个人简介
近年来，以模式生物酿酒酵母为研究对象，将微流控高通量筛选平台成功应用于高淀粉酶分泌酵母菌株的分选，并对酿酒酵母内部营养代谢调控机理及蛋白分泌途径进行解析阐述，实现重组淀粉酶高分泌酵母菌株的理性设计构建，推进了微流控、系统与合成生物学等前沿技术的融合应用。在PNAS、 Nature Communications、 Cell、Lab Chip、AEM、Curr. Opin. Biotech等国际著名期刊发表多篇论文，受邀担任Metab. Eng.、ACS Synth. Bio.、Biotech. and Bioeng.、Biotech. Biofuel.等专业期刊审稿人。
1. 教育背景
2002-2006，中山大学，生物技术，学士
2006-2011，中山大学，微生物学，博士(硕博连读)
2. 工作经历
2012-2017，瑞典查尔莫斯理工大学，博士后
2017-2019，广州汉腾生物科技有限公司，研发总监
2019至今，华南理工大学食品科学与工程学院，教授
近期论文
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1. Guokun Wang, Sara M Björk, Mingtao Huang, Quanli Liu, Kate Campbell, Jens Nielsen, Håkan N Jönsson* and Dina Petranovic* (2019). RNAi expression tuning, microfluidic screening, and genome recombineering for improved protein production in Saccharomyces cerevisiae. PNAS. 116(19):9324-9332.
2. Mingtao Huang, Guokun Wang, Jiufu Qin, Dina Petranovic and Jens Nielsen* (2018). Engineering the protein secretory pathway of Saccharomyces cerevisiae enables improved protein production. PNAS. 115(47):E11025-E11032.
3. Zongjie Dai, Mingtao Huang, Yun Chen, Verena Siewers and Jens Nielsen* (2018). Global rewiring of cellular metabolism renders Saccharomyces cerevisiae Crabtree negative. Nature Commun. 9:3059.
4. Tao Yu#, Yongjin J. Zhou#, Mingtao Huang, Quanli Liu, Rui Pereira, Florian David and Jens Nielsen* (2018). Reprogramming Saccharomyces cerevisiae metabolism from alcoholic fermentation to lipogenesis. Cell. 174(6):1549-1558.
5. Mingtao Huang,Haakan N. Joensson and Jens Nielsen*(2018).High-throughput microfluidics for the screening of yeast libraries. Methods Mol. Biol. 1671:307-317.
6. Mingtao Huang, Jichen Bao, Björn M. Hallström, Dina Petranovic and Jens Nielsen*(2017). Efficient protein production by yeast requires global tuning of metabolism. Nature Commun. 8:1131.
7. Jichen Bao#,Mingtao Huang#, Dina Petranovic and Jens Nielsen*(2017). Moderate expression of SEC16 increases protein secretion by Saccharomyces cerevisiae. Appl. Environ. Microbiol.83(14): e03400-16.
8. Guokun Wang#, Mingtao Huang# and Jens Nielsen* (2017). Exploring the potential of Saccharomyces cerevisiae for biopharmaceutical protein production. Curr. Opin. Biotechnol. 48:77-84.
9. Mingtao Huang#, Yunpeng Bai#, Staffan L. Sjostrom, Björn M. Hallström, Zihe Liu, Dina Petranovic, Mathias Uhlén,Haakan N. Joensson, Helene Andersson Svahn and Jens Nielsen* (2015). Microfluidic screening and whole-genome sequencing identifies mutations associated with improved protein secretion by yeast. PNAS. 112(34):E4689–E4696.
10. Jiufu Qin, Yongjin J. Zhou, Anastasia Krivoruchko, Mingtao Huang, Lifang Liu, Sakda Khoomrung, Verena Siewers, Bo Jiang* and Jens Nielsen* (2015). Modular pathway rewiring of Saccharomyces cerevisiae enables high-level production of L-ornithine. Nature Commun. 6:8224.
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