李向敏 - 广东省微生物研究所 -

个人简介

主持项目（省部级以上）： 1. 国家自然科学青年基金项目，31700020，西藏新种白肉灵芝乙醇提取物抑制乳腺癌生长的化学成分及其作用机制，2018-01至2020-12，23万元，在研，主持 2.广东省自然科学基金项目，2017A030310088，西藏药用真菌白肉灵芝抗肿瘤物质基础与作用机制研究，2017-10至2019-9，10万元，已结题，主持 3. 广东省科技攻关项目，2010B080701108，食用菌风味休闲食品的研制及产业化技术研究，2011-01至2013-11，20万元，已结题，主持

研究领域

食药用菌活性成分抗肿瘤及肿瘤免疫调控机制研究

近期论文

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1. X. Li, M. Sdiri, J. Peng, Y. Xie, B. Yang, Identification and characterization of chemical components in the bioactive fractions of Cynomorium coccineum that possess anticancer activity, International Journal of Biological Sciences, 16 (2020) 61-73. 2. X. Li, Y. Xie, J. Peng, H. Hu, Q. Wu, B. Yang, Ganoderiol F purified from Ganoderma leucocontextum retards cell cycle progression by inhibiting CDK4/CDK6, Cell Cycle, 18 (2019) 1-14. 3. X. Li, Y. Xie, B. Yang, Characterizing novel anti-oncogenic triterpenoids from ganoderma, Cell cycle, 17 (2017). 4. X. Li, Q. Wu, M. Bu, L. Hu, W. Du, C. Jiao, H. Pan, M. Sdiri, N. Wu, Y. Xie, B. Yang, Ergosterol peroxide activates Foxo3-mediated cell death signaling by inhibiting AKT and c-Myc in human hepatocellular carcinoma cells, Oncotarget, 7 (2016). 5. X. Li, Q. Wu, Y. Xie, Y. Ding, W. Du, M. Sdiri, B. Yang, Ergosterol purified from medicinal mushroom Amauroderma rude inhibits cancer growth in vitro and in vivo by up-regulating multiple tumor suppressors, Oncotarget, 6 (2015). 1. W. Du, W. Yang, X. Li, L. Fang, N. Wu, F. Li, Y. Chen, Q. He, E. Liu, Z. Yang, F. Awan, M. Liu, B. Yang, The Circular RNA circSKA3 Binds Integrin β1 to Induce Invadopodium Formation Enhancing Breast Cancer Invasion, Molecular Therapy, 28 (2020). 2. W. Du, W. Yang, X. Li, F. Awan, Z. Yang, L. Fang, J. Lyu, F. Li, C. Peng, S. Krylov, Y. Xie, Y. Zhang, C. He, N. Wu, C. Zhang, M. Sdiri, J. Dong, J. Ma, C. Gao, B. Yang, A circular RNA circ-DNMT1 enhances breast cancer progression by activating autophagy, Oncogene, 37 (2018) 1. 3. S. Chen, X. Li, T. Yong, Z. Wang, J.-Y. Su, C. Jiao, Y. Xie, B. Yang, Cytotoxic lanostane-type triterpenoids from the fruiting bodies of Ganoderma lucidum and their structure-activity relationships, Oncotarget, 8 (2016). 1. M. Sdiri, X. Li, W. Du, S. El Bok, Y.-Z. Xie, M. Ben-Attia, B. Yang, Anticancer Activity of Cynomorium coccineum, Cancers, 10 (2018) 354. 2. T. Yong, S. Chen, Y. Xie, O. Shuai, X. Li, D. Chen, J.-Y. Su, C. Jiao, Y. Liang, Hypouricemic Effects of Extracts From Agrocybe aegerita on Hyperuricemia Mice and Virtual Prediction of Bioactives by Molecular Docking, Frontiers in Pharmacology, 9 (2018). 3. Y. Zeng, W. Du, Y. Wu, Z. Yang, F. Awan, X. Li, W. Yang, C. Zhang, Q. Yang, A. Yee, Y. Chen, F. Yang, H. Sun, R. Huang, R.-K. Li, Z. Wu, P. Backx, B. Yang, A Circular RNA Binds To and Activates AKT Phosphorylation and Nuclear Localization Reducing Apoptosis and Enhancing Cardiac Repair, Theranostics, 7 (2017) 3842-3855. 4. Q. Yang, W. Du, N. Wu, W. Yang, F. Awan, L. Fang, J. Ma, X. Li, Y. Zeng, Z. Yang, J. Dong, A. Khorshidi, B. Yang, A circular RNA promotes tumorigenesis by inducing c-myc nuclear translocation, Cell death and differentiation, 24 (2017). 5.Y. Ding, C. Xiao, Q. Wu, Y. Xie, X. Li, H. Hu, L. Li, The Mechanisms Underlying the Hypolipidaemic Effects of Grifola frondosa in the Liver of Rats, Frontiers in Microbiology, 7 (2016). 6. W. Du, W. Yang, Y. Chen, Z.-K. Wu, F. Foster, Z. Yang, X. Li, B. Yang, Foxo3 circular RNA promotes cardiac senescence by modulating multiple factors associated with stress and senescence responses, European Heart Journal, 38 (2016) ehw001.