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个人简介

2000-2004年:西南师范大学理学学士 2004-2009年:山东大学生化与分子生物学博士 2009-2016年:哈尔滨工业大学生命科学与技术学院讲师 2017-至 今:哈尔滨工业大学生命科学与技术学院副教授

研究领域

表观遗传学 主要研究组蛋白去甲基化酶在胚胎发育和肿瘤发育过程中的作用机制

近期论文

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Shuang Cui , Qiong Wu*, Ming Liu, Mu Su, ShiYou Liu, Lan Shao, Xiao Han and Hongjuan He*. EphA2 super-enhancer promotes tumor progression by recruiting FOSL2 and TCF7L2 to activate the target gene EphA2.Cell Death and Disease . 2021 Mar 12;12(3):264. Li H*, He H*, Wang Z, Cai J, Sun B, Wu Q, Zhang Y, Zhou G, Yang L: Rice protein suppresses ROS generation and stimulates antioxidant gene expression via Nrf2 activation in adult rats. Gene 2016, 585(2):256-264. Guo J, He H, Liu H, Liu Q, Zhang L, Liu B, Sugimoto K, Wu Q: Aquaporin-1, a New Maternally Expressed Gene, Regulates Placental Development in the Mouse. Biology of reproduction 2016, 95(2):40. Guo J, He H, Liu Q, Zhang F, Lv J, Zeng T, Gu N, Wu Q: Identification and Epigenetic Analysis of a Maternally Imprinted Gene Qpct. Mol Cells 2015, 38(10):859-865. Zeng TB, He HJ, Han ZB, Zhang FW, Huang ZJ, Liu Q, Cui W, Wu Q: DNA methylation dynamics of a maternally methylated DMR in the mouse Dlk1-Dio3 domain. FEBS letters 2014, 588(24):4665-4671. He HJ, Hou L, Wang JX, Zhao XF: The apoptosis inhibitor survivin prevents insect midgut from cell death during postembryonic development. Mol Biol Rep 2012, 39(2):1691-1699. He HJ, Wang Q, Zheng WW, Wang JX, Song QS, Zhao XF: Function of nuclear transport factor 2 and Ran in the 20E signal transduction pathway in the cotton bollworm, Helicoverpa armigera. BMC Cell Biol 2010, 11:1. Dong DJ*, He HJ*, Chai LQ*, Jiang XJ, Wang JX, Zhao XF: Identification of genes differentially expressed during larval molting and metamorphosis of Helicoverpa armigera. BMC Dev Biol 2007, 7:73.(并列第一) Cai J, Yang L, He HJ, Xu T, Liu HB, Wu Q, Ma Y, Liu QH, Nie MH: Antioxidant capacity responsible for a hypocholesterolemia is independent of dietary cholesterol in adult rats fed rice protein. Gene 2014, 533(1):57-664. Huang Z, Han Z, Zhang F, He H, Yu S, Wu Q: Spatiotemporal expression of retrogene-host pair Mcts2/H13 in mouse embryo, and Mcts2 has no influence on H13 transcription pattern in NIH/3T3 cells. Acta Histochem 2014, 116(2):312-318. Liu H, Zhu R, Lv J, He H, Yang L, Huang Z, Su J, Zhang Y, Yu S, Wu Q: DevMouse, the mouse developmental methylome database and analysis tools. Database (Oxford) 2014, 2014:bat084. Liu Q, He H, Zeng T, Huang Z, Fan T, Wu Q: Neural-specific expression of miR-344-3p during mouse embryonic development. J Mol Histol 2013. Lv J*, Cui W*, Liu H*, He H, Xiu Y, Guo J, Liu Q, Zeng T, Chen Y, Zhang Y et al: Identification and Characterization of Long Non-Coding RNAs Related to Mouse Embryonic Brain Development from Available Transcriptomic Data. PLoS One 2013, 8(8):e71152. Qi L, Hongjuan H, Ning G, Zhengbin H, Yanjiang X, Tiebo Z, Zhijun H, Qiong W: miR-370 is stage-specifically expressed during mouse embryonic development and regulates Dnmt3a. FEBS