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Deficiency of WTAP in hepatocytes induces lipoatrophy and non-alcoholic steatohepatitis (NASH). Li X#, Ding K#, Li X, Yuan B, Wang Y, Yao Z, Wang S, Huang H, Xu B, Xie L, Deng T, Chen X-W, Chen Z*. 2022 期刊名称 Nature Communications 期卷 13(1):4549.
The methyltransferase METTL3 negatively regulates nonalcoholic steatohepatitis (NASH) progression. Li X#, Yuan B#, Lu M, Wang Y, Ding N, Liu C, Gao M, Yao Z, Zhang S, Zhao Y, Xie L, Chen Z*. 2021 期刊名称 Nature Communications 期卷 12(1):7213
METTL3 is essential for postnatal development of brown adipose tissue and energy expenditure in mice Wang Y, Gao M, Zhu F, Li X, Yang Y, Yan Q, Jia L, Xie L, Chen Z*. 2020 期刊名称 Nature Communications 期卷 11(1):1648. doi: 10.1038/s41467-020-15488-2.
A long non-coding RNA, APOA4-AS, regulates APOA4 expression depending on HuR in mice Qin W, Li X, Xie L, Li S, Liu J, Jia L, Dong X, Ren X, Xiao J, Yang C, Zhou Y, and Chen Z* 2016 期刊名称 Nucleic Acids Research 期卷 44(13):6423-33
Downregulation of the m6A reader protein YTHDC1 leads to islet β-cell failure and diabetes. Li X, Yang Y, Chen Z* 2023 期刊名称 Metabolism 期卷 138,155339
Li X, Jiang Y, Sun X, Wu Y, Chen Z*. 2021.01 期刊名称 Metabolism 期卷 116, 154702
论文标题
Deficiency of WTAP in islet beta cells results in beta cell failure and diabetes in mice. Li X, Yang Y, Li Z，Wang Y，Qiao J，Chen Z*. 2023 期刊名称 Diabetologia 期卷 doi: 10.1007/s00125-023-05900-z. PMID: 36920524
WTAP Regulates Postnatal Development of Brown Adipose Tissue by stabilizing METTL3 in mice. Wang Y,Li X, Liu C, Zhou L, Shi L, Zhang Z, Chen L, Gao M, Gao L, Xu Y, Huang H, Li J, Chen Z*. 2022 期刊名称 Life Metabolism 期卷 doi.org/10.1093/lifemeta/loac028
Activation of NF-κB-inducing kinase in islet β cells causes β-cell failure and diabetes Li X, Wu Y, Song Y, Ding N, Lu M, Jia L, Zhao Y, Liu M, Chen Z* 2020 期刊名称 Molecular Therapy 期卷 doi.org/10.1016/j.ymthe.2020.07.016
Progress and prospects of long noncoding RNAs in lipid homeostasis Chen Z* 2016 期刊名称 Molecular Metabolism 期卷 5(3), 164-170
Purb promotes hepatic glucose production by increasing Adcy6 transcription Jia L, Jiang Y, Li X, Chen Z*. 2020 期刊名称 Molecular Metabolism 期卷 31 (2020) 85-97
Downregulation of hepatic METTL3 contributes to APAP-induced liver injury in mice Liu C, Li X, Gao M, Dong Y, Chen Z* 2023-04 期刊名称 JHEP Reports 期卷 doi.org/10.1016/j.jhepr.2023.100766
GBP5 promotes liver injury and inflammation by inducing hepatocyte apoptosis Ding K, Li X, Ren X, Ding N, Tao L, Dong X, Chen Z*. 2022 期刊名称 FASEB Journal 期卷 36:e22119
Discovery of a potent and selective NF-κB-inducing kinase (NIK) inhibitor that has anti-inflammatory effects in vitro and in vivo Li Z#, Li X#, Su MB#, Gao LX, Zhou YB, Yuan B, Lyu X, Yan Z, Hu C, Zhang H, Luo C, Chen Z*, Li J*, Zhao Y*. 2020 期刊名称 J Med Chem. 期卷 PMID: 32216342 DOI: 10.1021/acs.jmedchem.0c00396
Islet α-cell Inflammation Induced By NF-κB inducing kinase (NIK) Leads to Hypoglycemia, Pancreatitis, Growth Retardation, and Postnatal Death in Mice Li X, Jia L, Chen X, Dong Y, Ren X, Dong Y, Chen Y, Xie L, Liu M, Shiota C, Gittes GK, Rui L, Chen Z*. 2018 期刊名称 Theranostics 期卷 8(21):5960-5971.
