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招生专业 090801-水产养殖 招生方向 鱼类分子遗传育种,鱼类生殖发育调控 教育背景 1997-09--中国科学院水生生物研究所 博士 1991-09--中国科学院水生生物研究所 硕士 1987-09--南开大学生物系 学士 工作简历 2011-08~2012-03,University of Ottawa, 访问学者 2010-06~2010-08,香港中文大学, 访问学者 2007-07~现在, 中国科学院水生生物研究所, 研究员 2002-01~现在, 中国科学院水生生物研究所, 副研究员 1997-09~现在, 中国科学院水生生物研究所, 博士 1996-07~现在, 中国科学院水生生物研究所, 助理研究员 1994-07~现在, 中国科学院水生生物研究所, 研究实习员 1991-09~现在, 中国科学院水生生物研究所, 硕士 1987-09~现在, 南开大学生物系, 学士 教授课程 水产生物杂交育种、基因工程与基因编辑定向育种 转基因鱼育种及其生物安全研究 专利成果 ( 1 ) 一种壳聚糖甲基睾酮缓释药条的制备方法, 2007, 第 1 作者, 专利号: ZL200510018148.9 ( 2 ) A recombinant gene which enhances the ability of fish to tolerate low dissolved oxygen stress and the use thereof, 2013, 第 1 作者, 专利号: US12/879931 ( 3 ) 不育转基因鱼的制备方法, 2007, 第 1 作者, 专利号: ZL031254551 ( 4 ) Controllable on-off method for fish reproduction, 2015, 第 1 作者, 专利号: US 9,187,764 B2 ( 5 ) Method for preparing a sterile transgenic carp, 2007, 第 1 作者, 专利号: US7,230,156B2 ( 6 ) 一种超雄鲤鱼和遗传雄性而生理雌性鲤鱼的制备方法, 2018, 第 1 作者, 专利号: ZL201710315756.9 ( 7 ) 一种控制鱼类生殖的方法, 2014, 第 1 作者, 专利号: ZL201310049161.5 ( 8 ) 一种雌性鲤鱼性逆转为雄性鲤鱼的培育方法, 2012, 第 1 作者, 专利号: ZL201110186519.X ( 9 ) Method for production YY super-male and XY physiological female common carps, 2020, 第 1 作者, 专利号: US15870334 ( 10 ) 一种黄鳝基因编辑的方法, 2019, 第 1 作者, 专利号: CN201610651812.1 ( 11 ) 一种控制黄鳝受精卵第一次卵裂的方法及其应用, 2017, 第 1 作者, 专利号: 201711265194.8 科研项目 ( 1 ) 鱼类生殖发育调控的模型研究, 主持, 国家级, 2010-01--2014-12 ( 2 ) 功能基因育种潜力的验证与新育种技术研究, 主持, 国家级, 2011-01--2015-12 ( 3 ) 鱼类生殖和抗病抗逆的基础研究, 主持, 部委级, 2011-01--2014-12 ( 4 ) 鱼类基因工程育种, 主持, 国家级, 2014-01--2017-12 ( 5 ) 鱼类雌雄同体两性性腺分化发育的机制研究, 主持, 国家级, 2015-01--2017-12 ( 6 ) 鲤性别控制的分子模块解析, 主持, 部委级, 2013-08--2018-07 ( 7 ) 鱼类分子遗传育种, 主持, 国家级, 2018-01--2023-12 ( 8 ) 新因子fam60a在斑马鱼PGCs形成中的功能及其育种探索, 主持, 国家级, 2018-01--2021-12 ( 9 ) 重要养殖鱼类优良种质创制与生殖操作技术研究, 主持, 国家级, 2018-12--2022-12 参与会议 (1)鱼类生殖的遗传网络调控机理及生殖操作育种 国家自然科学基金委员会第190期“动物优良种质创制的关键理论和技术”双清论坛 2017-10-18 (2)Regulatory mechanisms of reproduction and reproductive manipulation breeding in fish 2017-10-10 (3)鱼类基因工程育种--以冠鲤为例 第十次全国动物生物技术学术研讨会 2017-08-08 (4)sgIIb基因在斑马鱼胚胎后脑血管发育中的功能研究 中国水产学会生物技术研究与应用学术研讨会 2017-03-11 (5)鱼类生殖发育调控研究 中国水产学会淡水养殖分会年会 2016-11-10 (6)Regulatory mechanisms of growth and reproduction in growth hormone-transgenic common carp Hu Wei 2016-06-28 (7)Transgenic fish and its Reproductive Containment Strategies Hu Wei 2014-03-19 (8)GROWTH HORMONE TRANSGENESIS AFFECTS NEUROENDOCRINE REGULATION AND REPRODUCTION IN THE COMMON CARP CYPRINUS CARPIO L. Hu Wei 2013-05-22 (9)GH transgene effects on growth performance are inconsistent among transgenic offspring Hu Wei 2012-12-01 (10)MOLECULAR CLONING, PROMOTER ACTIVITY ANALYSIS AND DISCOVERY OF A NOVEL GONAODOTROPIN-RELEASING HOMONRE TRANSCRIPT IN THE ORANGE-SPOTTED GROUPER (EPINEPHELUS COIOIDES) Yu-Shan Luo, Xiao-Chun Liu, Yue-Qing Yang, Hao-Ran Lin, Zuo-Yan Zhu, Wei Hu 2011-05-10 (11)Molecular cloning and mRNA expression pattern of Sox9 during sex reversal in orange-spotted grouper (Epinephelus coioides) Luo Y, Hu W and ZHu Z 2010-01-19 (12)CONSTRUCTION AND ANALYSIS OF THE SUBTRACTIVE Xu J, Hu W, Zhu Z 2009-06-20

