解丽娟 - 华侨大学 - 生物医学学院

个人简介

华侨大学医学院副研究员本科毕业于华东理工大学化学制药专业研究生（硕博）就读于大连理工大学精细化工国家重点实验室应用化学专业先后在香港中文大学和美国德州大学奥斯丁分校作访问学者主持课题 1. 抑制白血病细胞生长的萘酰亚胺类化合物的研究。泉州市科技计划项目，项目编号2019C033R 2. 氨萘非特增效、减毒新方法的研究。福建省科技厅社会发展重点项目，项目编号2013Y0066 3. 聚乙二醇修饰的氨萘非特作为抗肿瘤药物的研究。侨办课题，项目编号11J0277 4. 对神经细胞内钙离子和一氧化氮进行同步检测的荧光探针。大连理工大学精细化工国家重点实验室开放课题，项目编号KF0901 5. 含有1，8-萘酰亚胺单体的聚乙烯亚胺类非病毒基因载体的研究。华南肿瘤学国家重点实验室开放课题，2009.8-2011.7 6. 5-位芳香基团取代的萘酰亚胺类化合物的设计、合成及生物活性研究。项目编号09Y0142 此外参与两项国家自然基金课题研究专利解丽娟(共同专利发明人，第1位)“酰亚胺位或4-位取代的1，8-萘酰亚胺衍生物作为PARP抑制剂的用途”。CN201410072552.3 解丽娟(发明人，第1位)“一类萘酰亚胺双光子荧光染料、其制备方法和应用”。CN201511000130.6 作为共同专利发明人共获得授权专利十三项

研究领域

1. 抗肿瘤药物针对乳腺癌、白血病等恶性肿瘤的化合物的设计、合成及生物活性研究 2. 细胞器靶向荧光探针研究

近期论文

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1.1 Jinfeng Yu, Hui Bian, Huizi Man, Ning Li, Lijuan Xie,* , Yi Xiao,**Two–photon excitable red fluorophores for imaging living cells. Dyes and Pigments, 2018, 149,851–857 1.2 解丽娟*,陈卓.类呋喃香豆素的合成与DNA的结合及细胞毒性研究.光谱学与光谱分析,2014，34（11），3051-3055 .SCI收录 1.3 解丽娟*，李建民. 7-二乙胺基-3-(2’-吡啶)香豆素的新用途:溶酶体荧光探针.发光学报, 2013, 34(11), 1538-1543.EI收录 1.4 Yinghui Chen, Jianzhang Zhao, Lijuan Xie, Huimin Guo, Qiuting Li. Thienyl-substituted BODIPYs with strong visible light-absorption and long-lived triplet excited states as organic triplet sensitizers for triplet–triplet annihilation upconversion. RSC Adv., 2012, 2, 3942-3953. 1.5 Yinghui Chen, Jianzhang Zhao, Huimin Guo, Lijuan Xie. Geometry Relaxation-Induced Large Stokes Shift in Red-Emitting Borondipyrromethenes (BODIPY) and Applications in Fluorescent Thiol Probes. J. Org. Chem., 2012, 77 (5), 2192–2206. 1.6 Lijuan Xie*, Yinghui Chen, Wenting Wu, Huimin Guo, Jianzhang Zhao, Xuerong Yu. Fluorescent coumarin derivatives with large stokes shift, dual emission and solid state luminescent properties: An experimental and theoretical study. Dyes and Pigments, 2012, 92, 1361-1369. 1.7 Xu Ke; Liang Xin; Wang Fang; Xie Lijuan; Xu Yufang; Liu Jianwen; Qian Xuhong. Induction of G(2)/M phase arrest and apoptosis by potent antitumor APCA in human cervix carcinoma cells. ANTI-CANCER DRUGS., 2011, 22 (9), 875-885. 1.8 Lijuan Xie, Jingnan Cui, Xuhong Qian, Yufang Xu, Jianwen Liu, R.A.Xu. 5-Non-amino aromatic substituted naphthalimides as potential antitumor agents: Synthesis via Suzuki reaction, antiproliferative activity, and DNA-binding behavior. Bioorganic & Medicinal Chemistry, 2011; 19 (2), 961-967. 1.9 Li-juanXie*, 5-Butylamino-2-[2-(dimethylamino)-ethyl]-1H-benz[de] isoquinoline-1,3(2H) -dione. Acta Crystallographica Section E, 2010, E66, O1454-U1788 1.10 Lijuan Xie,Yi Xiao, Fang Wang, Jianwen Liu, Yufang Xu, Xuhong Qian, Jingnan Cui. Rong Zhang. Novel acenaphtho[1,2-b]pyrrole-carboxylic acid family: Synthesis, cytotoxicity, DNA-binding and cell cycle evaluation. Bioorganic & Medicinal Chemistry, 2009, 17, 7615–7621. 1.11 Kewei Wang, Jingnan Cui, Lijuan Xie, Xuhong Qian. Design, synthesis, and Evaluation of Unsymmetrical Difluoro-Boron Complexes with Imidazoline as Potential Fungicides. Heteroatom Chemistry, 2009, 20 (7), 418-424. 1.12 Lijuan Xie, Yufang Xu, Fang Wang, Jianwen Liu, Xuhong Qian, Jingnan Cui. Synthesis of new amonafide analogues via coupling reaction and their cytotoxic evaluation and DNA-binding studies. Bioorganic & Medicinal Chemistry, 2009, 16, 804-810. 1.13 Lijuan Xie, Xuhong Qian, Jingnan Cui, Yi Xiao, Kewei Wang, Peichun Wu, Liying Cong. Novel angular furoquinolinones bearing flexible chain as antitumor agent: Design, synthesis, cytotoxic evaluation, and DNA-binding studies. Bioorganic & Medicinal Chemistry, 2008, 16, 8713-8718.