian, Liu Zheng-Fei*. Proteomic profiling of sweat exosome suggests its involvement in skin immunity. Journal of Investigative Dermatology. 2017 Sep 9. pii: S0022-202X(17)32931-7. doi: 10.1016/j.jid.2017.05.040. [Epub ahead of print] (IF= 6.287) Wang Xin, Wu Chang-Xian, Song Xian-Rong, Chen Huan-Chun, Liu Zheng-Fei *. Comparison of pseudorabies virus China reference strain with emerging variants reveals independent virus evolution within specific geographic regions. Virology. 2017, 506: 92-98 (IF= 3.353) Ahmed Waqas, Zheng Keng and Liu Zheng-Fei*. Small non-coding RNAs: new insights in modulation of host immune response by intracellular bacterial pathogens. Frontiers in Immunology (Front. Immunol.) 2016, 7:431. doi: 10.3389/fimmu.2016.00431 (IF= 6.429) Ahmed Waqas, Zheng Ke and Liu Zheng-Fei*. Establishment of chronic infection: Brucella’s stealth strategy. Frontiers in Cellular and Infection Microbiology (Front Cell Infect Microbiol). 2016, 6: 30 doi: 10.3389/fcimb.2016.00030 (IF=4.3) Wu Chang-Xian, Xu Xian-Jin, Zheng Ke, Liu Fang, Yang Xu-Dong, Chen Chuang-Fu, Chen Huan-Chun, Liu Zheng-Fei*. Characterization of ribonuclease III from Brucella. Gene. 2016, 579(2): 183-192 (IF=2.415) Hu Rui-Ming, Zhou Qing, Song Wen-Bo, Sun Er-Chao, Zhang Mei-Mei, He Qi-Gai, Chen Huan-Chun, Wu Bin*, Liu Zheng-Fei*. Novel pseudorabies virus variant with defects in TK, gE and gI protects growing pigs against lethal challenge. Vaccine. 2015, 33(43): 5733-5740. (IF=3.624) Yao Lan, Wu Chang-Xian, Zheng Ke, Xu Xian-Jin, Zhang Hui, Chen Chuang-Fu, Liu Zheng-Fei*. Immunogenic response to a recombinant pseudorabies virus carrying bp26 gene of Brucella melitensis in mice. Research in Veterinary Science. 2015, 100: 61-67. (IF=1.511) Tang Qi , Wu Yi-Quan, Chen Dong-Sheng, Zhou Qing, Chen Huan-Chun, and Liu Zheng-Fei*. Bovine herpesvirus 5 encodes a unique pattern of microRNAs compared with Bovine herpesvirus 1. Journal of General Virology. 2014,95(3): 671-678. (IF=3.527) Fan Qiang, Yao Lan, Ding Ming, Wang Dan-Jing, Chen Huan-Chun, and Liu Zheng-Fei*. Development of latex agglutination test for rapid detection of antibodies against Bovine herpesvirus 1 and Bovine herpesvirus 5 in cattle. Journal of Veterinary Diagnostic Investigation (J VET Diagn Invest). 2012, 24(6): 1162-1165. (IF= 1.214) Zheng Ke, Chen Dong-Sheng, Wu Yi-Quan, Xu Xian-Jin, Zhang Hui, Chen Chuang-Fu, Chen Huan-Chun, Liu Zheng-Fei*. MicroRNA expression profile in RAW264.7 cells in response to Brucella melitensis infection. International Journal of Biological Sciences (Int J Biol Sci). 2012; 8(7): 1013- 1022. (IF= 3.168) Wu Yi-Quan, Chen Di-Jun, He Hua-Bin, Chen Dong-Sheng, Chen Ling-Ling, Chen Huan-Chun, Liu Zheng-Fei*. Pseudorabies virus infected porcine epithelial cell line generates a diverse set of host microRNAs and a special cluster of viral microRNAs. PLoS ONE. 2012, 7(1): e30988. doi:10.1371/journal.pone.0030988. (IF= 4.411) Zhang Hou–Yong , Chen Dong–Sheng, Wu Yi–Quan, He Qi–Gai, Chen Huan–Chun, and Liu Zheng–Fei*. Both swine and human cells are capable to support the replication of swine hepatitis E virus type 4 in vitro. Virus Research. 2011, 158: 289-293. (IF= 2.905) 尹贻鑫,何宁宇,张瑞竹,张炜,陈兴江,陈焕春,刘正飞*. 牛疱疹病毒1型复制非必需基因UL0.5的鉴定. 中国预防兽医学报. 2013, 11: 865-869

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