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个人简介

工作经历 2022.01-至今 研究员 哈尔滨工业大学生命科学与技术学院 2017.04-2021.12 副教授(准聘) 哈尔滨工业大学生命学院 2012.12-2015.12 博士后 美国纽约西奈山医学院 2012.09-2017.03 副教授 哈尔滨医科大学生物信息科学与技术学院 教育经历 2008/9 - 2011/6 生物物理学 哈尔滨医科大学 博士 2004/9 - 2006/7 计算机科学与技术 哈尔滨工业大学 硕士 2000/9 - 2004/7 软件工程 哈尔滨工业大学 本科

研究领域

自2005年起长期从事复杂疾病相关生物分子标志物的生物信息学和系统生物学的研究。2012年12月至2015年12月在美国纽约西奈山医学院生物信息学研究中心,从事计算生物学和基因组学的研究工作,在生物分子网络分析、癌症相关分子标志物挖掘、高通量测序组学数据分析等方面都积累了丰富的研究经验,相关成果发表在《Molecular Cell》、《Briefings in Bioinformatics》、《Cancer Research》、《Cell stem Cell》等杂志上。回国后加入哈工大生命学院,现在的主要研究方向是肠道微生物与疾病的关联研究,主要基于宏基因组数据来进行CRISPR相关的研究工作和微生物群落间的动态相互作用等研究工作

近期论文

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Zhou F#*, Yu X#, Gan R#, Ren K, Chen C, Ren C, Cui M, Liu Y, Gao Y, Wang S, Yin M, Huang T, Huang Z*, Zhang F.an *. CRISPRimmunity: an interactive web server for CRISPR-associated Important Molecular events and Modulators Used in geNome edIting Tool identifYing. Nucleic Acids Res. 2023 Jul 5;51(W1):W93-W107. (IF: 14.9) Zhou F, Yang H, Si Y, Gan R, Yu L, Chen C, Ren C, Wu J, Zhang F. PhageTailFinder: A tool for phage tail module detection and annotation. Front Genet. 2023 Jan 23;14:947466. (IF: 3.7) Gan R, Zhou F, Si Y, Yang H, Chen C, Ren C, Wu J, Zhang F*. DBSCAN-SWA: An Integrated Tool for Rapid Prophage Detection and Annotation. Front Genet. 2022 Apr (IF: 3.7) Zhou, F.(#), Gan, R.(#), Zhang, F.(#), Ren, C., Jia, Y., Yu, L. and Huang, Z*. (2021) PHISDetector: A Tool to Detect Diverse in silico Phage-host Interaction Signals for Virome Studies. Genomics, Proteomics & Bioinformatics (2022, co-first author IF: 7.691) Fan Zhang, Zhiwei Huang*. Mechanistic Insights into the Versatile Class II CRISPR Toolbox. Trends in Biochemical Sciences. (IF: 13.807, invited review 2021) Shengli Ma(#)*, Fan Zhang(#), Fengxia Zhou(#), Hui Li(#), Wenyu Ge, Rui Gan, Huan Nie, Biao Li, Yindong Wang, Meng Wu, Duo Li, Dongmei Wang, Zheng Wang, Yuhong You & Zhiwei Huang* Metagenomic analysis reveals oropharyngeal microbiota alterations in patients with COVID-19. Sig Transduct Target Ther 6, 191 (2021). https://doi.org/10.1038/s41392-021-00614-3 (IF: 18.187 co-first author) Ren, X.#,Wen, W.#, Fan, X.#, Hou, W.#, Su, B.#, Cai, P.#, Li, J.#, Liu, Y.#, Tang, F. #, Zhang, F. #, Yang, Y.#, He, J. #, Ma, W. #, He, J. #, Wang, P. #, Cao, Q., Chen, F., Chen, Y., Cheng, X., Deng, G., Deng, X., Ding, W., Feng, Y., Gan, R., Guo, C., Guo, W., He, S., Jiang, C., Liang, J., Li, Y.-m., Lin, J., Ling, Y., Liu, H., Liu, J., Liu, N., Liu, S.-Q., Luo, M., Ma, Q., Song, Q., Sun, W., Wang, G., Wang, F., Wang, Y., Wen, X., Wu, Q., Xu, G., Xie, X., Xiong, X., Xing, X., Xu, H., Yin, C., Yu, D., Yu, K., Yuan, J., Zhang, B., Zhang, P., Zhang, T., Zhao, J., Zhao, P., Zhou, J., Zhou, W., Zhong, S., Zhong, X., Zhang, S., Zhu, L., Zhu, P., Zou, B., Zou, J., Zuo, Z., Bai, F., Huang, X., Zhou, P., Jiang, Q.*, Huang, Z. *, Bei, J.-X. *, Wei, L. *, Bian, X.-W. *, Liu, X. *, Cheng, T. *, Li, X. *, Zhao, P. *, Wang, F.