个人简介
招生专业
071010-生物化学与分子生物学
招生方向
分子伴侣协助下蛋白质折叠与解聚的结构生物学
结构生物学
教育背景
1995-09--2000-07 吉林大学 博士
1991-09--1995-07 辽宁师范大学 学士
工作简历
2011-07~现在, 中国科学院上海生命科学研究院生物化学与细胞生物学研究所, 研究员
2010-10~2011-06,美国贝勒医学院国家大分子影像中心, 讲师
2005-06~2010-09,美国贝勒医学院国家大分子影像中心, 助理研究员
2003-05~2005-05,美国德州大学休斯顿健康科学中心, 博士后
2001-11~2003-04,美国Scripps研究所, 博士后
奖励信息
（1） 上海市生物物理学科优秀女青年科技工作者, 市地级, 2015
（2） 国家基金委优秀青年, 国家级, 2012
（3） 中科院“****”, 研究所（学校）, 2012
科研项目
（ 1 ） 基于超低温冷冻电镜的蛋白酶体结构与功能研究, 主持, 国家级, 2013-01--2016-12
（ 2 ） 近原子分辨成像和三维重构技术, 主持, 部委级, 2014-01--2018-12
（ 3 ） 应用国家蛋白质科学研究(上海)设 施分子影像技术探索染色质的组装与重塑, 主持, 省级, 2013-07--2016-08
（ 4 ） 蛋白质复合物调控染色体结构的分子机理, 主持, 国家级, 2013-01--2017-08
（ 5 ） 基于冷冻电镜的真核细胞分子伴侣素TRiC的结构与功能研究, 主持, 国家级, 2017-01--2020-12
（ 6 ） 开发基于病毒样颗粒的新型疫苗关键技术平台, 主持, 部委级, 2015-01--2016-12
（ 7 ） 脂代谢相关蛋白的免疫调控功能研究, 参与, 部委级, 2017-01--2021-12
（ 8 ） 细胞运动关键辅助蛋白复合物的结构、组装与功能, 参与, 国家级, 2017-07--2022-06
（ 9 ） 电镜系统的Titan Krios冷冻电镜升级改造, 主持, 部委级, 2018-01--2020-12
（ 10 ） 行动中的蛋白酶体：从底物识别、处理到水解的机制研究, 主持, 国家级, 2019-01--2021-12
（ 11 ） 基于冷冻电镜的组蛋白H3K4甲基转移酶COMPASS复合体的结构与功能研究, 主持, 国家级, 2019-01--2022-12
（ 12 ） 冷冻电镜原位结构动态分析技术, 主持, 部委级, 2020-01--2024-12
参与会议
（1） Proteasome in Action Revealed by Near-atomic Resolution Cryo-EM 2019-12-16
（2）An ensemble of cryo-EM structures of TRiC reveal its conformational landscape and subunit specificity 2019-10-16
（3）An ensemble of cryo-EM structures of TRiC reveals its conformational landscape and subunit specificity 2019-09-14
（4）Atomic-resolution Cryo-EM Structure Based Vaccine and Drug Discovery against Enterovirus 2019-03-21
（5）Protein Quality Control Nanomachine in Action Revealed by Near-atomic Resolution Cryo-EM 2018-10-23
（6）ATP Triggered Opposite Modes of Action of the ATPase in Protein 2018-05-03
（7）“Ensemble of cryo-EM structures of eukaryotic chaperonin TRiC/CCT reveals its stepwise ring closure mechanism” 2018-04-17
（8）ATP Triggered Opposite Modes of Action of the ATPases in Protein Quality Control Revealed by Cryo-EM 2018-04-06
（9）ATP Triggered Opposite Modes of Action of the ATPases in Protein Quality Control Revealed by Cryo-EM 2017-06-09
（10）ATP Triggered Opposite Modes of Action of the ATPases in Protein Quality Control Revealed by Cryo-EM 2017-05-17
（11）18) Stepwise nucleotide-binding mechanism of eukaryotic chaperonin TRiC/CCT revealed by high-resolution cryo-EM 2017-05-17
（12）Stepwise nucleotide-binding mechanism of eukaryotic chaperonin TRiC/CCT revealed by high-resolution cryo-EM 2016-06-24
（13）Cryo-EM visualization of antibody-virus complex 2016-01-12
（14）Structural basis for recognition of human enterovirus 71 by a broadly neutralizing monoclonal antibody revealed by cryo-EM 2015-06-03
（15）Structural basis for recognition of human enterovirus 71 by a broadly neutralizing monoclonal antibody revealed by cryo-EM 2015-05-09
（16）Structural basis for recognition of human enterovirus 71 by a broadly neutralizing monoclonal antibody revealed by cryo-EM 2015-05-07
（17）Structural basis for recognition of human enterovirus 71 by a broadly neutralizing monoclonal antibody revealed by cryo-EM 2015-04-23
（18）Cryo-EM of asymmetric and dynamic protein folding nanomachineTRiC 2014-07-26
（19）Proteins in disease I 2014-05-17
（20）Cryo-EM Study on Asymmetric and Dynamic Protein Folding NanomachineTRiC 2014-05-12
