个人简介
英国Reading University博士后，教育部新世纪优秀人才。
一、所获奖项
教育部新世纪优秀人才、海洋科学技术奖、国家海洋局海洋创新成果奖、高等学校科学研究优秀成果奖、山东省科学技术进步奖，山东省技术发明奖、山东省普通高等学校省级优秀实验技术成果奖、山东省优秀博士学位论文、山东省研究生优秀科技创新成果指导奖、青岛市科学技术发明奖、山东省优秀硕士学位论文指导奖、山东省专业学位研究生优秀实践成果指导奖等。
二、科研情况
发表论文140余篇，其中SCI/EI 收录74篇；申请国家专利49项，国际PCT专利2项，授权11项。
（一）主持科研项目：
1、国家自然科学基金“海洋噬菌体及其聚糖降解酶的研究”；
2、国家自然科学基金“海洋硫酸半乳低聚糖的酶法制备与抗病毒活性分析”；
3、国家自然科学基金“利用海洋细菌胞外多糖制备空肠弯曲菌粘附受体模拟寡糖”；
4、国家自然科学基金“噬菌体源聚糖酶的异源表达及其对海洋岩藻糖基聚糖的多靶点催化机制研究”；
5、国家重点研发计划“蓝色粮仓科技创新”专项“杀菌品质保障技术与智能控制装备研发”课题；
6、国家重点研发计划“水产品全链条关键危害物的迁移转化规律与安全防控技术研究”子课题；
7、山东省重点研发计划特医食品专项“肠道代谢综合调节型低聚糖的功能强化与高效定向制备技术”；
8、山东省自然科学基金“海洋细菌Microbulbifer sp. Q7海洋多糖降解酶的研究”；
9、山东省中青年科学家科研奖励基金“抗病毒活性海洋硫酸低聚糖的酶法制备”；
10、山东省科技攻关计划“农药广谱降解菌的高通量筛选与土壤原位生物修复”；
11、国家海洋局海洋公益性行业科研专项“经济褐藻新资源开发、养护和高值化利用关键技术研究与应用”；
12、中央高校基本科研业务费基础性工作专项“海洋特征酶菌种资源及功能基因的调查与功能研究”。
（二）目前开展的主要工作：
1、海洋微生物功能酶与功能基因的发现与挖掘；
2、功能低聚糖制备的生物技术研究及其生物学活性评价；
3、海洋资源高值化生物转化技术研究。
三、教学情况
（一）所开设课程：
“微生物学”（本科生）、“海洋微生物工程”（本科生）；“食品生物学基础与工程前沿”（研究生）。
（二）编写教材专著：
1. 海洋微生物工程，主编，ISBN 978-7-5670-1112-0
2. 全国农业推广专业学位研究生教育指导委员会推荐教材《食品原料生产安全控制技术》，副主编
3. 国家攀登计划B专著《海水养殖动物的免疫、细胞培养和病害研究》，参编
4. 全国高等农林院校“十一五”规划教材《食品微生物检验技术》，参编
近期论文
查看导师最新文章
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1. Composition and characteristics of continuous enzymatic hydrolysis products from Kappaphycus striatum. Journal of Applied Phycology, 2017, DOI: 10.1007/s10811-017-1064-z
2. Characterization of lipopeptide biosurfactants produced by Bacillus licheniformis MB01 from marine sediments, Frontiers in Microbiology, 2017, 8, doi: 10.3389/fmicb.2017.00871
3. Genomic analysis of Microbulbifer sp. Q7 exhibiting degradation activity toward seaweed polysaccharides. Marine Genomics. 2017, http://dx.doi.org/10.1016/j.margen.2017.07.003
4. Characterization of full-length and truncated recombinant κ-carrageenase expressed in Pichia pastoris. Frontiers in Microbiology, 2017, 15. https://doi.org/10.3389/fmicb.2017.01544
5. Extracellular expression of a novel β-agarase from Microbulbifer sp. Q7, isolated from the gut of sea cucumber, AMB Express, 2017. https://doi.org/10.1186/s13568-017-0525-8
6. Expression and characterization of a new polyG-specific alginate lyase from marine bacterium Microbulbifer sp. Q7. Frontiers in Microbiology, 2018, DOI: 10.3389/fmicb.2018.02894.