近期论文

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(1) Targeted mutation of secretogranin-2 disrupts sexual behavior and reproduction in zebrafish, Proc. Natl. Acad. Sci. USA, 2020, 通讯作者 (2) Gnrh3 regulates PGC proliferation and sex differentiation in developing zebrafish, Endocrinology, 2020, 通讯作者 (3) Kisspeptin2 Regulates Hormone Expression in Female Zebrafish (Danio rerio) Pituitary, Molecular and Cellular Endocrinology, 2020, 通讯作者 (4) Timing of gonadal development and dimorphic expression of sex-related genes in gonads during early sex differentiation in the Yellow River carp, Aquaculture, 2020, 通讯作者 (5) Telophase of the first cleavage is the key stage for optimally inducing mitotic gynogenesis in rice field eel (Monopterus albus), Aquaculture, 2020, 通讯作者 (6) Mettl3 mutation disrupts gamete maturation and reduces fertility in zebrafish, Genetics, 2018, 通讯作者 (7) Fam60al as a novel factor involved in reprogramming of somatic cell nuclear transfer in zebrafish (Danio rerio), International Journal of Biological Sciences, 2018, 通讯作者 (8) Production of YY super-male and XY physiological female common carp for potential eradication of this invasive species, Journal of the World Aquaculture Society, 2018, 通讯作者 (9) Growth hormone overexpression disrupts reproductive status through actions on leptin, Frontiers in Endocrinology, 2018, 通讯作者 (10) Efficient gene transfer and gene editing in sterlet (Acipenser ruthenus), Frontiers in Genetics, 2018, 通讯作者 (11) Secretogranin-II plays a critical role in zebrafish neurovascular modeling, Journal of Molecular Cell Biology, 2018, 通讯作者 (12) Alternative splicing of GnRH2 and GnRH2-associated peptide plays an important role in gonadal differentiation of the rice field eel, Monopterus albus, General and Comparative Endocrinology, 2018, 通讯作者 (13) High efficient gene targeting in rice field eel Monopterus albus by transcription activator-like effector nucleases, Science Bulletin, 2017, 通讯作者 (14) GABAergic Neurons and Their Modulatory Effects on GnRH3 in Zebrafish, Endocrinology, 2017, 通讯作者 (15) Disruption of dmc1 Produces Abnormal Sperm in Medaka (Oryzias latipes), Scientific Reports, 2016, 通讯作者 (16) GnIH plays a negative role in regulating GtH expression in the common carp, Cyprinus carpio L, General and Comparative Endocrinology, 2016, 通讯作者 (17) The basal function of teleost prolactin as a key regulator on ion uptake identified with zebrafish knockout models, Scientific Reports, 2016, 通讯作者 (18) A controllable on-off strategy for the reproductive containment of fish, Scientific reports, 2015, 通讯作者 (19) The distribution of Kiss1- and Kiss2-positive neurones and their connections with GnRH3 neurones in the zebrafish brain, Journal of Neuroendocrinology, 2015, 通讯作者 (20) Effects of growth hormone over-expression on reproduction in the common carp Cyprinus carpio L. , General and Comparative Endocrinology, 2014, 通讯作者 (21) Targeted gene disruption in zebrafish reveals noncanonical functions of Lh signaling in reproduction, Molecular Endocrinology, 2014, 通讯作者 (22) Critical Developmental Stages For The Efficiency Of Somatic Cell Nuclear Transfer In Zebrafish, International Journal of Biological Sciences, 2011, 通讯作者 (23) Defining Global Gene Expression Changes of the Hypothalamic-Pituitary-Gonadal Axis in Female sGnRH-Antisense Transgenic Common Carp (Cyprinus carpio), PLoS One, 2011, 通讯作者 (24) Vitreoscilla Hemoglobin (VHb) Overexpression Increases Hypoxia Tolerance in Zebrafish (Danio rerio), Marine Biotechnology, 2011, 通讯作者 (25) Production, characterization, and applications of mouse monoclonal antibodies against gonadotropin, somatolactin, and prolactin from common carp (Cyprinus carpio), General and Comparative Endocrinology, 2010, 通讯作者 (26) Non-Homologous End Joining Plays a Key Role in Transgene Concatemer Formation in Transgenic Zebrafish Embryos, International Journal of Biological Sciences, 2010, 通讯作者 (27) Developmental expression of steroidogenic factor-1, cyp19a1a and cyp19a1b from common carp (Cyprinus carpio), General and Comparative Endocrinology, 2010, 通讯作者 (28) Identification of Differentially Expressed Genes Between Cloned and Zygote-Developing Zebrafish (Danio rerio) Embryos at the Dome Stage Using Suppression Subtractive Hybridization, Biology of Reproduction , 2009, 通讯作者 (29) Antisense for gonadotropin-releasing hormone reduces gonadotropin synthesis and gonadal development in transgenic common carp (Cyprinus carpio), Aquaculture, 2007, 第 1 作者

学术兼职

2019-11-01-今,国家水产原种和良种审定委员会, 委员 2018-05-04-今,Comparative Biochemistry and Physiology A Molecular and Integrative Physiology、Comparative Biochemistry and Physiology B Biochemistry and Molecular Biology、Comparative Biochemistry and Physiology C Toxicology and Pharmacology和Comparative Biochemistry and Physiology D Genomics and Proteomics期刊的编委, 2016-11-01-今,中国水产学会淡水养殖分会, 副主任委员 2013-09-01-今,中国动物学会比较内分泌学会, 理事 2013-04-01-今,第四届国家农业转基因生物安全委员会, 委员 2011-09-01-今,遗传, 编委 2009-11-01-今,农业生物技术学报, 编委 2007-09-01-今,中国水产学会水产生物技术专业委员会, 委员

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