Ren X, Li X, Jia L, Chen D, Hou H, Rui L, Zhao Y,Chen Z*.A small-molecular inhibitor ofNFkB-inducing kinase (NIK) protects liver from toxin-induced inflammation, oxidativestress,and injury.FASEB Journal.2017 31 (2):711-718
Tao L, Jia L, Li Y, Song C,Chen Z*.Recent advances of adapter proteins in the regulationofheart diseases.Heart Fail Rev.2017 22(1):99-107
Chen Z*. Adapter proteins regulate insulin resistance and lipid metabolism in obesity.Science Bulletin. 201661: 1489-1497
Qin W, Li X, Xie L, Li S, Liu J, Jia L, Dong X, Ren X, Xiao J, Yang C, Zhou Y, andChenZ*.Along non-coding RNA, APOA4-AS, regulates APOA4 expression depending on HuR inmice.NucleicAcids Research.2016 44
6423-33. Chen Z*.Progress and prospects of long noncoding RNAs in lipid homeostasis. Molecular Metabolism. 20165(3), 164-170.
Ramakrishnan SK, Zhang H, Takahashi S, Centofanti B, Periyasamy S, Weisz K,Chen Z,Uhler MD, Rui L, Gonzalez FJ, Shah YM.HIF2α Is an Essential Molecular Brake for Postprandial Hepatic Glucagon Response Independent of Insulin Signaling.Cell Metab.2016 Mar 8;23(3):505-16.
Chen Z., Canet, M. J., Sheng, L., Jiang, L., Xiong, Y., Yin, L., and Rui, L. Hepatocyte TRAF3 promotes insulin resistance and type 2 diabetes in mice with obesity.Molecular Metabolism.2015 4, 951-960
Jiang B, Shen H,Chen Z, Yin L, Zan L, Rui L.Carboxyl terminus of HSC70-interacting protein (CHIP) downregulates NF-κB-inducing kinase (NIK) and suppresses NIK-induced liver injury.J Biol Chem.2015 May 1;290(18):11704-14.
Chen Z, Shen H, Sun C, Yin L, Tang F, Zheng P, Liu Y, Brink R, Rui L.Myeloid Cell TRAF3 Promotes Metabolic Inflammation, Insulin Resistance, and Hepatic Steatosis in Obesity.Am J Physiol Endocrinol Metab.2015 Mar 15;308(6):E460-9.
Sun J, Cui J, He Q,Chen Z, Arvan P, Liu M.Proinsulin misfolding and endoplasmic reticulum stress during the development and progression of diabetes.Mol Aspects Med. 2015 Jan 8. pii: S0098-2997(15)00002-3.
Shen H, Sheng L,Chen Z, Jiang L, Su H, Yin L, Omary MB, Rui L.Mouse hepatocyte overexpression of NF-κB-inducing kinase (NIK) triggers fatal macrophage-dependent liver injury and fibrosis.Hepatology.2014 Dec;60 (6):2065-76.
Yuan Q*,Chen Z* (co-first author), Santulli G, Gu L, Yang ZG, Yuan ZQ, Zhao YT, Xin HB, Deng KY, Wang SQ, Ji G. Functional role of calstabin 2 in age-related cardiac alterations.Sci Rep.2014 Dec 11;4:7425.
Chen Z, Morris DL, Lin J, Liu Y, Rui L.SH2B1 in β cells regulates glucosemetabolism by promoting β cell survival and islet expansion.Diabetes.2014, 63 (2), 585-595
Chen Z, Morris DL, Lin J, Liu Y, Rui L. SH2B1 in β cells promotes insulin expression and glucose metabolism in mice.Molecular Endocrinology.2014, 28 (5), 696-705
Sheng L, Liu Y, Jiang L,Chen Z, Zhou Y, Cho KW, Rui L. Hepatic SH2B1 and SH2B2 regulate liver lipid metabolism and VLDL secretion in mice.PloS One. 2013, 8(12):e83269.