7. Study on the ability of partially hydrolyzed guar gum to modulate the gut microbiota and relieve constipation. Journal of Food Biochemistry, 2018, DOI: 10.1111/jfbc.12715
8. Nondigestible Carbohydrates, Butyrate, and Butyrate-producing Bacteria. Critical Reviews in Food Science and Nutrition, 2018, DOI 10.1080/10408398.2018.1542587
9. Study on expression and action mode of recombinant alginate lyases based on conserved domains reconstruction. Applied Microbiology and Biotechnology. 2018, DOI: 10.1007/s00253-018-9502-7
10. Production of a water-soluble protein powder from anchovy and soybean meal by endogenous enzymatic hydrolysis and solid-state fermentation. Journal of Food Processing and Preservation, 2018 DOI: 10.1111/jfpp.13854
11. Anti-oxidant and anti-inflammatory activities of ultrasonic-assistant extracted polyphenol-rich compounds from Sargassum muticum. Journal of Oceanology and Limnology, IF0.717, 2019, DOI: 10.1007/s00343-019-8138-5
12.Wen Zhang#, Zhemin Liu#, Sijia Zhou, Haijin Mou*, Ruifu Zhang*, Cloning and expression of a β-mannanase gene from Bacillus sp. MK-2 and its directed evolution by random mutagenesis. Enzyme and Microbial Technology, 2019, 124: 70-78.
13. Expression, purification and characterisation of chondroitinase AC II with glyceraldehyde-3-phosphate dehydrogenase tag and chaperone (GroEs-GroEL) from Arthrobacter sp. CS01. International Journal of Biological Macromolecules, 2019, 129: 471–476
14. Flocculation activity of carp protamine in microalgal cells. Aquaculture, 2019, 505: 150-156
15. In-vitro assessment of the effects of alginate, agar and κ-carrageenan oligosaccharide on microbiota fermentation and communities by pig gut microbiota. Marine Drugs, 2019, 17
16. Expression, purification and characterization of chondroitinase AC II from marine bacterium Arthrobacter sp. CS01. Marine Drugs, 2019, 17, 185
17. Improving catalytic efficiency and maximum activity at low pH of Aspergillus neoniger phytase using rational design. International Journal of Biological Macromolecules, 2019, doi.org/10.1016/j.ijbiomac.2019.03.140
18. Purification and characterization of angiotensin I-converting enzyme (ACE) inhibitory peptides with specific structure X-Pro. European Food Research and Technology. 2019, 245(8): 1743-1753
19.Structure and molecular morphology of a novel moisturizing exopolysaccharide produced by Phyllobacterium sp. 921F. International Journal of Biological Macromolecules 2019, 135: 998–1005
20. Rational design of alginate lyase from Microbulbifer sp. Q7 to improve thermal stability. Marine Drugs, 2019, 17, 378
21. Enhancing the expression of recombinant κ-carrageenase in Pichia pastoris using dual promoters, co-expressing chaperones and transcription factors. Biocatalysis and Biotransformation, 2019, DOI: 10.1080/10242422.2019.1655001
22. Eco-friendly preparation of chitooligosaccharides with different degrees of deacetylation from shrimp shell waste and their effects on the germination of wheat seeds. Marine Life Science and Technology, 2019. DOI: 10.1007/s42995-019-00012-3
23. High-level expression of a thermophilic and acidophilic β-mannanase from Aspergillus kawachii IFO 4308 with significant potential in mannooligosaccharide preparation. Bioresource Technology, 2020, 295: 122257
24. Partially degraded chitosan-based flocculation to achieve effective deodorization of oyster (Crassostrea gigas) hydrolysates. Carbohydrate Polymers, 2020, DOI: 10.1016/j.carbpol.2020.115948
25. Bacteriostatic effect of lipopeptides from Bacillus subtilis N-2 on Pseudomonas putida using soybean meal by solid-state fermentation. Marine Life Science & Technology, 2020, DOI: 10.1007/s42995-020-00028-0
26. Enzymatic preparation of low-molecular-weight polysaccharide rich in uronic acid from the seaweed Laminaria japonica and evaluation of its hypolipidemic effect in mice. Food & Function, 2020, 11, 2395 – 2405
27. Properties of hydrolyzed guar gum fermented in vitro with pig fecal inocula and its favorable impacts on microbiota. Carbohydrate Polymers, 2020, 237: 116116
28. High-efficiency expression of a superior β-mannanase engineered by cooperative substitution method in Pichia pastoris and its application in preparation of prebiotic mannooligosaccharides, Bioresource Technology, 2020, https://doi.org/10.1016/j.biortech.2020.123482
29. Dietary galactosyl and mannosyl carbohydrates: In-vitro assessment of prebiotic effects, Food Chemistry, 2020, DOI: 10.1016/j.foodchem.2020.127179
30. Expression and characterization of an alginate lyase and its thermostable mutant in Pichia pastoris. Marine Drugs, 2020, 18(6), 305
31. A thermostable glucose oxidase from Aspergillus heteromophus CBS 117.55 with broad pH stability and digestive enzyme resistance. Protein Expression and Purification, 2020, 176: 105717
学术兼职
中国民间中医医药研究开发协会海洋医学分会副会长、中国农业机械学会农副产品加工分会副主任委员、山东省农业机械学会水产专委会主任委员、全国无抗产业科技创新联盟副理事长、国际期刊《Marine Life Science and Technology》领域主编、《Frontiers in Microbiology》Topic Editor、中国食品药品企业质量安全促进会功能食品分会专家委员、山东省食品科学技术学会常务理事、青岛市食品科学技术学会常务理事等。
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