（21）Cryo-EM Study on Asymmetric and Dynamic Macromolecular Machine TRiC 2013-12-07
（22）Cryo-EM Study on Asymmetric and Dynamic Macromolecular Machine TRiC 2013-10-15
（23）2D Image Alignment and Classification 2013-07-10
（24）Symmetry-Free Cryo-EM Structures of the Chaperonin TRiC Along its ATPase-Driven Conformational Cycle 2012-09-07
（25）Symmetry-Free Cryo-EM Structures of the Chaperonin TRiC Along its ATPase-Driven Conformational Cycle 2012-01-05
（26）Structural Characterization of the Eukaryotic Chaperonin TRiC/CCT by cryo-EM, NCMI Workshop on Single Particle Reconstruction 2011-03-14
近期论文
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1.Yin W, Li Z, Jin M, Yin YL, Waal PW, Pal K, Yin Y, Gao X, He Y, Gao J, Wang X, Zhang Y, Zhou H, Melcher K, Jiang Y, Cong Y*, Zhou XE*, Yu X*, Xu HE*. (2019) A complex structure of arrestin-2 bound to a G protein-coupled receptor. Cell Research, 29:971–983.
2.Jin M, Han W, Liu C, Zang Y, Li J, Wang F, Wang Y, Cong Y*. (2019) An ensemble of cryo-EM structures of TRiC reveals its conformational landscape and subunit specificity. Proc Natl Acad Sci, 116(39):19513–19522.
3.Ding Z, Xu C, Sahu I, Wang Y, Fu Z, Huang M, Wong CCL, Glickman MH, and Cong Y*. (2019) Structural Snapshots of 26S Proteasome Reveal Tetraubiquitin-Induced Conformations. Molecular Cell, 73:1150-1161.
4.Chen J, Ye X, Zhang X, Zhu Z, Zhang X, Xu Z, Ding Z, Zou G, Liu Q, Kong L, Jiang W, Zhu W, Cong Y*and Huang Z*. (2019) Coxsackievirus A10 atomic structure facilitating the discovery of a broadspectrum inhibitor against human enteroviruses. Cell Discovery, 5:4.
5.Wang Y, Ding Z, Liu X, Bao Y, Huang M, Wong CCL, Hong X, Cong Y*. (2018) Architecture and subunit arrangement of the complete Saccharomyces cerevisiae COMPASS complex. Scientific Reports, 8:17405.
6.Wang H, Han W, Takagi J*, Cong Y*. (2018) Yeast inner-subunit PA–NZ-1 labeling strategy for accurate subunit identification in a macromolecular complex through cryo-EM analysis. Journal of Molecular Biology,430(10):1417-1425.
7.Zang Y, Wang H, Cui Z, Jin M, Liu C, Han W, Wang YX, Cong Y*. (2018) Development of a yeast internal-subunit eGFP labeling strategy and its application in subunit identification in eukaryotic group II chaperonin TRiC/CCT. Scientific Reports, 8(1):2374.
8.Chen J, Zhang C, Zhou Y, Zhang X, Shen C, Ye X, Jiang W, Huang Z* and Cong Y*. (2018) A 3.0-Angstrom Resolution Cryo-Electron Microscopy Structure and Antigenic Sites of Coxsackievirus A6-Like Particles. Journal of Virology, 92: e01257-17.
9.Wang X, Ku Z, Zhang X, Ye X, Chen J, Liu Q, Zhang W, Zhang C, Fu Z, Jin X, Cong Y* and Huang Z*. (2018) Structure, Immunogenicity and Protective Mechanism of an Engineered Enterovirus 71-Like Particle Vaccine Mimicking 80S Empty Capsid. Journal of Virology, 92:e01330-17.
10.Jin M, Cong Y. (2017) Identification of an allosteric network that influences assembly and function of group II chaperonins. Nat Struct Mol Biol, 24:683–684.
11.Fan C, Ye X, Ku Z, Kong L, Liu Q, Xu C, Cong Y*, Huang Z*. (2017) Beta-propiolactone inactivation of coxsackievirus A16 induces structural alteration and surface modification of viral capsids.Journal of Virology, 91:e00038-17.
