个人简介
Dr. Xiao Zhi is assistant professor in Institute of Personalized Medicine, Shanghai Jiao Tong University. He majored biomedical engineering and received his Ph.D. degree from Institute of Micro-Nano Science and Technology in Shanghai Jiao Tong University (SJTU) in 2014. His research interests focus on developing personalized theranostics and precision medicine, including: (1) developing biosensors, microfluidic chips and bio-MEMS for early detection of cancer biomarkers, infectious diseases, bacteriotoxins based on electrochemistry, photoelectric signals and giant magnetoresistance (GMR) effect. (2) developing novel nanomaterials for disease theranostics, point of care testing (POCT), drug delivery, gene carriers and immunologic adjuvants. (3) developing imaging mass cytometry (IMC) for clinical medicine and basic biology.
Research Interests: POCT, biosensors, microfluidics, imaging mass cytometry (IMC)
郅晓，助理研究员，2014年毕业于上海交通大学生物医学工程专业，目前主要研究方向为质谱成像技术、微流控芯片、生物传感器、纳米材料和非硅MEMS微加工技术的开发等在即时诊断、超灵敏检测、药物和基因递送、高效免疫佐剂方面的基础与应用研究，相关研究成果发表于ACS Nano、Biomaterials、Lab on a Chip、Biosensors & Bioelectronics、Analytical Chemistry、IEEE Electron Device Letters等国际知名期刊，申请专利9项，获上海市技术发明一等奖一项，参与973项目、863项目、国家重点研发计划项目、卫生部传染病重大专项等重要科研项目。
研究领域
体外诊断、质谱成像技术、生物传感器、微流控芯片、纳米材料
近期论文
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1. Lin S, Xu J, Zhi X, Chen D, Miao J, Shull P B, et al. Design and fabrication of a stretchable circuit board for wireless posture measurement. IEEE Electron Device Letters. 2017; 38: 399-402.
2. Yang M, Liu Y, Hou W, Zhi X, Zhang C, Jiang X, et al. Mitomycin C-treated human-induced pluripotent stem cells as a safe delivery system of gold nanorods for targeted photothermal therapy of gastric cancer. Nanoscale. 2017; 9: 334-40.
3. Hou W, Xia F, Alfranca G, Yan H, Zhi X, Liu Y, et al. Nanoparticles for multi-modality cancer diagnosis: Simple protocol for self-assembly of gold nanoclusters mediated by gadolinium ions. Biomaterials. 2017; 120: 103-14.
4. Liu Y, Zhi X, Yang M, Zhang J, Lin L, Zhao X, et al. Tumor-triggered drug release from calcium carbonate-encapsulated gold nanostars for near-infrared photodynamic/photothermal combination antitumor therapy. Theranostics. 2017; 7: 1650-62.
5. Chang J, Zhi X*, Zhang A. Application of graphene in surface-enhanced Raman spectroscopy. Nano Biomedicine and Engineering. 2017; 9: 49-56.
6. Zhi X, Lin L, Chen D. Surface enhanced Raman scattering (SERS): From fundamental mechanism to bio-analytics tools. Nano Biomedicine and Engineering. 2016; 8: 297-305.
7. Meng C†, Zhi X†, Li C, Li C, Chen Z, Qiu X, et al. Graphene oxides decorated with carnosine as an adjuvant to modulate innate immune and improve adaptive immunity in vivo. ACS Nano. 2016; 10: 2203-13.
8. Zhang J, Li C, Zhi X, Ramon G A, Liu Y, Zhang C, et al. Hairpin DNA-templated silver nanoclusters as novel beacons in strand displacement amplification for MicroRNA detection. Analytical Chemistry. 2016; 88: 1294-302.
9. Liu Y, Yang M, Zhang J, Zhi X, Li C, Zhang C, et al. Human induced pluripotent stem cells for tumor targeted delivery of gold nanorods and enhanced photothermal therapy. ACS Nano. 2016; 10: 2375-85.
10. Cui D, Ma L, Zhi X, Zhang C. Advance and prospects of nanotheranostic technology for gastric cancer. Nano Biomedicine and Engineering. 2016; 8: 219-39.
11. Zhang C, Zhou Z, Zhi X, Ma Y, Wang K, Wang Y, et al. Insights into the distinguishing stress-induced cytotoxicity of chiral gold nanoclusters and the relationship with GSTP1. Theranostics. 2015; 5: 134-49.
12. Lin S, Chen D, Xie Y, Zhi X, Wei Q, Pan F, et al. Single cell manipulation technology. Nano Biomedicine & Engineering. 2015; 7: 75-91.
13. Zhang J, Song Y, Zhang C, Zhi X, Fu H, Ma Y, et al. Circulating MiR-16-5p and MiR-19b-3p as two novel potential biomarkers to indicate progression of gastric cancer. Theranostics. 2015; 5: 733-45.
14. Xie Y†, Zhi X†, Su H, Wang K, Yan Z, He N, et al. A novel electrochemical microfluidic chip combined with multiple biomarkers for early diagnosis of gastric cancer. Nanoscale Research Letters. 2015; 10: 1-9.
15. Zhi X, Deng M, Yang H, Gao G, Wang K, Fu H, et al. A novel HBV genotypes detecting system combined with microfluidic chip, Loop-mediated isothermal amplification and GMR sensors. Biosensors & Bioelectronics. 2014, 54: 372-377.
16. Zhi X†, Fang HL†, Bao CC, Shen GX, Zhang J, Wang K, et al. The immunotoxicity of graphene oxides and the effect of PVP-coating. Biomaterials. 2013, 34(21): 5254-5261.
17. Zhi Xiao†, Liu QS†, Zhang X, Zhang Y, Feng J, Cui DX. Quick genotyping detection of HBV by giant magnetoresistive biochip combined with PCR and line probe assay. Lab on a Chip. 2012, 12(4): 741-745.
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