-S. *, Wang, H. *, Su, B. *, Zhang, Z. *,Qu, K. *, Wang, X. *, Chen, J. *, Jin, R. *, Zhang, Z. *, COVID-19 immune features revealed by a large-scale single cell transcriptome atlas, Cell (2021), doi: https://doi.org/10.1016/j.cell.2021.01.053.(co-first author,IF: 41.582) Fan Zhang(#), Rui Gan(#), Ziqi Zhen(#), Xiaoli Hu(#), Xiang Li, Fengxia Zhou, Ying Liu, Chuangeng Chen, Shuangyu Xie, Bailing Zhang, Xiaoke Wu & Zhiwei Huang*. Adaptive immune responses to SARS-CoV-2 infection in severe versus mild individuals. Sig Transduct Target Ther 5, 156 (2020). https://doi.org/10.1038/s41392-020-00263-y (IF: 18.187 cover story) Zhang, R.(#), F. Zhang(#), Z. Sun(#), P. Liu, X. Zhang, Y. Ye, B. Cai, M. J. Walsh, X. Ren, X. Hao, W. Zhang* and J. Yu* (2019). "LINE-1 Retrotransposition Promotes the Development and Progression of Lung Squamous Cell Carcinoma by Disrupting the Tumor Suppressor Gene FGGY." Cancer Research: canres.0076.2019. (co-first author, IF:12.701) Dong, L.#, Guan, X.#, Li, N.#, Zhang, F., Zhu, Y., Ren, K., Yu, L., Zhou, F., Han, Z., Gao, N. Huang, Z*. (2019) An anti-CRISPR protein disables type V Cas12a by acetylation. Nature Structural & Molecular Biology. (IF:15.369) Zhang, F.(#), Zhao, S.(#), Ren, C.(#), Zhu, Y., Zhou, H., Lai, Y., Zhou, F., Jia, Y., Zheng, K. and Huang, Z*. (2018) CRISPRminer is a knowledge base for exploring CRISPR-Cas systems in microbe and phage interactions. Commun Biol, 1, 180. (IF:6.268) Fan Zhang*, Chunyan Ren, Kwun Kit Lau, Zihan Zheng, Geming Lu, Zhengzi Yi, Yongzhong Zhao, Fei Su, Shaojun Zhang, Bin Zhang, Eric A. Sobie, Weijia Zhang*, Martin J. Walsh*, A network medicine approach to build a comprehensive atlas for the prognosis of human cancer, BRIEFINGS IN BIOINFORMATICS, 2016.11, 17(6): 1044~1059 (IF:11.622) Ka Lung Cheung(#), Fan Zhang(#), Anbalagan Jaganathan(#), Rajal Sharma, Qiang Zhang, Tsuyoshi Konuma, Tong Shen, June-Yong Lee, Chih-Hung Chen, Geming Liu, Weijia Zhang, Dan R. Littman, Martin J. Walsh, Huabao Xiong, & Ming-Ming Zhou* Distinct Roles of Brd2 and Brd4 in Potentiating the Transcriptional Program for Th17 Cell Differentiation, MOLECULAR CELL, 2017.3.16, 65(6): 1068~+ (co-first author IF:17.970) Zhu, Y., Zhang, F. & Huang, Z*. Structural insights into the inactivation of CRISPR-Cas systems by diverse anti-CRISPR proteins. BMC Biol 16, 32, doi:10.1186/s12915-018-0504-9 (2018). Aguilo, Francesca(*); Zhang, Fan; et.al, Coordination of m(6)A mRNA Methylation and Gene Transcription by ZFP217 Regulates Pluripotency and Reprogramming, CELL STEM CELL, 2015.12.3, 17(6): 689~704 (IF:24.633) Guo, Haiyang(#); Ahmed, Musaddeque(#); Zhang, Fan et.al, Modulation of long noncoding RNAs by risk SNPs underlying genetic predispositions to prostate cancer, NATURE GENETICS, 2016.10, 48(10): 1142~1150 (IF:38.330) Rengasamy, Madhumitha; Zhang, Fan et.al, The PRMT5/WDR77 complex regulates alternative splicing through ZNF326 in breast cancer, NUCLEIC ACIDS RESEARCH, 2017.8.21, 45(19): 11106~11120 (IF:16.971) Di Cecilia, Serena; Zhang, Fan et.al, RBM5-AS1 Is Critical for Self-Renewal of Colon Cancer Stem-like Cells., Cancer Res, 2016.10.1, 76(19): 5615~5627 (IF:12.701) Zhang, Fan(#) et. al Allele-Specific Behavior of Molecular Networks: Understanding Small-Molecule Drug Response in Yeast, PLos One, 2013.1.4, 8(1) (IF:3.24) Wu, Chao(#); Zhang, Fan(#) et.al Composite functional module inference: detecting cooperation between transcriptional regulation and protein interaction by mantel test, BMC Systems Biology, 2010.6.10, 4:1~11 Haines, Jeffery D.(#); Vidaurre, Oscar G.(#); Zhang, Fan(#); et.al, Multiple sclerosis patient-derived CSF induces transcriptional changes in proliferating oligodendrocyte progenitors, MULTIPLE SCLEROSIS JOURNAL, 2015.11, 21(13): 1655~1669 (co-first author, IF:6.312) Chen DiJun(#); Zhang Fan(#) et.al , A web-based platform for rice microarray annotation and data analysis, Science China Life Sciences, 2010.12, 53(12): 1467~1473 (co-first author, IF:6.038) Zhang, Fan(#); et.al, The enhancer landscape involves a core noncoding RNA protein interaction network for C-MYC expression, AACR Special Conference on Noncoding RNAs and Cancer - Mechanisms to Medicines, Boston, MA, 2015.12.4-2015.12.7 (会议论文) Zhang, Fan(#); et.al, A heuristic approach for target SNP mining based on genome-wide IBD profile, 3rd International Conference on Natural Computation (ICNC 2007), Haikou, PEOPLES R CHINA, 2007.8.24-2007.8.27 (会议论文) Liu, Jia; Magri, Laura; Zhang, Fan et.al, Chromatin Landscape Defined by Repressive Histone Methylation during Oligodendrocyte Differentiation, JOURNAL OF NEUROSCIENCE, 2015.1.7, 35(1): 352~365 (IF:6.167) Moyon, Sarah; Huynh, Jimmy L.; Dutta, Dipankar; Zhang, Fan et.al, Functional Characterization of DNA Methylation in the Oligodendrocyte Lineage, CELL REPORTS, 2016.4.26, 15(4): 748~760 (IF:9.423) Li, Chunquan; Li, Xia; Miao, Yingbo; Wang, Qianghu; Jiang, Wei; Xu, Chun; Li, Jing; Han, Junwei; Zhang, Fan et.al, SubpathwayMiner: a software package for flexible identification of pathways, Nucleic Acids Research, 2009.10, 37(19) (IF:10.162) Sancho, Ana; Li, SiDe; Paul, Thankam; Zhang, Fan et.al, CHD6 regulates the topological arrangement of the CFTR locus, HUMAN MOLECULAR GENETICS, 2015.5.15, 24(10): 2724~2732 (IF:6.150) Shaojun Zhang(#); Fang Wang(#); Hongzhi Wang; Fan Zhang; Bin Xu; Xia Li(*); Yadong Wang(*), Genome-wide identification of allele-specific effects on gene expression for single and multiple individuals, Gene, 2014.1.1, 533(1): 366~373 (IF:2.415) Han, Junwei; Liu, Siyao; Sun, Zeguo; Zhang, Yunpeng; Zhang, Fan et.al, LncRNAs2Pathways: Identifying the pathways influenced by a set of lncRNAs of interest based on a global network propagation method, SCIENTIFIC REPORTS, 2017.4.20, 7 (IF:4.259) Liu, Wei; Li, Chunquan; Xu, Yanjun; Yang, Haixiu; Yao, Qianlan; Han, Junwei; Shang, Desi; Zhang, Chunlong; Su, Fei; Li, Xiaoxi; Xiao, Yun; Zhang, Fan; Dai, Meng; Li, Xia, Topologically inferring