12.Ding Z, Fu Z, Xu C, Wang YF, Wang YX, Li J, Kong L, Chen J, Li N, Zhang R, Cong Y*. (2017) High-resolution cryo-EM structure of the proteasome in complex with ADP-AlFx. Cell Research, 27:373–385.
13.Zang Y, Jin M, Wang H, Cui Z, Liu C, Kong L, Cong Y*. (2016) Staggered ATP-binding mechanism of eukaryotic chaperonin TRiC/CCT revealed by high-resolution cryo-EM. Nat Struct Mol Biol, 23(12):1083-1091.
14.Shao J, Fu Z, Ji Y, Guan X, Guo S, Ding Z, Yang X*, Cong Y*, Shen Y*. (2016) Leucine zipper-EF-hand containing transmembrane protein 1 (LETM1) forms a Ca2+/H+ antiporter. Scientific Reports, 6:34174.
15.Ye X, Fan C, Ku Z, Zuo T, Kong L, Zhang C, Shi J, Liu Q, Chen T, Zhang Y, Jiang W, Zhang L, Huang Z*, Cong Y*. (2016) Structural Basis for Recognition of Human Enterovirus 71 by a Bivalent Broadly Neutralizing Monoclonal Antibody. PLoS Pathogens, 12(3):e1005454.
16.Oxenoid K, Dong Y, Cao C, Cui T, Sancak Y, Markhard AL, Grabarek Z, Kong L, Liu Z, Ouyang B, Cong Y, Mootha VK, Chou JJ*. (2016) Architecture of the mitochondrial calcium uniporter. Nature, 533(7602):269-273.
17.Jin W, Wang Y, Liu CP, Yang N, Jin M, Cong Y, Wang M*, Xu RM*. (2016) Structural basis for snRNA recognition by the double-WD40 repeat domain of Gemin5. Genes & Dev, 30(21):2391-2403.
18.Cheng H, Fan C, Zhang S, Wu Z, Cui Z, Melcher K, Zhang C, Jiang Y, Cong Y, Xu HE*. (2015) Crystallization scale purification of a7 nicotinic acetylcholine receptor from mammalian cells using a BacMam expression system. Acta Pharmacol Sin, 36(8):1013-1023.
19.Wu Z, Cui Z, Cheng H, Fan C, Melcher K, Jiang Y, Zhang C, Jiang H, Cong Y, Liu Q*, Xu HE*. (2015) High yield and efficient expression and purification of the human 5-HT3A receptor. Acta Pharmacol Sin, 36(8):1024-1032.
20.Guo X, Wang L, Li J, Ding Z, Xiao J, Yin X, He S, Shi P, Dong L, Li G, Tian C, Wang J, Cong Y, Xu Y*. (2015) Structural Insight into Autoinhibition and Histone H3-induced Activation of DNMT3A. Nature, 517(7536):640-644.
21.Ye X, Ku Z, Liu Q, Wang X, Shi J, Zhang Y, Kong L, Cong Y, Huang Z*. (2014) Chimeric virus-like particle vaccines displaying conservedenterovirus 71epitopes elicit protective neutralizing antibodies in mice through divergentmechanisms. Journal of Virology, 88(1):72-81.
22.Shahmoradian SH, Galaz-Montoya JG, Schmid MF, Cong Y, Ma B, Spiess C, Frydman J, Ludtke SJ, Chiu W*. (2013) TRiC’s tricks inhibit huntingtin aggregation. eLife, 2:e00710.
23.Zhang Q, Dai X, Cong Y, Zhang J, Chen DH, Dougherty MT, Wang J, Ludtke SJ, Schmid MF, Chiu W*. (2013) Cryo-EM Structure of a Molluscan Hemocyanin Suggests Its Allosteric Mechanism. Structure, 21(4):604-613.
24.Feng M, Ding Z, Xu L, Kong L, Wang W, Jiao S, Shi Z, Greene MI, Cong Y*, Zhou Z*. (2013) Structural and biochemical studies of RIG-I antiviral signaling. Protein Cell, 4(2):142-154.
25.Leitner A, Joachimiak LA, Bracher A, Mönkemeyer L, Walzthoeni T, Chen B, Pechmann S, Holmes S, Cong Y, Ma B, Ludtke S, Chiu W, Hartl FU, Aebersold R*, Frydman J*. (2012) The Molecular Architecture of the Eukaryotic Chaperonin TRiC/CCT. Structure, 20(5):814-825.
26.Cong Y, Schröder GF, Meyer AS, Jakana J, Ma B, Dougherty MT, Schmid MF, Reissmann S, Levitt M, Ludtke SL, Frydman J, Chiu W*. (2012) Symmetry-free cryo-EM structures of the chaperonin TRiC along its ATPase-driven conformational cycle. EMBO Journal, 31(3):720-730.
