高亮 - 中国科学院大学 - 生命科学学院

个人简介

招生专业 071006-神经生物学招生方向神经免疫学教育背景 2009-10--2014-12 德国海德堡大学博士 2006-09--2009-06 第二军医大学硕士 2000-09--2004-06 天津科技大学学士工作简历 2015-01~2017-09,德国癌症研究中心, 博士后教授课程神经生物学基础科研项目（ 1 ）阿尔茨海默症的诊治方法研究, 参与, 省级, 2018-12--2022-12 （ 2 ） 2019优青基金新引进启动项目, 主持, 市地级, 2020-01--2021-12 （ 3 ）深港脑科学创新研究院开放课题, 主持, 省级, 2019-01--2023-12 参与会议（1）Neutrophil slow rolling involves CD95 activation of integrin signaling 2015-11-08

研究领域

We are interested in the molecular and cellular functions of peripheral immune system in CNS injury and degenerative diseases, specially focus on infiltrating monocyte in mediating the immune response post ischemic stroke and inflammaging in the induction of AD. As immune response is a double-edged sword in neuronal death and regeneration post injury, understanding and fine tuning the balance between proinflammatory and anti-inflammatory responses provides new strategies for the relief of neural injury and promotion of regeneration. Aging is the key risking factor for neuronal degenerative diseases, accumulated distortions in the aged immune system lead to the interruption of immune niche in CNS and finally disturb the immune-protective effect of glial cells on neuronal survival. Thus, it is of great importance to find out the mechanism of inflammaging in the induction and progression of CNS degeneration. Additionally, we will also investigate the role of neural circuitry regulations on immune system in homeostasis and immune disease progression. The innervation of sympathetic and parasympathetic nerves in immune organs provide controlling hubs for CSN in regulating immune activities. However, the detailed neural circuitry and molecular mechanisms of how CNS directing immune system still remains mysteries.

近期论文

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（1） An Immune-CNS Axis Activates Remote Hippocampal Stem Cells Following Spinal Transection Injury, Frontiers in Molecular Neuroscience, 2018, 第 3 作者（2） Endothelial cell-derived CD95 ligand serves as a chemokine in induction of neutrophil slow rolling and adhesion, eLife, 2016, 第 1 作者（3） Infiltration of circulating myeloid cells through CD95L contributes to neurodegeneration in mice, The Journal of Experimental Medicine, 2015, 第 1 作者（4） Blocking P2X receptors can inhibit the injury-induced proliferation of olfactory epithelium progenitor cells in adult mouse, International Journal of Pediatric Otorhinolaryngology, 2010, 第 1 作者