risk-active pathways toward precise cancer classification by directed random walk, Bioinformatics, 2013.9.1, 29(17): 2169~2177 (IF:7.307) Li, Jiang; Gong, Binsheng; Chen, Xi; Liu, Tao; Wu, Chao; Zhang, Fan; Li, Chunquan; Li, Xiang; Rao, Shaoqi(*); Li, Xia, DOSim: An R package for similarity between diseases based on Disease Ontology, BMC Bioinformatics, 2011.6.29, 12 (IF:2.448) Cheung, Kalung(#); Lu, Geming(#); Sharma, Rajal; Vincek, Adam; Zhang, Ruihua; Plotnikov, Alexander N.; Zhang, Fan; et.al, BET N-terminal bromodomain inhibition selectively blocks Th17 cell differentiation and ameliorates colitis in mice, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2017.3.14, 114(11): 2952~2957 (IF:11.205) Aguilo, Francesca(#); Li, SiDe(#); Balasubramaniyan, Natarajan(#); Sancho, Ana; Benko, Sabina; Zhang, Fan; et.al, Deposition of 5-Methylcytosine on Enhancer RNAs Enables the Coactivator Function of PGC-1 alpha, CELL REPORTS, 2016.1.26, 14(3): 479~492 (IF: 8.282 ) Vidaurre, Oscar G.; Haines, Jeffery D.; Sand, Ilana Katz; Adula, Kadidia P.; Huynh, Jimmy L.; McGraw, Corey A.; Zhang, Fan et.al, Cerebrospinal fluid ceramides from patients with multiple sclerosis impair neuronal bioenergetics, BRAIN, 2014.8, 137: 2271~2286 (IF:13.501) Sun, Jie(#); Gao, Bo(#); Zhou, Meng(#)(*); Wang, Zhen-zhen; Zhang, Fan; Deng, Jia-en; Li, Xia, Comparative genomic analysis reveals evolutionary characteristics and patterns of microRNA clusters in vertebrates, Gene, 2013.1.10, 512(2): 383~391 Zhang, Shaojun; Xu, Liangde; Wang, Fang; Wang, Hongzhi; Gong, Binsheng; Zhang, Fan; Li, Xia(*); Wang, Yadong, Genetic control of primary microRNA insight into cis- and trans-regulatory variations by RNA-seq, Gene, 2013.4.1, 517(2): 224~229 Kuo, P-Y; Leshchenko, V. V.; Fazzari, M. J.; Perumal, D.; Gellen, T.; He, T.; Iqbal, J.; Baumgartner-Wennerholm, S.; Nygren, L.; Zhang, F.; et.al, High-resolution chromatin immunoprecipitation (ChIP) sequencing reveals novel binding targets and prognostic role for SOX11 in mantle cell lymphoma, ONCOGENE, 2015.3.5, 34(10): 1231~1240 (IF:7.519) Sullivan, Josefa M.; Badimon, Ana; Schaefer, Uwe; Ayata, Pinar; Gray, James; Chung, Chun-wa; von Schimmelmann, Melanie; Zhang, Fan; et.al, Autism-like syndrome is induced by pharmacological suppression of BET proteins in young mice, JOURNAL OF EXPERIMENTAL MEDICINE, 2015.10.19, 212(11): 1771~1781 (IF:14.307) Zhang RuiJie; Li Xia; Jiang YongShuai; Liu GuiYou; Li ChuanXing; Zhang Fan; et.al, Novel strategies to mine alcoholism-related haplotypes and genes by combining existing knowledge framework, Science China Life Sciences, 2009.2, 52(2): 163~172 Mathur, Deepali; Riffo-Campos, Angela L.; Castillo, Josefa; Haines, Jeffery D.; Vidaurre, Oscar G.; Zhang, Fan; et.al, Bioenergetic Failure in Rat Oligodendrocyte Progenitor Cells Treated with Cerebrospinal Fluid Derived from Multiple Sclerosis Patients, FRONTIERS IN CELLULAR NEUROSCIENCE, 2017.7.18, 11

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