27.Zhang R, Hryc CF, Cong Y, Liu X, Jakana J, Gorchakov R, Baker ML, Weaver SC, Chiu W*. (2011) 4.4 Å cryo-EM structure of an enveloped alphavirus Venezuelan equine encephalitis virus. EMBO Journal, 30(18):3854-3863.
28.Cong Y, Ludtke SL. (2010) Single Particle Analysis at High Resolution. Methods in Enzymology, 482:211-235.
29.Cong Y, Baker ML, Jakana J, Woolford D, Miller EJ, Reissmann S, Kumar RN, Redding-Johanson AM, Batth TS, Mukhopadhyay A, Ludtke SJ, Frydman J, Chiu W*. (2010) 4.0 Å Resolution Cryo-EM Structure of the Mammalian Chaperonin TRiC/CCT Reveals its Unique Subunit Arrangement. Proc Natl Acad Sci, 107(11):4967-4972.
30.Cong Y, Zhang Q, Woolford D, Schweikardt T, Khant H, Dougherty M, Ludtke SJ, Chiu W*, Decker H*. (2009) Structural Mechanism of SDS-induced Enzyme Activity of Scorpion Hemocyanin Revealed by Electron Cryo-Microscopy. Structure, 17(5):749-758.
31.Booth CR, Meyer AS, Cong Y, Topf M, Sali A, Ludtke SJ, Chiu W*, Frydman J*. (2008) Mechanism of lid closure in the eukaryotic chaperonin TRiC/CCT. Nat Struct Mol Biol, 15(7):746-753.
32.Cong Y, Topf M, Sali A, Matsudaira P, Dougherty M, Chiu W, Schmid MF*. (2008) Crystallographic conformers of actin in a biologically active bundle of filaments. J Mol Biol, 375(2):331-336.
33.Serysheva II, Ludtke SJ, Baker ML, Cong Y, Topf M, Eramian D, Sali A, Hamilton SL, Chiu W*. (2008) Subnanometer-resolution electron cryomicroscopy-based domain models for the cytoplasmic region of skeletal muscle RyR channel. Proc Natl Acad Sci, 105(28):9610-9615.
34.Cong Y, Jiang W, Birmanns S, Zhou ZH, Chiu W, Wriggers W *. (2005) Fast rotational matching of single-particle images. J Struct Biol, 152(2):104-112.
35.Cong Y, Kovacs JA, Wriggers W. (2003) 2D fast rotational matching for image processing of biophysical data. J Struct Biol, 144(1-2):51-60.
36.Kovacs JA, Chacón P, Cong Y, Metwally E, Wriggers W*. (2003) Fast rotational matching of rigid bodies by fast Fourier transform acceleration of five degrees of freedom. Acta Crystallogr D Biol Crystallogr, 59(8):1371-1376.
37.Yang Z*, Cong Y, Zhao D, Wang C, Bao XH. (2003) Sigma Pi Scheme in Atom-Bond Electronegativity Equalization Method. J Chin Chem Soc-Taipei, 50:785-794.
38.Sun R*, Liu Y, Sun Y, Cong Y, Zhang Z. (2003) Theoretical studies of Si6H3 Si5H6 Si5Li3 and Si5Na3 cluster. J Mol Sci, 19:103-108.
39.Cong Y*, Yang Z, Wang C, Liu X, Bao X. (2002) Investigation of the regio- and stereo-selectivity of Diels-Alder reactions by the newly developed ABEEMσπ model on the basis of local HSAB principle and maximum hardness principle. Chem Phys Lett, 357:59-64.
40.Cong Y, Yang Z. (2000) General atom-bond electronegativity equalization method and its application in prediction of charge distributions in polypeptide. Chem Phys Lett, 316:324-329.
41.Niu S, Jin J, Jin X, Cong Y, Yang Z*. (2000) Crystal structure and magnetism of the binuclear Gd(III) complex Gd2(C12H8N2)2(C6H5COO)6. Chin Sci Bull, 45(8):706-711.
42.Yang Z*, Cong Y, Wang C. (1999) Sigma pi model in the atom-bond electronegativity equalization method and its applications. Chem J Chin Univ, 20:1781-1783.
43.Li S, Wang M, Cong Y, Yang Z*. (1998) Energy transfer of Excited Normal Modes in H2X(X=OS). Chem J Chin Univ, 19:950-954.
44.Wang C, Sun R, Cong Y, Yang Z. (1997) A Theoretical Study of PdCONaOH Complex as a Sample Model of Promoted Catalysis. J Inorg Chem, 13:301-305.
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