个人简介
主持项目（省部级以上）：
1. 国家自然科学基金青年基金，基于协同进化原则的蛋白质结构域重组策略及其在构建超嗜热脂肪酶中的应用（项目编号：31400681）
2. 吉林省自然科学基金，肝癌细胞丙酮酸激酶双重调节糖代谢机制及靶向药物的筛选（项目编号：20180101307JC）
3. 吉林省科技厅青年科研基金，蛋白质结构域重组构建新型热稳定丝氨酸蛋白酶抑制剂 （项目编号： 20160520142JH）
4. 吉林省卫生计生青年科研课题，嗜热丝氨酸蛋白酶抑制剂Pnserpin 的结构功能及抗炎活性研究（项目编号： 2015Q016）
5. 吉林省择优资助博士后科研项目，以丙酮酸脱氢酶激酶为靶点的药物筛选及抗肿瘤作用研究
6. 广东省科学院引进全职博士学位人才资助专项项目，天然产物生物合成中稀有糖基转移酶Gra-ORF14 的催化活性研究（2018GDASCX-0908），2018.1-2019.12
近期论文
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1. Zhou X, Xu Z, He J, Li Y, Pan C, Wang C, Deng M, Zhu H*. A myxobacterial LPMO10 has oxidizing cellulose activity for promoting biomass enzymatic saccharigication of agricultural crop straws. Bioresour. Technol. 2020, 318:124217.
2. Zhou X, Zhu H*. Current understanding of substrate specificity and regioselectivity of LPMOs, Bioresour. Bioprocess. 2020, 7(1): 11.
3. Zhou X, Qi X, Huang H, Zhu H*. Sequence and structural analysis of AA9 and AA10 LPMOs: an insight into the basis of substrate specificity and regioselectivity, Int. J. Mol. Sci. 2019, 20(18): 4594-4608.
4. Zhang H, Fei R, Xue B, Yu S, Zhang Z, Zhong S, Gao Y, Zhou X*. Pnserpin:a novel serine protease inhibitor from extremophile pyrobaculum neutrophilum, Int. J. Mol. Sci. 2017, 18(1): 113-126.
5. Zhou X, Yu S, Su J, Sun L *. Computational study on new natural compound inhibitors of pyruvate dehydrogenase kinases. Int. J. Mol. Sci. 2016, 17(3):340-352.
6. Zhang W, Su J, Xu H, Yu S, Liu Y, Zhang Y, Sun L, Yue Y*, Zhou X*. Dicumarol inhibits PDK1 and targets multiple malignant behaviors of ovarian cancer cells, Plos One, 2017, 12(6): e0179672.
7. Zhou X, Gao L, Yang G, Liu D, Bai A, Li B, Deng Z, Feng Y*. Design of hyperthermophilic lipase chimeras by key motif-directed recombination, Chembiochem, 2015, 16(3): 455-462.
8. Yu S, Zhou X, Li F, Xu C, Zheng F, Li J, Zhao H, Dai Y, Liu S, Feng Y*. Microbial transformation of ginsenoside Rb1, Re and Rg1 and its contribution to the improved anti-inflammatory activity of ginseng. Sci. Rep. 2017.7(1):138-147.
9. Fei R, Zhang H, Zhong S, Xue B, Gao Y, Zhou X*. Anti-inflammatory activity of a thermophilic serine protease inhibitor from extremophile Pyrobaculum neutrophilum. Eur. J. Inflamm. 2017,15(3):143-151.
10. Zhou X, Han W, Zheng B, Feng Y*. Insight into substrate preference of two chimeric esterases by combining experiment and molecular simulation. Chem. Res. Chin. Univ. 2013, 29(3): 533-537.
11. Zhou X, Wang H, Zhang Y, Gao L, Feng Y*. Alteration of substrate specificities of thermophilic alpha/beta hydrolases through domain swapping and domain interface optimization. Acta. Biochim. Biophys. Sin. 2012, 44(12): 965-973.
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