Lett. 2013 Mar 18;587(6):775-81 Zeng TB, He HJ, Zhang FW, Han ZB, Huang ZJ, Liu Q, Wu Q: Expression analysis of AK003491, an imprinted noncoding RNA, during mouse development. Genes Genet Syst 2013, 88(2):127-133. Yang L, Han G, Liu QH, Wu Q, He HJ, Cheng CZ, Duan YJ: Rice protein exerts a hypocholesterolemic effect through regulating cholesterol metabolism-related gene expression and enzyme activity in adult rats fed a cholesterol-enriched diet. Int J Food Sci Nutr 2013, 64(7):836-842. Cai MJ, Liu W, He HJ, Wang JX, Zhao XF: Mod(mdg4) participates in hormonally regulated midgut programmed cell death during metamorphosis. Apoptosis 2012, 17(12):1327-1339. Gu T, He H, Han Z, Zeng T, Huang Z, Liu Q, Gu N, Chen Y, Sugimoto K, Jiang H et al: Expression of macro non-coding RNAs Meg8 and Irm in mouse embryonic development. Acta Histochem 2012, 114(4):392-399. Gu T, He H, Zhang Y, Han Z, Hou G, Zeng T, Liu Q, Wu Q: Trmt112 gene expression in mouse embryonic development. Acta Histochem Cytochem 2012, 45(2):113-119. Han Z, He H, Zhang F, Huang Z, Liu Z, Jiang H, Wu Q: Spatiotemporal expression pattern of Mirg, an imprinted non-coding gene, during mouse embryogenesis. J Mol Histol 2012, 43(1):1-8. Yanjiang X, Hongjuan H, Tiantian G, Yan Z, Zhijun H, Qiong W: Expression patterns of ubiquitin conjugating enzyme UbcM2 during mouse embryonic development. Gene Expr 2012, 15(4):163-170. Zhang FW, Han ZB, Deng CY, He HJ, Wu Q: Conservation of genomic imprinting at the NDN, MAGEL2 and MEST loci in pigs. Genes Genet Syst 2012, 87(1):53-58. Gu T, He H, Xing Y, Liu Q, Gu N, Kenkichi S, Jiang H, Wu Q: Expression of non-coding RNA AB063319 derived from Rian gene during mouse development. J Mol Histol 2011, 42(2):105-112. Yan C, Hongjuan H, Yanjiang X, Zhengbin H, Kai L, Fengwei Z, Jing H, Qiong W: Expression patterns of imprinted gene Inpp5f-v3 during mouse brain development. J Mol Histol 2011, 42(2):167-173. Xu Q, Zhang F, He H, Xu S, Li K, Liu S, Li Y, Wu Q: Expression profile of mouse Mterfd2, a novel component of the mitochondrial transcription termination factor (MTERF) family. Genes Genet Syst 2011, 86(4):269-275. Zhang FW, Deng CY, He HJ, Gu N, Han ZB, Chen Y, Wu Q: Molecular cloning, mRNA expression and imprinting status of PEG3, NAP1L5 and PPP1R9A genes in pig. Genes Genet Syst 2011, 86(1):47-52. Zhang FW, Zeng TB, Han ZB, He HJ, Chen Y, Gu N, Jiang HJ, Wu Q: Imprinting and expression analysis of a non-coding RNA gene in the mouse Dlk1-Dio3 domain. J Mol Histol 2011, 42(4):333-339. Wang LF, Chai LQ, He HJ, Wang Q, Wang JX, Zhao XF: A cathepsin L-like proteinase is involved in moulting and metamorphosis in Helicoverpa armigera. Insect Mol Biol 2010, 19(1):99-111. Wang Q, Liu Y, He HJ, Zhao XF, Wang JX: Immune responses of Helicoverpa armigera to different kinds of pathogens. BMC Immunol 2010, 11:9. Zhao XF, He HJ, Dong DJ, Wang JX: Identification of differentially expressed proteins during larval molting of Helicoverpa armigera. J Proteome Res 2006, 5(1):164-169.

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