Chen Zheng.Nuclear Medicine Contributes to the Identification of Brown Adipose Tissue in Adult Human.J Nucl Med Radiat Ther.2012, 3:5 (Editorial Article)
Sheng L, Zhou Y,Chen Z, Ren D, Cho KW, Jiang L, Shen H, Sasaki Y, Rui L.,NF-kB-inducing Kinase (NIK) Promotes Hyperglycemia and Glucose Intolerance in Obesity by Augmenting Glucagon Action.Nature medicine.2012, 18: 943-949
Shen H, Shao M, Cho KW, Wang S,Chen Z, Sheng L, Wang T, Liu Y, Rui L. Herbal Constituent Sequoyitol Improves Hyperglycemia and Glucose Intolerance by Targeting Hepatocytes, Adipocytes, andβcells.Am J Physiol Endocrinol Metab.2012, 302 (8): E932-40.
Chen Z, Sheng L, Shen H, Zhao Y, Wang S, Brink R, Rui L. Hepatic TRAF2 regulates glucose metabolism through enhancing glucagon responses.Diabetes.2012, 61:566-573.
Pan C, Zhou R,Chen Z, Chen Y, Wu Y, Miao L, Yin W, Ji G.ERp44 Mediates Gene Transcription via Inositol 1, 4, 5-trisphosphate Receptors in Hela Cells.Progress in Biochemistry and Biophysics.2011, 38(8): 706~712.
Tong X,Muchnik M,Chen Z,Patel M,Wu N,Joshi S,Rui L,Lazar MA,Yin L. Transcriptional Repressor E4 Binding Protein 4 (E4BP4) Regulates Metabolic Hormone Fibroblast Growth Factor 21 (FGF21) during Circadian Cycles and Feeding.J Biol Chem.2010285(47):36401-9
Wang X,Xie W,Zhang Y,Lin P,Han L,Han P,Wang Y,Chen Z,Ji G,Zheng M,Weisleder N,Xiao RP,Takeshima H,Ma J,Cheng H.Cardioprotection of Ischemia/Reperfusion Injury by Cholesterol-Dependent MG53-Mediated Membrane Repair.Circ Res.2010 107(1):76-83.
Chen Z, Li Z, Wei B, Yin W, Xu T, Kotlikoff MI, Ji G.FKBP12.6-knockout mice display hyperinsulinemia and resistance to high-fat diet-induced hyperglycemia.FASEB J.2010 24: 357-363.
Zhang X*, Tallini YN*,Chen Z*(co-first author), Gan L, Wei B, Doran R, Miao L, Xin HB, Kotlikoff MI, Ji G.Dissociation of FKBP12.6 from ryanodine receptor type 2 is regulated by cyclic ADP-ribose but not beta-adrenergic stimulation in mouse cardiomyocytes.Cardiovasc Res. 2009 Nov 1;84(2):253-62.
Chen Z, Li Z, Peng G, Chen X, Yin W, Kotlikoff MI, Yuan ZQ, Ji G.Extracellular ATP-induced nuclear Ca2+ transient is mediated by inositol 1,4,5-trisphosphate receptors in mouse pancreatic beta-cells.Biochem Biophys Res Commun. 2009 May 1;382(2):381-4.
Wei B*,Chen Z*(co-first author), Zhang X, Feldman M, Dong XZ, Doran R, Zhao BL, Yin WX, Kotlikoff MI, Ji G.Nitric oxide mediates stretch-induced Ca2+ release via activation of phosphatidylinositol 3-kinase-Akt pathway in smooth muscle.PLoS One. 2008 Jun 25;3(6):e2526.
Zhang LQ*, Zhang HJ*, Guo P, Xue P, Xie ZS,Chen Z, Jing GZ.C-terminal effect of Thermoanaerobacter tengcongensis ribosome recycling factor on its activity and conformation changes.Arch Biochem Biophys. 2007 Oct 15;466(2):211-20.
Wang M,Chen Z, Xing Y, Zhang X, Dong XZ, Ji GJ.Localized Ca2+ uncaging induces Ca2+ release through IP3R in smooth muscle.Acta Pharmacol Sin. 2006 Jul;27(7):939-44.
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